Anavex Life Sciences Corp (AVXL)

[XenaLives]

Falconer comments from way back when, see linked post:

falconer66a Friday, 12/01/17 03:29:47 PM
Re: OFP post# 132558 Post # 132561 of 169076

Tell Us, If Fits Subside Quickly, Does Anavex Work?

Please, render for us your cogent explanation should the following occur.

If in the upcoming Rett trial of little girls with this neurological condition, fraught with, among other symptoms, frequent epileptic fits and poor muscle control, Anavex 2-73 is administered blindly, in orange juice, apple sauce, or otherwise in a form the little girls cannot detect, and in say, in just three weeks of this, their mothers note that their frequent episodes of epileptic fits and poor muscle control markedly abate, would this be any indication the drug has authentic efficacy?

How should we unknowing AVXL shareholders react to some mother who might post here, "Hey, my little Susie has Rett, and after a month in that Anavex study no she longer has fits, and she's starting to walk normally!"

Without a proper two-armed study, real-drug and placebo, how could the upcoming Rett trial yield any scientifically valid results?

And, it's only for three months. Is that long enough to test a drug acting on a from-birth genetic anomaly?

Like yourself, we should be wary, should we not? Guide us. How should we interpret any interim results in any of the upcoming Anavex 2-73 clinical trials. We all messed up with the Australian study. We need guidance more so now. Most of us bought some AVXLs. Pretty risky, that was.

falconer66a Tuesday, 11/28/17 10:08:39 PM
Re: Batermere post# 132179 Post # 132184 of 169077

Again, Rett Results Will Be Hard To Confine

Interesting the note in a posting below that girls being selected for the Rett trial have to display sufficient numbers of daily seizures to be enrolled.

That clearly reveals that seizure control or suppression is the target outcome of Anavex 2-73 in the upcoming 3-month trial.

Now, just how difficult will it be to quantify a reduction in seizure events in the girls in the study? Will blood have to be drawn and analyzed? Will electrodes have to be stuck on the girls and electromagnetic activity of the brain digitally charted and analyzed? Perhaps.

But, in fact, the mothers of every one of those little ladies will know in a day or two when, simply, their little girls lived a day or two without seizures. Useful assessment of Anavex 2-73 efficacy in seizure reduction in girls with Rett syndrome genomes will be rendered by motherly perceptions of the well-being status of their girls. Mothers know.

I'm not aware of the typical frequencies of seizures in Rett syndrome girls. But let's say it's once a day. How, then, will mothers react when they notice, say, in the fourth week of the trial, their girls went 7 days without a seizure? Will they think (as some here would), "Well, that's interesting. But who knows? Can't be that drug Little Susie is taking. Must be just chance. I'll keep quiet about this and won't say a thing until the trial is over. What could I know? I'm not a doctor."

No, Susie's mother will be telling all her friends that the drug is actually starting to work, that her girl now has the chance to live a normal life.

At that point, will anyone knowing of this post a message here, telling the whole world?

Let's see.

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=136500338