Friday, May 05, 2017 2:03:22 PM
Epilepsy is not just about seizures. I view it as a spectrum of many different types of presentations. Epilepsy also involves personality changes, changes in cognition, changes in sleep, changes in coordination and mood, etc. Epilepsy can be classified into different categories: 1) focal epilepsies – there is a region of the brain or regions of the brain that are hyperexcitable and capable of seizing, 2) generalized epilepsies – whole brain involved with seizures, 3) epileptic encephalopathies – lennox gastaut syndrome, West Syndrome, Dravet syndrome, Rett syndrome – etc – that have both generalized and focal seizures, etc.
Treatment of epilepsy involves management of seizures as well as management of the mood/sleep/personality disorders that often times occur. At present, the goal of antiseizure drug treatment is to use medications that are either pro-inhibitory or anti-excitatory. In this sense, all of the medications must be able to cross the blood brain barrier and with this quality – many AEDs have some untoward side effects.
While epilepsy itself can create difficulties with cognition (most commonly short term memory loss, attention/concentration deficits), the antiepileptic drugs (AEDs) contribute to cognitive dysfunction as well. For example, commonly prescribed medications for seizure control: phenytoin, valproic acid, zonisamide, topiramate, etc all are known to be associated with cognitive side effects. Some of the newer agents – lamotrigine, lacosamide, eslicarbazepine, levetiracetam, brivaracetam may have less effects on overall cognition.
With many refractory epileptic patients, dual, triple or more AED drug combination therapy may play a role in getting seizures under control. In this population, often times high doses of medications are used and with that, there are more chances of untoward side effects. The role of an epileptologist like myself is to find a good balance between optimal seizure control and side effects as the goal of care is to improve the quality of life for patients.
With Anavex’s approach, it seems that they would like to use 2-73 or 19-144 as an adjunct with lower doses of standard antiepileptic medications in order to potentiate the effectiveness of the dedicated antiepileptic medication, prolonging its effect at the channel/receptor it is meant to bind to, and allowing for further cell membrane stabilization in order to decrease neuronal excitability.
With this approach, it would seem that Anavex is making attempts to show efficacy with its use as adjunct to all antiepileptic medications. Perhaps – combining 19-144 or 2-73 with standard AEDs in a refractory epileptic patient may contribute to decreased seizure frequency and allow for improvement in quality of life.
Once more information is publicized by Anavex- I will be sure to make some time to discuss more about the science behind the medications relative to epilepsy care. I look forward to future progress by Anavex. Good luck to all longs!
Recent AVXL News
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/12/2024 09:45:00 AM
- Anavex Life Sciences to Present at the Noble Capital Markets Virtual Healthcare Equity Conference • GlobeNewswire Inc. • 04/11/2024 11:30:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/09/2024 09:45:00 AM
- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 04/02/2024 09:45:00 AM
- Lost Money on Anavex Life Sciences Corporation(AVXL)? Join Class Action Suit Seeking Recovery - Contact The Gross Law Firm • PR Newswire (US) • 03/29/2024 09:45:00 AM
- Investors who lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 03/26/2024 09:45:00 AM
- Anavex Life Sciences to Present at the 23rd Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 03/25/2024 11:30:00 AM
- The Gross Law Firm Notifies Anavex Life Sciences Corporation Investors of a Class Action Lawsuit and Upcoming Deadline • PR Newswire (US) • 03/22/2024 09:45:00 AM
- Anavex Life Sciences Initiates Placebo-Controlled U.S. Phase 2 Clinical Trial of ANAVEX®3-71 in Schizophrenia • GlobeNewswire Inc. • 03/18/2024 11:30:00 AM
- Anavex Life Sciences to Present at the 44th Annual TD Cowen Health Care Conference • GlobeNewswire Inc. • 02/26/2024 12:30:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:05:18 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:04:32 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:04:31 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:03:48 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:03:06 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/07/2024 09:31:07 PM
- Anavex Life Sciences Reports Fiscal 2024 First Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 02/07/2024 12:30:00 PM
- Anavex Life Sciences to Announce Fiscal 2024 First Quarter Financial Results on Wednesday, February 7th, 2024 • GlobeNewswire Inc. • 02/01/2024 12:30:00 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 01/25/2024 10:01:34 PM
NanoViricides Reports that the Phase I NV-387 Clinical Trial is Completed Successfully and Data Lock is Expected Soon • NNVC • May 2, 2024 10:07 AM
ILUS Files Form 10-K and Provides Shareholder Update • ILUS • May 2, 2024 8:52 AM
Avant Technologies Names New CEO Following Acquisition of Healthcare Technology and Data Integration Firm • AVAI • May 2, 2024 8:00 AM
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Cannabix Technologies to Deliver Breath Logix Alcohol Screening Device to Australia • BLO • Apr 30, 2024 8:53 AM
Hydromer, Inc. Reports Preliminary Unaudited Financial Results for First Quarter 2024 • HYDI • Apr 29, 2024 9:10 AM