Anavex Life Sciences Corp (AVXL)

[TempePhil]

SteadyT, followup to your good link...

You posted a good link to Trofinetide's Rett study results:
https://n.neurology.org/content/92/16/e1912

This link's Table 3, helps to put the Anavex Rett data in context.
Looking at table 3 (view pop up, at bottom left select table 3 of 3)
we can see the Trofinetide results with placebo and dosages.
Here is the top part of that table:


Note the Trofinetide trial was with 82 participants, and placebo controlled. The first 14 days (D14) obtained baseline data, and the full study was for 54 days (D54).

The 200mg/kg dose arm shows RSBQ score dropping 6.7, while the placebo arm drops 2.3.
See the red underlined interesting data.

Comparing these to the Anavex scores that dropped 16 points, we can see:
1) A2-73 provided a much stronger signal, >2x that of Trofinetide!
2) The placebo affect accounts for a drop of only 2.3 points. Assuming similar placebo affect with A2-73, there is still a very strong signal!

A2-73 DROPPING SCORES 16 POINTS IS STILL GREAT NEWS!