Sunday, September 23, 2018 3:09:36 AM
From discussions this spring:
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Doc, it's great that Dr Lisak is an acquaintance of yours and I did not detect your concern about the quality of his research with 2-73 other than it has not been peer reviewed to our knowledge at this point. One of our more respected board contributors reported a link with Biogen and WSU's Nuerological program some time ago, The Neurology Department serves over 3000 MS patients making it one of the largest MS Centers in the US and possibly the world. I'll look up those links and pass them on.
Beyond the known link with Anavex, Biogen and WSU in MS research, the question of the duration of the MTA puzzles many, As you point out that with the meager information from the PR on the MTA, the results from the Biogen Lab should have been known some time ago. So, given Biogen's focus on finding an effective remyelination drug (as stated plainly in the "lab video") and the failure of their prime in-house remyelination candidate, Opicinumab, in an optic nerve P2 trial, it seems that the results of the MTA may appear to be positive. What complicateds the picture is that 2-73 is a direct competitor to their Alzheimer's drug candidate, Aducanumab, now in a 2700 patient, 20 country P3 trial targeting ABeta Plaque (due to report in 2019/2020). Thus 2-73, if it turns out to have MS and AZ efficacy, is either Biogen best hope or worst nightmare depending on what they do with it. They apparently are not at the point of offering Chris Messling an attractive offer possibly waiting on our AZ P3 or have made an low ball offer which CM has turned down. As a historical perspective, Biogen paid Elan $3.25B plus royalties for the remaining 50% interest of Tysabri , one of their leading MS drugs in 2013. Biogen's MS line up of drugs brings in over 70% of the company's revenue but, is under severe attack from competitors. And, their new drug Spinraza for spinal muscular atrophy released in 2016 (treatment cost $750,000) is facing FDA approval of a similar drug from Norvartis. So where does Biogen go from here?
IMHO, They will delay a serious offer pending 2-73 success in one or more of its 3 trials this year or a possible poor results of the Aducanumab trial. 2018 will tell the tale.
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 26th Annual Global Investment Conference 2024 • GlobeNewswire Inc. • 09/03/2024 11:30:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/06/2024 09:21:05 PM
- Anavex Life Sciences Reports Fiscal 2024 Third Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/06/2024 11:30:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Third Quarter Financial Results on Tuesday, August 6, 2024 • GlobeNewswire Inc. • 08/01/2024 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/30/2024 09:20:53 PM
- Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference • GlobeNewswire Inc. • 07/30/2024 11:30:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
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