Anavex Life Sciences Corp (AVXL)

[georgejjl]

Anavex 2-73 and/or Anavex 3-71 could be used to treat TBI Traumatic Brain Injury

Think NFL, college and highschool football, etc.

Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.
Dong H1,2, Ma Y2, Ren Z3, Xu B4, Zhang Y2, Chen J2, Yang B5.
Author information
Abstract
Traumatic brain injury (TBI) remains a significant clinical problem and contributes to one-third of all injury-related deaths. Activated microglia-mediated inflammatory response is a distinct characteristic underlying pathophysiology of TBI. Here, we evaluated the effect and possible mechanisms of the selective Sigma-1 receptor agonist 2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate (PRE-084) in mice TBI model. A single intraperitoneal injection 10 µg/g PRE-084, given 15 min after TBI significantly reduced lesion volume, lessened brain edema, attenuated modified neurological severity score, increased the latency time in wire hang test, and accelerated body weight recovery. Moreover, immunohistochemical analysis with Iba1 staining showed that PRE-084 lessened microglia activation. Meanwhile, PRE-084 reduced nitrosative and oxidative stress to proteins. Thus, Sigma-1 receptors play a major role in inflammatory response after TBI and may serve as useful target for TBI treatment in the future.

https://www.ncbi.nlm.nih.gov/pubmed/26228028

Read the related paper at the following link:

http://www.cognision.com/wp-content/uploads/2018/09/ERP-for-Diagnosis-and-Prognosis-of-Traumatic-Brain-Injury-9-18.pdf

Good luck and GOD bless,

George