Anavex Life Sciences Corp (AVXL)

[XenaLives]

Compiled:SPECIFIC INDICATIONS 09/29/19
-See also biomarker discussion in the main post.
____________________________________________________________________________________________
MULTIPLE DISEASE DISCUSSIONS:

Anavex disease targets discussed in February 2018 10Q:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150600833
https://www.marketwatch.com/press-release/10-q-anavex-life-sciences-corp-2018-02-07

Opportunities for treatment with Anavex 2-73 and/or Anavex 3-71

Image from AVXL presentation, clipped by georgejjl

From dadofmarcmax, the linked site has TONS of info:
"Why does Anavex 2-73 have effects on seemingly different neuro-degenerative disorders? What makes it so special? "
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143816865

Alzheimer’s and Parkinson’s Disease: Similarities and Differences (Aarsland and Weintraub have AVXL affiliation)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147932208

Anavex 2-73 for the treatment of type 2 diabetes mellitus, cardiovascular diseases, atherosclerosis, obesity, and fatty liver disease.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150732944
_______________________________________________________________________________________________
AIDS:

AIDS - is it an infammatory issue and not HIV?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151134596
____________________________________________________________________________________________
ALS:

Anavex 2-73 for the treatment of ALS
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150732376

A-beta could damage mitochondria-associated ER membrane function :(from jimmy_mcyoloswag)
https://www.ncbi.nlm.nih.gov/pubmed/25096627

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS
https://www.embopress.org/doi/10.15252/emmm.201606403

Link to guidance doc on ALS just released
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151298762

____________________________________________________________________________________________
ALZHEIMER'S:

Dr. Harald Hampel, MD, PhD, MA, MSc: Genomic Analysis of ANAVEX 2-73 in Alzheimer Disease Study 10/18, Videos:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148601340

SAB Jeffrey Cummings MD and others talking about Alzheimer's (from kevli33)
https://www.youtube.com/watch?v=36BQZURxY7Q

SAB member Jeffrey Cummings MD on current Alzheimer's treatments
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150272297
Jeffrey L. Cummings, MD, ScD: Agitation, Psychosis in Alzheimer Disease

Hampel: “What Electrophysiology Tells Us About Alzheimer’s Disease: A Window into the Synchronization and Connectivity of Brain Neurons - ScienceDirect”(from Investor2014)
https://www.sciencedirect.com/science/article/abs/pii/S019745801930329

Hampel: Revolution of Alzheimer Precision Neurology,Passageway of Systems Biology and Neurophysiology(from kevli33 )
https://content.iospress.com/download/journal-of-alzheimers-disease/jad179932?id=journal-of-alzheimers-disease%2Fjad179932

Pics illustrating Brain Atrophy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151322691

Choline Reported to Suppress Alzheimer’s Symptoms
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151405396

Hampel: “What Electrophysiology Tells Us About Alzheimer’s Disease: A Window into the Synchronization and Connectivity of Brain Neurons - ScienceDirect”(from Investor2014)
https://www.sciencedirect.com/science/article/abs/pii/S019745801930329

The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147703240

Youtube that explains the mechanisms of Alzheimer's and aging (from georgejjl) at 40 min there is a reference to 2-73:

The Devil Disease....A very good synopsis of medical science's progress with Alzheimer's. (from Talon38)
https://www.biospace.com/article/-a-devil-of-a-disease-the-current-alzheimer-s-pipeline

More Than a Quarter of a Trillion Dollars : Reports Underestimate Alzheimer’s Full Cost on Society
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150336272

The economiic impact of dementia:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148593001

Anavex 2-73 and/or Anavex 3-71 could save the USA Hundreds of $Billions yearly and $Trillions worldwide
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149158388

Stresses on Caregivers:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147069410

Scientists identify protein that makes women more susceptible to Alzheimer’s (from raja48185 )
https://www.thehealthsite.com/news/alzhiemers-scientists-identify-protein-that-makes-women-more-susceptible-677948/

Role of seizures in Alzheimer’s disease is gaining overdue attention (from raja48185 )
https://www.statnews.com/2019/07/19/alzheimers-role-of-seizures/

Amyloid ß oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149547318

Mitochondrial dynamics and transport in Alzheimer's disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150038868

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease (from kevli33)
https://www.alzheimersanddementia.com/article/S1552-5260(19)30077-9/fulltext

"Our paper on plasma amyloid beat 40/42 ration predicts cerebral amyloidosis in asymptomatic at risk individuals for AD has been published in Alzheimer's & Dementia"(from kevli33 quoting Harald Hampel tweet)
https://goo.gl/scholar/JZH7Zw

March 2019 discussion of ACTC begins here:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147409548

Anti-Tau Trials for Alzheimer’s Disease: A Report from the EU/US/ CTAD Task Force (from Kevli33)
https://www.ctad-alzheimer.com/files/files/Anti-Tau%20trials%20for%20AD%20-%20A%20report%20from%20the%20EU%20US%20CTAD%20Task%20Force.pdf

Basic biology concepts for Alzheimer’s disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=137348423


On titration of 2-73:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147635325
Possible partnering for Alzheimer's diagnosis and treatment protocol from tredenwater2
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145766313

U.S. Alzheimer's diagnosis is inferior:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148065564
Will it take 48 weeks to realize these endpoints?
https://investorshub.advfn.com/boards/read_msgs.aspx?board_id=11474&NextStart=178123&BatchSize=20

Possible causes of Alzheimer's summarized:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146243514


Paper on progression from MCI to Alzhimer's posted by Investor2014 (includes sleep)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762666/

Apoe4 and Alzheimer's
https://medicalxpress.com/news/2016-08-scientists-reveal-people-apoe4-gene.html
https://www.snpedia.com/index.php/APOE

African Americans and Alzheimer's
https://investorshub.advfn.com/boards/read_msgs.aspx?board_id=11474&NextStart=177836&BatchSize=20

Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease? (from Investor2014)
https://www.alzforum.org/news/research-news/could-disposing-damaged-mitochondria-treat-alzheimers-disease

Do we have a good chance to win in the "Oskar Fischer Project" ?
https://alzheimersnewstoday.com/2018/11/09/new-challenge-offers-prize-money-better-understanding-alzheimers/

-----------Current Medications and Alzheimer's-----------


Alzheimer's & SOC - too many patients exposed to drug interactions: French data:
http://english.prescrire.org/en/81/168/49338/0/NewsDetails.aspx


Macfarlane and Hammond Care CEO Stephen Judd on overmedication of elderly patients:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146079150

French healthcare system decides it will no longer reimburse for Donepezil and other Alzheimer's drugs.
http://english.prescrire.org/en/81/168/55126/0/NewsDetails.aspx

What does Donepezil do?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144744473

How does the body handle Donepezil?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145773592

Donepezil and kidney damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151153943
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151154283


Fluoride and Alzheimer's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147640105

-----------P2a Alzheimer's results-----------
Will be trying to move all 2a comments to this subset of remarks.

P2a Time passed
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150987700

Mayo Clinic researcher states that the P2a improved cognition and function:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149549864

Ariana’s AI provides evidence for 3 years clinical efficacy of ANAVEX®2-73 Alzheimer’s targeted therapy @CTAD2018
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150169508

Missling 2017 comment on blood concentration (from georgejjl):
https://www.mdedge.com/clinicalneurologynews/article/152595/alzheimers-cognition/development-sigma-1-receptor-agonist

Longitudinal 148-Week Update of ANAVEX®2-73 Phase 2a Alzheimer’s Disease Extension Study
http://www.arianapharma.com/wp-content/uploads/2019/03/ANAVEX2-73_CTAD_2018_Presentation_v2.pdf

Safety in the P2a
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150294751

Discussion of P2a trial dropouts:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144496759

Blood concentration seems to be important:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147596397

TempePhil analysis of corporate presentations, possible 208 wk data:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148154210

Comparison of published A2-73 AZ 57wk data to current AZ trial (from TempePhil)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148859931

-----------P2b Alzheimer's results-----------
Will be trying to move all 2b comments to this subset of remarks.

Seven additional trial sites recruiting of the Anavex Phase 2b/3 for the treatment of Early Alzheimer's disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150366467

Missling states that PET scans will be used in P2/3 trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143981335

P2b/3 dosage slide:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145842885

The company's stated timeline for Alzheimer's P2b/3:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144956279



-----------Alzheimer's specific diagnostics and biomarkers-----------
Alzheimer's diagnostics and biomarkers
Will be trying to move all such comments to this subset of remarks.

Alzheimer's biomarkers explained:
https://www.alzdiscovery.org/news-room/blog/alzheimers-biomarkers-explained

Current state of Alzheimer's fluid biomarkers. - Full Paper (from Investor2014)
https://link.springer.com/article/10.1007/s00401-018-1932-x
More on AD and sleep...as predicted... (from nidan7500)
https://alzheimersnewstoday.com/2019/03/15/brains-of-people-with-sleep-apnea-show-higher-burden-of-tau-protein-aggregates

Did ACTC consider new biomarkers for this Eisai study?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148730321

Cbdpotential on systems and reference to a 2017 paper by Harald Hampel:

A Precision Medicine Initiative for Alzheimer’s disease: the road ahead to biomarker-guided integrative disease modeling

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149737160

Discussion on 4/25/19 concerning new blood tests for Alzheimer's - read forward from here:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148425843

Model predicts cognitive decline due to Alzheimer’s, up to two years out
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150352411
https://investorshub.advfn.com/boards/replies.aspx?msg=150352411

On the difficulty in diagnosing Alzheimer's:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145129244

Blood test is 94% accurate at identifying early Alzheimer's disease (from georgejjl)
https://medicalxpress.com/news/2019-08-blood-accurate-early-alzheimer-disease.html
https://medicalxpress.com/news/2019-06-blood-alzheimer-disease.html
https://medicalxpress.com/news/2015-07-midlife-alzheimer-biomarkers-dementia.html

Alzheimer's specific sleep scale:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144847354&txt2find=caregivers

Might Anavex-facilitated Sleep Prevent Alzheimer’s? (from Falconer66a)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147042424

P300 Amplitude Discussion: See IP section and Partners section

What do Ahzheimer's and cancer have in common?
https://investorshub.advfn.com/boards/read_msg.aspx?WRmessage_id=149547553

New Markers For Alzheimer's Disease Could Aid Diagnosis And Speed Up Drug Development (from maverick_1)
https://www.npr.org/sections/health-shots/2019/07/04/738478841/new-markers-for-alzheimers-disease-could-aid-diagnosis-and-speed-up-drug-develop

Alzheimer's eye test to enter trial phase in hopes of diagnosing before symptoms appear
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149163374

Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says (from kevli33).
https://www.cnn.com/2019/06/24/health/dementia-risk-drug-study/index.html

High Cholesterol Linked to Alzheimer's Disease (from kevli33)
https://www.newsweek.com/high-cholesterol-linked-alzheimers-disease-1437215

Blood pressure and dementia study with a good video:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149079241

See also insomnia patent under IP, sleep section, and more in ERP in partners section.
Links at the end of this post

Vitamin D and Alzheimer's:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145586595

AI used to detect Alzheimer's in PET scans (from baltimorebullet)
https://kottke.org/19/01/ai-algorithm-can-detect-alzheimers-earlier-than-doctors

More on Amyloid PET AD diagnostics from Hampel tweet.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146598748

The Alzheimer Precision Medicine Initiative Journal of Alzheimer's disease:
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad181121

Improved Diagnostic for Alzheimer's - just perfect for Anavex 2-73:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148616412

____________________________________________________________________________________________
ALS:

Sig-1R, autophagy, and neurodegeneration has been recently shown in the context of ALS
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151316188&txt2find=ALS

Autophagy and mitophagy in ALS.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147418161

____________________________________________________________________________________________
ANGELMAN SYNDROME:

Angelman Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147200990
____________________________________________________________________________________________
AUTISM and FRAGILE X:

The cost:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151122754

Fragile X syndrome connected to mitochondrial dysfunction. (from Steady_T)
https://medicalxpress.com/news/2019-02-cell-component-breakdown-treatment-multiple.html

Fragile X is a growing concern (link from cninc):
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00564/full
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144971728

Will fragile x start trials soon?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146687514

Anavex 2-73 and the autism market:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147237001&txt2find=2016

Kaufmann paper on FragileX and Autism:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148178337

Glutamine Levels in Children with High-Functioning Autism
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151361805
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151190559

Autism and sleep...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149039440

Facts about autism spectrum disorder:(from georgejjl)
http://www.autism-society.org/what-is/facts-and-statistics/


____________________________________________________________________________________________
CARDIO VASCULAR DISEASE:


Causes of CVD, mitochondrial dysfunction, oxidative stress and neuroinflamation:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146829394


Normalization of hypertension - peer reviewed in January 2018
https://www.anavex.com/anavex-life-sciences-reports-potential-normalization-of-hypertension-with-anavex2-73-published-in-the-journal-of-clinical-hypertension/



____________________________________________________________________________________________
CHARCOT-MARIE-TOOTH DISEASE:


Charcot–Marie–Tooth disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150827467

____________________________________________________________________________________________
DIABETES:

Diabetic market:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145572335


____________________________________________________________________________________________
EPILEPSY:

Question of Epilepsy parnership:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147238816

PennyDouble reminds us, we have an expert on the SAB :
https://www.anavex.com/anavex-life-sciences-appoints-distinguished-researcher-neurology-epilepsy-scientific-advisory-board/

Seizures in multiple diseases:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151363168

GABA, Glutaminie and seizures:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151361805

The significance of adding Dr Andrew Cole MD authority on Epilepsy to Anavex SAB:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144358640

dadofmarcmax on treatment of epilepsy with Anavex platform drugs:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=127872231
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=131111781
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144438361
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135019599
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135028269


____________________________________________________________________________________________
FLOUROQUINOLONE TOXICITY:

Flouroquinolone toxicity:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150873186
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151055856

Fluoroquinolones Deplete Antioxidants
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150900058

Fluoroquinolones, benzodiazapenes, GABA, motochondiral damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146867900

A Delicate Balance: Fluoroquinolones Disrupt Cellular Homeostasis
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150872773
____________________________________________________________________________________________
HUNTINGTON'S DISEASE:

Protein Misfolding and ER Stress in Huntington Disease (from georgejjl)
https://www.frontiersin.org/articles/10.3389/fmolb.2019.00020/full

Huntington's Disease and aging mitochondria:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145684759
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145684899
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145685427

Protein Misfolding and ER Stress in Huntington's Disease (from georgejjl)
https://www.frontiersin.org/articles/10.3389/fmolb.2019.00020/full

BDNF, Sigma-1, and Huntington Disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149255300


____________________________________________________________________________________________
INFANTILE SPASMS:

Anavex also has Orphan Drug Designation for Infantile Spasms:
https://www.anavex.com/anavex-announces-u-s-fda-orphan-drug-designation-for-anavex-2-73-for-treatment-of-infantile-spasms/
____________________________________________________________________________________________
MACULAR DEGENERATION:

A2-73 for macular degeneration
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342276 ____________________________________________________________________________________________
MULTIPLE SCLEROSIS:

Bad medical practice causes harm:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151070464

Dr Lisak's preclinical of 2-73 in MS:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147244571

MS - needs more scientific development in order to support a successful 2-73 trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145845309
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145855079

Youtubes on Myelin:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145846058

MS is still on the table per 12/12/18 10K
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146069570

MS and gender bias
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145789105

Anavex - Biogen & MS
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135630393
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143729928
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143732818
https://investorshubAL.advfn.com/boards/read_msg.aspx?message_id=143734046
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144040837
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143735763
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147244426

____________________________________________________________________________________________
PARKINSON'S DISEASE AND PARKINSON'S DEMENTIA:

Lets do some math on the PDD Trial.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150879581

This Woman Can Actually Smell Parkinson's Disease Before It's Diagnosed
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150827225

Six additional trial sites recruiting of the Anavex Phase 2 Parkinson's Disease Dementia trial
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150366368

"SANTIAGO UNIVERSITY CLINICAL HOSPITAL is now marked closed."
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150368372

Trial listing Parkinson's on clinicaltrials.gov as of 12/13/18
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145772074
How the Parkinson's Dementia trial may help expedite Alzheimer's approval:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143580569

Announcement of Aussie PDD trial
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148578140

Parkinson's and the Gut (from Talon38)
https://www.fiercebiotech.com/research/new-evidence-shows-link-between-parkinson-s-disease-and-gut

From 2018 Research Report at Hammond Care (page 38)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150210585

Novel Treatment Opportunities Against Cognitive Impairment in Parkinson’s Disease with an Emphasis on Diabetes-Related Pathways (from georgejjl)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373401/

Listing of Spanish PDD trial sites:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149316525

Aussie PDD trial will evaluate sleep:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148934406

Scientists Are Warning of a Future Parkinson's Pandemic, And We Can't Ignore It (from Amateur17)
https://www.sciencealert.com/research-warns-of-a-pending-parkinson-s-pandemic-and-we-need-to-pay-attention

Parkinson's News Today announces trial with participation of MJF foundation from whippensaw:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144653898

Sokol on how 2-73 benefits PDD patients:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149155921

** EU and Spanish Trial **

EU Parkinson's trial info:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144654071

Spanish trial info:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144654240

Spanish info on Parkinson's trial as of 2/26/19
http://www.gacetamedica.com/especializada/comienza-la-segunda-fase-del-estudio-clinico-para-enfermedad-de-parkinson-con-demencia-asociada-MG1945349
English Translation:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147248343

Spanish publication mentioning Anavex PDD trial
https://issuu.com/parkinsonmadrid/docs/revista_70_issue/1?ff

From K9uwa aka John: Today in Parkinsons News Today ENROLLING NOW in Spain article.
http://parkinsonsnewstoday.com/2018/11/01/anavex-recruiting-parkinsons-dementia-patients-spain-anavex-2-73-trial/

Parkinson's researchers have asked for an extension:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147933240
http://wsw.com/webcast/cowen52/avxl/

Parkinson's endpoints cognition and motion
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145688901
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145689920

Spanish info on Parkinson's trial as of 2/26/19
http://www.gacetamedica.com/especializada/comienza-la-segunda-fase-del-estudio-clinico-para-enfermedad-de-parkinson-con-demencia-asociada-MG1945349
English Translation:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147248343

** Australian Trial **

January 19 AU governement allocated an additional $36.8 million for Parkinson's research.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148593663

Hammond Care to join in Parkinson's Dementia trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148578140

Australia has a 5 year plan for Parkinson's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148988597

Hammond Care to join in Parkinson's Dementia trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148578140


** Sleep, Science, and PDD **

New Sensor Technology Can Detect Medication Response Automatically for Parkinson’s Disease Patients
https://patientworthy.com/2019/04/24/sensor-technology-detect-response-parkinsons-disease-pd/

Sleep in Parkinson's disease -
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145233486

Biostockclub on Parkinson's dosage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144533102

More on Parkinson's and sleep (from nidan7500):
https://parkinsonsnewstoday.com/2019/03/13/study-factors-sleep-benefit-parkinsons-disease/

Apathy and Depression Linked to Sleep Disorder in Parkinson’s Patients, Study Finds
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148336025

Testing method to be used:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145428524

Dr. M. Angela Cenci Nilsson resulting study from the 2015 research grant
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148339012
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342120
PROFILE
http://www.academia-net.org/profil/prof-dr-m-angela-cenci-nilsson/1488381

Veronica Francardo
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148342376
Francardo May 2018 statement on effect of 2-73 in Parkinson's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=134044839

Anavex PR's from the Lund preclinical research on Parkinson's by Cenci-Nilsson and Francardo.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148343391

____________________________________________________________________________________________
PAIN:

Sigma-1 Chaperones for the Treatment of Pain, Neurodegerative Disorders and Substance Abuse (from raja4815)
https://www.youtube.com/watch?v=YXdGv112j70

RE: A-1066 for pain:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150867690
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150869708
____________________________________________________________________________________________
PSYCHIATRIC DISEASE:

Psychiatric disease:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145559580

PTSD
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151028144

Anavex 2-73 and/or 3-71 as a treatment for postpartum depression
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144995494&txt2find=71

Gulf War Syndrome - maybe some autophagy would help, 2014 article....
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150880662

The Loss of Glutamate-GABA Harmony in Anxiety Disorders(from Jonjones325)
https://www.intechopen.com/books/anxiety-disorders/the-loss-of-glutamate-gaba-harmony-in-anxiety-disorders
____________________________________________________________________________________________
RETT SYNDROME:

Video of Rett Syndrome Kids (from kevli 33)

The DSMB and the Rett trial (from IhidfromtheX)
http://people.musc.edu/~elg26/teaching/MCCR2015/Lectures/Lecture12_DSMBs/Whitehead-1999-Statistics_in_Medicine.pdf

From the principle investigator of AVATAR: (and kevli33)
https://www.neurologylive.com/clinical-focus/automated-epilepsy-diagnostic-monitoring-systems-effective
http://ccsmonash.blogspot.com/2017/06/welcome-to-professor-terry-obrien-new.html
https://www.researchgate.net/profile/Terence_OBrien

Professor Terry O'Brien running Rett trial at Alfred Health
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149294128
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149294230

Will 2-73 work better in younger Rett victims?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151362146

Rett and growth & nutrition. It seems that nutrition is a problem.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151404149

On Seizures in Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151387973

The Glutamate info is the heart of it all. These few paragraphs make the point.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151396481

Both efficacy endpoints, the Rett Syndrome Behaviour Questionnaire (RSBQ) and the Clinical Global Impression – Improvement (CGI-I) showed significant improvement with respect to baseline after 7 weeks of treatment. The RSBQ Total average scores improved from 50 to 34 points (2-tailed Wilcoxon signed rank test, p = 0.027) and the CGI-I scores were positively correlated with RSBQ Total scores at 7 weeks (2-tailed Spearman’s rho = 0.956, p = 0.003).

Discussion of Rett's measuments mentioned above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151278917
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151276909

Perhaps the origination for name of the "Excellence" study
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150913826

Anavex 2-73 might show better results with younger patients than older patients.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150963617

Titration related to each subject's size, weight and metabolism could increase the response and efficacy of Anavex 2-73.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150320324
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150320511

Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community: A Descriptive Review (from georgejjl)
https://www.mdpi.com/1422-0067/20/17/4160/htm

Gut microbial connection for Rett Syndrome identified in recent study shows our clinical trials are treading a solid path in providing the evidence of efficacy for 2-73. (from Talon38)
https://www.mdpi.com/1422-0067/20/17/4160

Success in Rett will(imo) open the door to Autism Spectrum Disorder
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151117793

2-73 vs Trofinetide in Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151182756
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151223993
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151407416

Observations on Rett trial results:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151161945 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151162899

Possible inference from mouse studies:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151206974

U.S. journalist Richard Engel parent of Rett Syndrome son:
https://www.today.com/parents/rett-syndrome-richard-engel-son-henry-s-milestone-life-special-t150348


Link to Herald Sun article on AVXL Alzheimer's and Rett trials, posted by TTav66
https://www.pressreader.com/australia/herald-sun/20190607/281655371571373

June 7 Pr on the Rett trial, mentions fast track:
https://investorshub.advfn.com/boards/readmsg.aspx?message_id=149293556

Rett Syndrome: A Focus on Gut Microbiota. (from georgejjl)
An important read
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343879/

Australian Rett Syndrom Trial starts May 9 2019 (from Greenspam3)
https://www.facebook.com/rettaustralia/
https://www.anavex.com/rett-syndrome-association-of-australia-and-anavex-life-sciences-announce-initiation-of-the-phase-2-avatar-clinical-study-in-patients-with-rett-syndrome/

On Missling's plan for Rett Trial:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148732543

"RettSyndrome.org updated their Clinical Trials information on 4/4/19 with the link below.
This will give the Rett Families a bit more information and encourage trial participation."
(Quoted and provided by Talon38)
https://www.rettsyndrome.org/file/press-releases/Anavex-doses-1st-Patient.pdf

Trial listing Rett Syndrome on clinicaltrials.gov as of 12/07/18
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145772107

Rett Syndrome prospects, trial update, and patent (from georgejjl )
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146683698
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146684425
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146720630

ANAVEX 2-73 Normalizes Hippocampal BDNF Expression
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148132992

For the first time a human disease — Rett Syndrome, the first identified epigenetic disease — has been linked to specific defects in the three-dimensional folding of chromatin. (from georgejjl)
https://www2.lbl.gov/Science-Articles/Archive/LSD-Rett-syndrome.html
see also:
https://www2.lbl.gov/Science-Articles/Archive/assets/images/2004/Dec-20/DLX5-Rett-Syndrome.pdf

Epigenomics and Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147643763

On the ambiguity in earnings call on Rett trials:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146678488
Response from runcoach:
https://investorshub.advfn.com/boards/replies.aspx?msg=146678488

FDA Revising ‘Draft Guidance’ on Developing Treatments for Rare Diseases (from nidan7500)
https://rettsyndromenews.com/2019/01/30/fda-revising-draft-guidance-on-developing-treatments-for-rare-diseases/
Levetiracetam possible for Alzheimer's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147247821

Anavex 2-73 synergism with levetiracetam for treatment of Rett syndrome and epilepsy.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147246715

Rett syndrome testing via auditory event:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146263432

Rettsyndromenews.com on the 2-73 trial
https://rettsyndromenews.com/2019/01/08/phase-2-trial-anavex-2-73-rett-syndrome/

Anavex Life Sciences Announces FDA Approval of IND for Phase 2 Trial of ANAVEX®2-73 in Patients with Rett Syndrome
Study will incorporate genomic precision medicine ANAVEX®2-73-specific biomarkers
https://www.anavex.com/anavex-life-sciences-announces-fda-approval-of-ind-for-phase-2-trial-of-anavex2-73-in-patients-with-rett-syndrome/

Rett Syndrome trial and endpoints announced on Clinicaltrials.gov 11/29/18 (Thanks to poster Abel and Cabel)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145164109

Info on Dr. Kaufmann who will be running the 2-73 Rett Syndrome trial and who is now CMO for Anavex:
http://gcbcenter.kennedykrieger.org/staff.jsp

2016 presentation on Rett Syndrome
https://anavex.com//wp-content/uploads/ANAVEX-2-73-as-a-Potential-Treatment-for-Rett-Syndrome.pdf

2017 presentation on Rett Syndrome

Rett Syndrome in adults:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145216562
http://www.anavex.com/wp-content/uploads/2017/05/Anavex-Angelman-FX-Rett-conference-update-2017-May-2017-final.pdf

Rett Syndrome & Fragile x - they are are related:
From Talon38 (post 173314) "NIH's updated (2 days ago) information on Fragile X. Notice both the similarities and differences (predominantly a male diseases). Fragile X is one of 2-73's pipeline targets as is Infantile Spasms and Angelman's. Not a stretch to believe that Tayo Fadiran has been working CDER and NIH for a combined clinical trial to these orphan diseases. With positive Rett Syndrome results, that may come to fruition. The 2-73 "train" is gathering momentum!"
https://ghr.nlm.nih.gov/condition/fragile-x-syndrome

Rett Syndrome Study Design a link Natural History Study Publications from Investor2014:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144701675
https://www.rettsyndrome.org/for-researchers/nhs-research-publications

Discussion of Rett Trial Design why it is structured the way it is:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144356675
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145205166

On the disease phases of Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144701046

Will the trial be moved to Australia?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144362026

On Rett Syndrome and the M4 Receptor from Investor2014:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144347886

Other Rett Syndrome related posts:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144357506
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135703149

Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome
https://www.sciencedirect.com/science/article/pii/S0149763418306900 (from Investor2014)

Talon38 provided this NIH link on Rett Syndrome:
https://ghr.nlm.nih.gov/condition/rett-syndrome


Paper on Rett Syndrome treatment procedures:
https://pdfs.semanticscholar.org/c2c8/1063888a7aecffd3b1fe74a7b67496b2554f.pdf

____________________________________________________________________________________________
SCHIZOPHRENIA:

from kevli33

Purpose of the above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150169319
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150169571

Antipsychotics, also known as neuroleptics, are a class of drugs used to treat psychiatric disorders.. (from kevli33 )
https://youtu.be/nKkIh1B2Js8
A
Aug 28, 2019, 02:16am
The Rise Of Direct To Consumer Precision Health
'We are operating within a healthcare system that is reactive, inefficient, and overly reliant on trial and error.'
https://www.forbes.com/sites/columbiabusinessschool/2019/08/28/the-rise-of-dtc-precision-health/#7283f9fe6f6a

____________________________________________________________________________________________
TBI:


Anavex 2-73 and/or Anavex 3-71 could be used to treat TBI Traumatic Brain Injury
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145739701
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147181730

Protein tangles linked with dementia seen after single head injury
(from Kevli33)
https://www.imperial.ac.uk/news/192788/protein-tangles-linked-with-dementia-seen/?utm_medium=email