Anavex Life Sciences Corp (AVXL): Compiled Due Diligence 05/10/19 Li...

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Friday, 05/10/2019 2:27:42 PM

Friday, May 10, 2019 2:27:42 PM

Compiled Due Diligence 05/10/19

Link to Annual Report:
https://www.sec.gov/Archives/edgar/data/1314052/000161577418014328/0001615774-18-014328-index.htm
https://www.sec.gov/Archives/edgar/data/1314052/000161577418014328/s114606_10k.htm
Link to Pipeline graphic: https://www.sec.gov/Archives/edgar/data/1314052/000161577418014328/img001_v1.jpg
Mouse PET images: https://www.sec.gov/Archives/edgar/data/1314052/000161577418014328/img002_v1.jpg

PIPELINE

Evolution of the pipeline:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147064606

Results of 4/5/19 shareholder vote:
https://www.sec.gov/Archives/edgar/data/1314052/000161577419005452/s117292_8k.htm

Shareholder rights plan:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145724043

Company website - upcoming and past events:
https://www.anavex.com/investor-material/events/

Company Website - presentations on line:
https://www.anavex.com/investor-material/

Transcript of 12/12/18 Conference call:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145435190

Access to 12/18 Conference call:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145347046

Quick link to SEC filings:
https://fintel.io/filings/us/avxl

Link to SEC filings on EDGAR:
https://www.sec.gov/cgi-bin/browse-edgar?CIK=avxl&owner=exclude&action=getcompany
__________________________________________________________________________________________________________________
SHAREHOLDER'S MEETING NOTES:

Discussion of shareholder's meeting 04/05/19 begins here:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148045215

Thanks to our MB, on the scene reporters...
brichnyc, bourbon, and Jonjones325

From bourbon_on_my_cornflakes:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148047383
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148050828
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148058557

From Jonjones325:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148057082
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148057307

From brichnyc:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148084098
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148086244

__________________________________________________________________________________________________________________
RECENT AND UPCOMING PRESENTATIONS, OTHER POSSIBLE EVENTS:

Anavex's SVP of Operations, Stephan Toutain, to speak at the World BI - 13th Clinical Trials Conference, May 7-8 in Boston, MA.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148405784

May 7-8: World BI - 13th Clinical Trials Conference - Boston, MA
Speaker: Stephan Toutain
https://worldbigroup.com/conference/thirteenth-clinical-trials/speakers

June 3-6 : Bio International Convention - Philadelphia, PA
Anavex currently indicated as attending and participating in 1-on-1 Partnering sessions.
https://mybio.org/exhibitor/member/318490

June 4-7 2019, (from kevli33)
Anavex Scientific Advisor attending 5th World Parkinson Congress in Japan.
https://wpc2019.org/page/precongress3
Notes from the above program:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147983117

Missling will speak at the RARE Drug Development Symposium in Philadelphia PA, June 6-7. (from TTav66)
https://globalgenes.org/event/advocacy-symposium/

June 25 : DIA 2019 Global Annual Meeting - San Diego, CA (updated info from TTav66)
Artificial Intelligence Enhanced Data Analytics for Clinical Trials
Panelists: Mohammad Afshar (CEO of Ariana Pharma), and Federico Goodsaid (Principal of Regulatory Pathfinders)
*note: Indication of Dr. Missling's participation was removed at some point after this event was originally shared
https://dia2019globalannualmeeting.sched.com/event/KfWl/245-artificial-intelligence-enhanced-data-analytics-for-clinical-trials

July 23-25 : 2nd Annual NPP ((Neuropsychiatric Drug Development) conference - Boston, MA
- Dr. Missling will lead a workshop; Reviewing the Potential for Precision Medicine in Neurological Diseases on July 23.
- He will also be featured in a 2 person panel with the Executive Director of Neuroscience Discovery at Merck; Panel Discussion: The Precision Medicine Approach to Neuropsychiatry – For or Against? on July 25.
https://npd-summit.com/

Anavex is returning to the 2nd Annual Neuropsychiatric Drug Development Summit from July 23-25 in Boston.

On July 23, Dr. Missling will lead 1 of 3 pre-conference workshops; Reviewing the Potential for Precision Medicine in Neurological Diseases.

On July 25, he will also be featured in a 2-person panel with Sean Smith, the Executive Director of Neuroscience Discovery at Merck; Panel Discussion: The Precision Medicine Approach to Neuropsychiatry – For or Against?

Download the Full Event Guide at the website below for further details:
https://npd-summit.com/

Original from TTAV66:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147736866

Possible Catalysts
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145908635
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148107153

Roth panel discussion "Rise and Fall of Amyloid" 3/19:
http://wsw.com/webcast/roth33/panel22/?lobby=true&day=2

A closer look at the Roth Capital Partners Conference Alz panel that Dr Missling is part of (Beyond the Rise and Fall of Amyloid) - (from makemydaze)
https://www.meetmax.com/upload/event_51941/ROTH_2019_Healthcare_Marango_Panel.pdf

Anavex Life Sciences at the Cowen 39th Annual Health Care Conference 2019 Wednesday, March 13
http://wsw.com/webcast/cowen52/avxl/. A replay will be available via www.anavex.com and will be accessible for three months following the presentation.

Feb. 11-12 : BIO CEO & Investor Conference
Presentation
https://www.veracast.com/webcasts/bio/ceoinvestor2019/78204240532.cfm?0.22201266802
Slides only
https://www.anavex.com/wp-content/uploads/2019/02/Anavex-BIO-CEO-Feb-2019-1.pdf

Missling interview:

__________________________________________________________________________________________________________________
AUDIO PRESENTATIONS:

Cantor Fitzgerald Presentation from Cantor Fitzgerald Global Healthcare Conference October 3, 2018 2:50 p.m.
http://wsw.com/webcast/cantor7/avxl/

Comment on the above from dia76ca "At Cantor Dr. Missing said that the Rett trial would "clear VERY SOON"(At the 27:30 minute mark). We would do well to remember some of the other things he said.(e.g. Cash on hand for 2 years...21:21 minute mark ; Anavex 3-71 in clinic in 2019...29:34 minute mark ; Parkinson read-out in 2019...30:40 minute mark."
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144349470

Additional audio presentations on the company web site see links at top of post.
___________________________________________________________________________________________________________________
VIDEO PRESENTATIONS

Dr. Harald Hampel, MD, PhD, MA, MSc: Genomic Analysis of ANAVEX 2-73 in Alzheimer Disease Study 10/18, Videos:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148601340

Anavex SAB member Dr Paul Aisen speaks about PET Scans:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143921781

History of rettsyndrome.org featuring Christopher Missling:

Dr. Tangui Maurice on the Sigma 1 - 2015 video:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143980208

Additional video presentations on the company web site see links at top of post.

Videos from UC and Rob Knight (not Anavex specific, but cutting edge science.)
Microbiomes and aging:
https://youtu.be/2iKHMyWzclM
Microbiome mind and brain interaction:
https://www.youtube.com/watch?v=2iKHMyWzclM&t=134s
All of Rob Knight's videos are interesting:
https://www.youtube.com/results?search_query=rob+knight

___________________________________________________________________________________________________________________
SLIDE SHOWS AND POSTERS:

From TTTav: October Corporate Presentation used at the Cantor Fitzgerald Conference
https://www.anavex.com/wp-content/uploads/2018/10/Anavex-Presentation-Oct-2018.pdf

Dr Robert Lisak’s MS poster presented at the 2018 ECTRIMS conference:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144223191&txt2find=ectrims

Anavex 2-73 as a potential treatment for autism spectrum disorders 2016
https://anavex.com/wp-content/uploads/2016-06-06_Poster_AV2-73_Autism_FXS_Conference_June_2016.pdf

Kaufmann presentation 3/27/19
American Society for Experimental Neurotherapeutics - ASENT 2019 Annual Meeting
https://www.anavex.com/wp-content/uploads/2019/03/Anavex-ASENT-March-2019.pdf

https://www.anavex.com/wp-content/uploads/2019/03/Anavex-Presentation-March-2019-1.pdf

Titration could increase the response and efficacy of Anavex 2-73.
A plasma concentration of greater than 4 ng/ml would increase postive responses and efficacy to Anavex 2-73 (from georgejjl)

Slide 10
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147511076

From Slide 27:

Value-Creating Catalysts – Clinical updates from Phase 2 Parkinson’s disease dementia study, Phase
2b/3 Alzheimer’s disease and Phase 2 Rett syndrome studies anticipated in 2019. Clinical data
publications and additional indications to be announced in 2019.

Macfarlane and Hammond Care CEO Stephen Judd on overmedication of elderly patients:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146079150

Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease? (from Investor2014)
https://www.alzforum.org/news/research-news/could-disposing-damaged-mitochondria-treat-alzheimers-disease

Do we have a good chance to win in the "Oskar Fischer Project" ?
https://alzheimersnewstoday.com/2018/11/09/new-challenge-offers-prize-money-better-understanding-alzheimers/

Might Anavex-facilitated Sleep Prevent Alzheimer’s? (from Falconer66a)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147042424

P300 Amplitude Discussion: See IP section and Partners section

See also insomnia patent under IP, sleep section, and more in ERP in partners section.
Links at the end of this post

___________________________________________________________________________________________________________________
PARKINSON'S DEMENTIA DISCUSSIONS :

January 19 AU governement allocated an additional $36.8 million for Parkinson's research.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148593663

Hammond Care to join in Parkinson's Dementia trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148578140

Trial listing Parkinson's on clinicaltrials.gov as of 12/13/18
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145772074

EU Parkinson's trial info:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144654071

Spanish trial info:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144654240

Parkinson's researchers have asked for an extension:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147933240
http://wsw.com/webcast/cowen52/avxl/

Parkinson's endpoints cognition and motion
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145688901
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145689920

Spanish info on Parkinson's trial as of 2/26/19
http://www.gacetamedica.com/especializada/comienza-la-segunda-fase-del-estudio-clinico-para-enfermedad-de-parkinson-con-demencia-asociada-MG1945349
English Translation:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147248343

How the Parkinson's Dementia trial may help expedite Alzheimer's approval:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143580569

More on Parkinson's and sleep (from nidan7500):
https://parkinsonsnewstoday.com/2019/03/13/study-factors-sleep-benefit-parkinsons-disease/

Biostockclub on Parkinson's dosage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144533102

Scientists Are Warning of a Future Parkinson's Pandemic, And We Can't Ignore It (from Amateur17)
https://www.sciencealert.com/research-warns-of-a-pending-parkinson-s-pandemic-and-we-need-to-pay-attention

Parkinson's News Today announces trial with participation of MJF foundation from whippensaw:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144653898

Sleep in Parkinson's disease -
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145233486

From K9uwa aka John: Today in Parkinsons News Today ENROLLING NOW in Spain article.
http://parkinsonsnewstoday.com/2018/11/01/anavex-recruiting-parkinsons-dementia-patients-spain-anavex-2-73-trial/

Testing method to be used:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145428524

Dr. M. Angela Cenci Nilsson resulting study from the 2015 research grant
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148339012
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342120
PROFILE
http://www.academia-net.org/profil/prof-dr-m-angela-cenci-nilsson/1488381

Veronica Francardo
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342376
Francardo May 2018 statement on effect of 2-73 in Parkinson's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=134044839

Anavex PR's from the Lund preclinical research on Parkinson's by Cenci-Nilsson and Francardo.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148343391

___________________________________________________________________________________________________________________
RETT SYNDROME DISCUSSION :

Video of Rett Syndrome Kids (from kevli 33)

Australian Rett Syndrom Trial starts May 9 2019 (from Greenspam3)
https://www.facebook.com/rettaustralia/
https://www.anavex.com/rett-syndrome-association-of-australia-and-anavex-life-sciences-announce-initiation-of-the-phase-2-avatar-clinical-study-in-patients-with-rett-syndrome/

On Missling's plan for Rett Trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148732543

"RettSyndrome.org updated their Clinical Trials information on 4/4/19 with the link below.
This will give the Rett Families a bit more information and encourage trial participation."
(Quoted and provided by Talon38)
https://www.rettsyndrome.org/file/press-releases/Anavex-doses-1st-Patient.pdf

Trial listing Rett Syndrome on clinicaltrials.gov as of 12/07/18
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145772107

Rett Syndrome prospects, trial update, and patent (from georgejjl )
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146683698
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146684425
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146720630

ANAVEX 2-73 Normalizes Hippocampal BDNF Expression
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148132992

For the first time a human disease — Rett Syndrome, the first identified epigenetic disease — has been linked to specific defects in the three-dimensional folding of chromatin. (from georgejjl)
https://www2.lbl.gov/Science-Articles/Archive/LSD-Rett-syndrome.html
see also:
https://www2.lbl.gov/Science-Articles/Archive/assets/images/2004/Dec-20/DLX5-Rett-Syndrome.pdf

Epigenomics and Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147643763

On the ambiguity in earnings call on Rett trials:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146678488
Response from runcoach:
https://investorshub.advfn.com/boards/replies.aspx?msg=146678488

FDA Revising ‘Draft Guidance’ on Developing Treatments for Rare Diseases (from nidan7500)
https://rettsyndromenews.com/2019/01/30/fda-revising-draft-guidance-on-developing-treatments-for-rare-diseases/
Levetiracetam possible for Alzheimer's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147247821

Anavex 2-73 synergism with levetiracetam for treatment of Rett syndrome and epilepsy.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147246715

Rett syndrome testing via auditory event:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146263432

Rettsyndromenews.com on the 2-73 trial
https://rettsyndromenews.com/2019/01/08/phase-2-trial-anavex-2-73-rett-syndrome/

Anavex Life Sciences Announces FDA Approval of IND for Phase 2 Trial of ANAVEX®2-73 in Patients with Rett Syndrome
Study will incorporate genomic precision medicine ANAVEX®2-73-specific biomarkers
https://www.anavex.com/anavex-life-sciences-announces-fda-approval-of-ind-for-phase-2-trial-of-anavex2-73-in-patients-with-rett-syndrome/

Rett Syndrome trial and endpoints announced on Clinicaltrials.gov 11/29/18 (Thanks to poster Abel and Cabel)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145164109

Info on Dr. Kaufmann who will be running the 2-73 Rett Syndrome trial and who is now CMO for Anavex:
http://gcbcenter.kennedykrieger.org/staff.jsp

2016 presentation on Rett Syndrome
https://anavex.com//wp-content/uploads/ANAVEX-2-73-as-a-Potential-Treatment-for-Rett-Syndrome.pdf

2017 presentation on Rett Syndrome

Rett Syndrome in adults:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145216562
http://www.anavex.com/wp-content/uploads/2017/05/Anavex-Angelman-FX-Rett-conference-update-2017-May-2017-final.pdf

Rett Syndrome & Fragile x - they are are related:
From Talon38 (post 173314) "NIH's updated (2 days ago) information on Fragile X. Notice both the similarities and differences (predominantly a male diseases). Fragile X is one of 2-73's pipeline targets as is Infantile Spasms and Angelman's. Not a stretch to believe that Tayo Fadiran has been working CDER and NIH for a combined clinical trial approach to these orphan diseases. With positive Rett Syndrome results, that may come to fruition. The 2-73 "train" is gathering momentum!"
https://ghr.nlm.nih.gov/condition/fragile-x-syndrome

Rett Syndrome Study Design a link Natural History Study Publications from Investor2014:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144701675
https://www.rettsyndrome.org/for-researchers/nhs-research-publications

Discussion of Rett Trial Design why it is structured the way it is:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144356675
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145205166

On the disease phases of Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144701046

Will the trial be moved to Australia?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144362026

On Rett Syndrome and the M4 Receptor from Investor2014:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144347886

Other Rett Syndrome related posts:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144357506
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135703149

Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome
https://www.sciencedirect.com/science/article/pii/S0149763418306900 (from Investor2014)

Talon38 provided this NIH link on Rett Syndrome:
https://ghr.nlm.nih.gov/condition/rett-syndrome

dadofmarcmax on Rett Syndrome and other epileptic diseases:
see CNS ADDITiONAL INDICATIONS below

Paper on Rett Syndrome treatment procedures:
https://pdfs.semanticscholar.org/c2c8/1063888a7aecffd3b1fe74a7b67496b2554f.pdf
___________________________________________________________________________________________________________________
EPILEPSY DISCUSSION:

Question of Epilepsy parnership:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147238816

PennyDouble reminds us, we have an expert on the SAB :
https://www.anavex.com/anavex-life-sciences-appoints-distinguished-researcher-neurology-epilepsy-scientific-advisory-board/

The significance of adding Dr Andrew Cole MD authority on Epilepsy to Anavex SAB:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144358640
___________________________________________________________________________________________________________________
FRAGILE X DISCUSSION:

Fragile X syndrome connected to mitochondrial dysfunction. (from Steady_T)
https://medicalxpress.com/news/2019-02-cell-component-breakdown-treatment-multiple.html

Fragile X is a growing concern (link from cninc):
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00564/full
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144971728

Will fragile x start trials soon?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146687514

Anavex 2-73 and the autism market:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147237001&txt2find=2016

Kaufmann paper on FragileX and Autism:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148178337

___________________________________________________________________________________________________________________
MULTIPLE SCLEROSIS DISCUSSION:

Dr Lisak's preclinical of 2-73 in MS:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147244571

MS - needs more scientific development in order to support a successful 2-73 trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145845309
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145855079

Youtubes on Myelin:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145846058

MS is still on the table per 12/12/18 10K
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146069570

MS and gender bias
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145789105

Anavex - Biogen & MS
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135630393
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143729928
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143732818
https://investorshubAL.advfn.com/boards/read_msg.aspx?message_id=143734046
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144040837
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143735763
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147244426

___________________________________________________________________________________________________________________
SCHIZOPHRENIA DISCUSSION :

Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches.
(link from georgejjl)
https://www.ncbi.nlm.nih.gov/pubmed/28890198
see also:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461562/

___________________________________________________________________________________________________________________
OTHER CNS & ADDITIONAL INDICATIONS:

From dadofmarcmax, the linked site has TONS of info:
"Why does Anavex 2-73 have effects on seemingly different neuro-degenerative disorders? What makes it so special? "
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143816865

Falconer on commonalities of CNS disease:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145055598

Anavex 2-73 and/or 3-71 as a treatment for postpartum depression
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144995494&txt2find=71

A2-73 mixed S1R and Muscarinic modulation - not just S1R. (from Investor2014)
Citation from this paper: https://www.google.co.uk/amp/s/www.researchgate.net/publication/11175896_AF150S_and_AF267B_-_M1_muscarinic_agonists_as_innovative_therapies_for_Alzheimer's_disease/amp

Alzheimer’s and Parkinson’s Disease: Similarities and Differences (Aarsland and Weintraub have AVXL affiliation)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147932208

Autophagy and mitophagy in ALS.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147418161

Angelman Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147200990

dadofmarcmax on treatment of epilepsy with Anavex platform drugs:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=127872231
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=131111781
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144438361
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135019599
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135028269

A2-73 for macular degeneration
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342276

Huntington's Disease and aging mitochondria:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145684759
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145684899
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145685427

Diabetic market:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145572335

Psychiatric disease:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145559580

Normalization of hypertension - peer reviewed in January 2018
https://www.anavex.com/anavex-life-sciences-reports-potential-normalization-of-hypertension-with-anavex2-73-published-in-the-journal-of-clinical-hypertension/

Causes of CVD, mitochondrial dysfunction, oxidative stress and neuroinflamation:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146829394

Anavex 2-73 and/or Anavex 3-71 could be used to treat TBI Traumatic Brain Injury
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145739701
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147181730

Anavex also has Orphan Drug Designation for Infantile Spasms:
https://www.anavex.com/anavex-announces-u-s-fda-orphan-drug-designation-for-anavex-2-73-for-treatment-of-infantile-spasms/

Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147699893
The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147703240

___________________________________________________________________________________________________________________
MISC. DISCUSSIONS:

Falconer taking the temperature of the medical research community:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148589256

2015 mention of ERP results at five weeks:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148130307

Anavex 2-73 might show better results with younger patients than older patients.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148058285

2015 new discovery about the brain and the immune system:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148062119

“Enabling precision medicine with integrated genomic and clinical data” posted by Harald Hampel and kevli33
https://twitter.com/harald_hampel/status/1114590967531753472?s=21
https://azure.microsoft.com/en-us/blog/enabling-precision-medicine-with-integrated-genomic-and-clinical-data/

Anavex is not just a drug company - opinion from Lima4918
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147759921

Old brains and neurogenesis (from powerwalker).
https://www.statnews.com/2019/03/25/old-brains-make-new-neurons-possibly-protecting-against-alzheimers/

Top 20 CNS drug companies:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147869585

A new urgency for Expanded Access:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147906853

An excellent summary of why we are here from poster sokol:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143320176

Sokol on Anavex's international strategies:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144504285

Link to PeterKarol's blog:
https://piotrpeterblog.com/

Scientists rise up against statistical significance (from Biostockclub)
https://www.nature.com/articles/d41586-019-00857-9

Life expectancy in the US still continues to go down, 2018 graphic:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147424525

Short term milestone summary:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144330988

Comment on industry trends (link from PennyDouble)
https://www2.deloitte.com/us/en/pages/life-sciences-and-health-care/articles/us-and-global-life-sciences-industry-trends-outlook.html

Protein degradation disease treatments:
https://www.investors.com/news/technology/protein-degradation-eyed-pharmaceutical-companies-drug-development/

AI estimates brain age:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147255249

Orphan Disease Designation in Rett and Infantile Spasm
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146540508

Expansion of rare disease diagnostic codes (from nidan7500)
https://dravetsyndromenews.com/2019/02/04/icd-10-codes-really-important-to-rare-disease-patients-soon-up-for-fresh-consideration/

Missling has a strategy - comments from posters on that strategy:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144051610
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144350599
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145164402

Personal comments from falconer66a on the failure of traditional western medicine:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144979916

How the U.S. is failing its people in healthcare:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145076878

Brain cells from stem cells at Lund University:
https://www.lunduniversity.lu.se/article/new-method-grows-brain-cells-from-stem-cells-quickly-and-efficiently

Sokol with a 2016 perspective on potential Alzheimer's treatments:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144809093

2018 Shareholder meeting report:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140128467

___________________________________________________________________________________________________________________
BIG PHARMA AND POTENTIAL PARTNER DISCUSSION:

The “next wave” of BP’s being incubated now, in the form of small, smart, faster biotechs! 4/23/19 article:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148381829

Merck and 21st Century Medicine
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148109429

Merck and the Canadians team up:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148108335
https://www.eurekalert.org/pub_releases/2017-03/mu-npt031717.php

Roche and Genentech - a case study:
https://knowledge.wharton.upenn.edu/article/anatomy-of-a-merger-hostile-deals-become-friendly-in-the-end-right/

Why modern medicine is like the medieval church:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146539971

Below is a link to a 6-part article that shines a bright light on big pharma's influence in the market, research and fake news... rather revealing! (from basparks79)
https://articles.mercola.com/sites/articles/archive/2017/12/27/drug-safety-media-shaped-by-big-pharma.aspx

BIIB's problem with their Alzheimer's trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144801572

Bayer also bailing on R&D:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145174145

Why did Big Pharma bail on Alzheimer's trials early 2018? Possible Answer:
https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM596728.pdf
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145205259
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145214094
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145215823
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145214295

(see also MS section above)

___________________________________________________________________________________________________________________
TRIAL PROCEDURE:

U.S. FDA: 04/23/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148386035

AUSTRALIA'S TGA: 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148738081

OTHER COUNTRIES: 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148741442
___________________________________________________________________________________________________________________
LINKS TO OTHER SECTIONS:

IP Protection:05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148741585

AVXL -The Stock and the Market 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148741272

Genetic issues- sex and more 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148740737

SLEEP 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148740357

MOA and MEDICAL SCIENCE DISCUSSION 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148740172

GUT and BRAIN - barrier and permeability 05/10/19
https://investorshub.advfn.com/boards/edit_msg.aspx?message_id=148739064

Anavex Partners 05/10/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148740825

The People of Anavex 5/09/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148384976

3-71 Discussion 04/11/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148170998

Elder Care Crisis:03/04/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147273055

PRESS AND THIRD PARTY 03/17/19
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147597266