Why does Anavex 2-73 have effects on seemingly different neurodegenerative disorders? What makes it so special?
Approximately 3 years ago, after I sold off all of my NVIV (with a healthy gain), I bought AVXL and, over time, have steadily added to my shares outside of a sell off of some in 2017 that I bought back earlier this year.
I started posting here in 2015- at that time after a bit of DD on the background science (see Hashimoto et al on PubMed searching of "chronic neuroinflammation and sigma 1 receptor" and related articles) - I understood that attacking the primary pathophysiological mechanism to many (if not most) neurodegenerative disorders - the nebulous chronic neuroinflammation - will be the key to solving the mystery of neurodegenerative disorders in general.
While the "amyloid hypothesis" was a good start at solving the mystery - it only seemed to address one aspect of a multifaceted neuroinflammatory process. Clearance of protein aggregates, in essence, can help but only to a small degree initially before the other aspects of chronic neuroinflammation overload the overall complicated feedback loops involved.
2-73, I believe, acts to switch "off" the on/off mechanism that regulates inflammatory cascades. Hence - it seems to have "broad spectrum" potential for numerous, seemingly different, neurological disorders that all share the commonality of being related to a chronic neuroinflammatory pathophysiology.
I have written numerously about my believe in posts past but want to share with you a very interesting poster I came across today - for the science minded found here:
The poster is divided between the left ("proinflammatory") and right ("antiinflammatory").
LEFT: Aberrant synaptic pruning (? autism related, epilepsy related, genetic disorders related), Demyelination and Axonal Degeneration (MS, dementia(s), ALS, etc), Modulation of BBB Permeability/Immune Cell recruitment (multiple neurological and non-neurological immune related disorders) all occur with inflammation.
RIGHT: Immune-Mediated Aggregate Removal, Cellular Repair and Regeneration - ("restoration of cellular homeostasis") occur once the inflammatory switch is turned off - allowing for body self healing, so to speak.
The past 2 years with silence and minimal information has been frustrating but with the little tidbits we have been getting, nothing has changed from the standpoint that - the scientific basis for 2-73's activity is still yet to be refuted. Now - big presentations lie ahead of us with this CTAD, in my opinion, being THE MAJOR PRESENTATION that we have been waiting for since 2015. This CTAD, in my opinion, will be the herald event that starts the flow away from "amyloid hypothesis" and moves it towards the "restoring of cellular homeostasis". Anavex, in my opinion, will be the first to take the lead.
You may call this hype - I call this studied common sense.
Of course, this is all my own opinion. Biostockclub, sokol, nidan, falconer, ffrol (yes, him) and plenty other posters here all are seemingly on the same page of thought as I am, at present.
Science is slow, changing the course of scientific thought is even slower but when change happens, it will be sudden, it will be quick and it will be all-encompassing.
Perhaps this is why we have been/are being held down for so long. Too much money and vested interest from very wealthy and very influential players in this "game" will lose too much when the change will happen. It WILL be Sudden and unexpected and unlikely to occur exactly on the day of CTAD.
The symphony starts at CTAD but there are 4 movements in this one - the fun starts at the end of the symphony.
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