Anavex Life Sciences Corp (AVXL)

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More on A2-73 gender bias:

This is referencing MS(!):

“Gender: MS is at least two to three times more common in women than in men, suggesting that hormones may also play a significant role in determining susceptibility to MS. And some recent studies have suggested that the female to male ratio may be as high as three or four to one.”

https://www.nationalmssociety.org/What-is-MS/Who-Gets-MS

Additionally, the intermittent dosing regimen, which I believe is to account for progesterone production knocking out the S1r action once cortisol levels drop off as the restoration takes place in the brain has a very intriguing clue in the strong responders:

We know about 5 of the 6, or 7. Of those, there is Ern Heaven, the golfer, and the one who sat for his driver’s exam. 3 males.
The artist and piano player were females. Also, I believe a responder began to travel again briefly and I seem to recall that shopping at grocery stores was either the same patient or a separate patient (I can try to go back to get the precise information on what has been published.) Also, in the patent application for intermittent dosing, the examples cited of how the drug regimen may work uses 3 males and 2 females. These could actually be close to what has been seen in the initial trial extension. Strange to use fictitious examples of more men than women when the prevalence does not mirror this - maybe it’s because the results might be in line with this.

The point is: if the incidence of women to men sufferers is 2:1 women, the strong responders do not reflect this in the response to the drug. Unless...you accept the theory that cortisol levels switch off sex hormones and that the drug restores balance. In that case, males would resume production of higher levels of DHEA - a sigma 1 r agonist, in addition to A2-73 and they would respond more favorably, whereas, females, would produce progesterone when restored, which inhibits S1r and would counteract the effect by knocking out the receptor unless taken off the med allowing cortisol to resume.

The interesting thing about the higher incidence of MS in females is that this dovetails the sigma 1 receptor being susceptible to sex hormones, specifically progesterone, and MS patients appear to become afflicted at a younger age - while progesterone is still at higher levels in the body.

This is food for thought as it would certainly fill in a puzzle piece if correct - S1r interference accounts for this disease as well, and it would be a tremendous coincidence if not which can not be accounted for without including the sex hormones. Key now: gender bias.

Go Anavex! (Steelers out, so cheering for this team all the way)
Wishing all a cognitive New Year,
Bio