Anavex Life Sciences Corp (AVXL)

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Can A2-73 be an effective therapy for macular degeneration?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283661/

Abstract
This review discusses recent advances towards understanding the sigma-1 receptor (S1R) as an endogenous neuro-protective mechanism in the retina, a favorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors, as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retinal diseases such as glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD), and ultimately, blindness. The S1R protein is found essentially in every retinal cell type, with high abundance in the ganglion cell layer.