Anavex Life Sciences Corp (AVXL)

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"Some" deep dive DD regarding AD. (SAB member Jeffrey Cummings MD)

July 31, 2019 / Brain & Spine
What Kind of Treatments Are Being Developed for Alzheimer’s Disease?
Despite some disappointments, the pipeline isn't dry

https://health.clevelandclinic.org/what-kind-of-treatments-are-being-developed-for-alzheimers-disease/

Research in context

1.Systematic review: There is a high rate of failure of drug development for Alzheimer's disease. New treatments are urgently needed, and review of the drug development pipeline can improve our understanding of how best to advance new therapies. We reviewed all drugs currently in clinical trials for Alzheimer's disease listed in the federal government database clinicaltrials.gov.
2.Interpretation: We showed that there are 132 agents in clinical trials for the treatment for Alzheimer's disease. Ninety-six of these drugs are disease-modifying agents intended to change the underlying biology of Alzheimer's disease. Nineteen of the drugs are intended to be cognitive enhancing agents, and 14 are being developed for the treatment of neuropsychiatric and behavioral symptoms. We provide an overview of drugs currently in clinical trials for Alzheimer's disease.
3.Future directions: Progress is being made in terms of defining new targets for the treatment of Alzheimer's disease, developing new agents, introducing innovative clinical trial designs, incorporating a broader range of populations in clinical trials, and developing new biomarkers that provide insight into the impact of emerging therapies. Improvements in drug development success rates are anticipated.

https://www.trci.alzdem.com/article/S2352-8737(19)30029-0/fulltext