Anavex Life Sciences Corp (AVXL)

[Investor2014]

Also it say Anavex has ODD in Epilepsy. That page is a mess. Anavex have ODD for A2-73 in Rett and Infantile Spasm - perhaps they equate that with Epilepsy - fair enough I guess.

ODD also for A3-71 in Frontotemporal Dementia.

Btw. NEW YORK, NY – June 22, 2016

An infantile spasm is a specific type of seizure seen in an epilepsy syndrome of infancy and childhood known as West Syndrome. West Syndrome is characterized by infantile spasms, developmental regression, and a specific pattern on electroencephalography (EEG) testing called hypsarrhythmia (chaotic brain waves). The onset of infantile spasms is usually in the first year of life, typically between 4-8 months. The seizures primarily consist of a sudden bending forward of the body with stiffening of the arms and legs; some children arch their backs as they extend their arms and legs. Spasms tend to occur upon awakening or after feeding, and often occur in clusters of up to 100 spasms at a time. Infants may have dozens of clusters and several hundred spasms per day. Infantile spasms usually stop by age five, but may be replaced by other seizure types. Many underlying disorders, such as birth injury, metabolic disorders, and genetic disorders can give rise to spasms, making it important to identify the underlying cause. In some children, no cause can be found.

Infantile spasms occur in roughly 2-3 per 10,000 live births, with peak incidence at 6 months of age and less than 10% of cases presenting after 12 months of age. Neurological and/or developmental outcomes in patients with infantile spasms are usually poor. Children with symptomatic spasms more frequently exhibit neurological deficits and cognitive and developmental delays.