Anavex Life Sciences Corp (AVXL)

[XenaLives]

Compiled:GENETIC ISSUES - SEX and more 05/10/19
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GENETICS INFORMING TRIALS AND PRACTICE:


Evolution of clinical trials in multiple sclerosis
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148140606

FDA is now testing Real-World Evidence and comparing to randomized controlled trials:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148145719

2018 Conference presentations on pharmacogenomics epidemiology:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148156807

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GENETICS:

CRISPER discovery of likely MOA for 2-73:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144274561

DNA and BIOMARKERS (From Mikesc)
https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-016-0284-4

Apoe4 and Alzheimer's
https://medicalxpress.com/news/2016-08-scientists-reveal-people-apoe4-gene.html
https://www.snpedia.com/index.php/APOE

Anavex 2-73 Won’t Be “Gene Therapy;” Better (from falconer66a)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147087396

Health Conditions Related to Genetic Changes
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636445

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EPIGENETICS:

Anavex sigma-1 receptor agonists may treat epigenetic damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147090448

Mitochondrial dysfunction, disease pathology and epigenetics:
https://learn.genetics.utah.edu/content/epigenetics/inheritance/

Epigenetics and Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147643763

Epigenetic change:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148594441
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147910951
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147927639
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147906404
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147900786
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142496828

Why SSRI's are a FAIL:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039

Fluoride, Epigenetic change and Alzheimer's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147640105

Importance of the COMT gene:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147635325
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636055

Childhood abuse, the COMT gene and anger:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039

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SEX DIFFERENCES:

Men, Women, Alzheimer's and gene expression - (from raja45185)
https://www.asianage.com/life/health/060519/new-drugs-to-target-alzheimers.html

Do women have "younger" brains? (from baltimorebullet)
https://www.mprnews.org/story/2019/02/05/npr-scans-show-womens-brains-remain-youthful-as-male-brains-wind-down

Women and Alzheimers:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934418/
https://www.alz.co.uk/sites/default/files/pdfs/Women-and-Dementia.pdf

Sex hormones and womens' mental health:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148139054

Genetic Mutations & Estrogen Metabolism (COMT)
https://peacewithendo.com/2015/04/genetic-mutations-estrogen-dominance.html

The elegance of the progesterone theory:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147783390

The benefits of HRT, if initiated early enough in healthy women, are far greater than the potential adverse effects.
https://www.mja.com.au/journal/2009/190/6/benefits-oestrogen-following-menopause-why-hormone-replacement-therapy-should-be

More on hormone replacement history:
https://www.forbes.com/sites/forbesbooksauthors/2017/04/16/the-long-and-misunderstood-history-of-hormone-replacement-therapy/#47999b23667c

Progesterone:
https://investorshub.advfn.com/boards/read_msgs.aspx?board_id=11474&NextStart=175189&BatchSize=20

Women and Benzodiazepiens:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145578631

Women and choline:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146528112
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146530875

MS and gender bias
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145789105