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Current Issues and Limitations of other "Biomaterials" as

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boston745 Member Level  Sunday, 03/03/19 05:45:38 PM
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Current Issues and Limitations of other "Biomaterials" as compared to Silicon Nitride

Quote:
The medical-care system continues to promote the idea that you can cut out body parts and insert metal or plastic at will. Why? It’s a huge and big-bucks industry worth in the aggregate hundreds of billions of dollars. However, there is a problem called wear debris, and no matter how you design these implants, wear will occur. In addition, if you continue to advertise these devices to be used in younger and healthier patients who are more active, more wear will happen. Hence, more wear equals more particles, and more particles equals more bad stuff floating around in patients!




How medical device harm is concealed

Everything You Need to Know About the Implant Files


Infections in Orthopedics, a growing problem

No single implant material tested is able to reduce bacterial adherence of all of the pathogens tested.

Metals, Inflammation, & Autoimmunity

AUTOIMMUNE DISEASES AND METAL IMPLANTS AND DEVICES


Titanium

Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H2O2, Albumin, & porous Titanium

Heavy metal: Titanium implant safety under scrutiny

The Distribution and Pro-Inflammatory Impact of Titanium Debris Accumulation in the Peri-Implant Enviornment

Serum titanium, niobium, and aluminum levels after instrumented spinal arthrodesis in children.

Titanium implants and silent inflammation in jawbone—a critical interplay of dissolved titanium particles and cytokines TNF-a and RANTES/CCL5 on overall health?

Analysis of samples revealed a significant increase in hair and nail titanium levels

Roughening surface of Titanium implants leads to increase corrosion and biofilm formation

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants

The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice.


PEEK

Quote:
Dr. Khoi Than, said, "Hundreds of thousands of PEEK implants are placed in patients' necks every year, and our work verifies my suspicion that many of them are not healing.


Pseudarthrosis following single-level ACDF is five times more likely when a PEEK interbody device is used

In the PEEK group, vertebral osteolysis was noted in 60 % of the cases with nonunion

The degree of peri-implant osteolysis induced by PEEK, CoCrMo, and HXLPE wear particles: a study based on a porous Ti6Al4V implant in a rabbit model

Quote:
The absence of posterior fixation in combination with lower stiffness and the hydrophobic characteristics of PEEK probably lead to insufficient initial stability, creating suboptimal conditions for bony bridging, and thus solid fusion.


PEEK Cages in Lumbar Fusion: Mid-term Clinical Outcome and Radiologic Fusion - Depuy Spacer

Are Periprosthetic Tissue Reactions Observed After Revision of Total Disc Replacement Comparable to the Reactions Observed After Total Hip or Knee Revision Surgery?


ZTA

Characterisation and Biological Impact of Wear Particles from Composite Ceramic Hip Replacements

Mechanistic Study of the Wear of Ceramic Heads by Metallic Stems in Modular Implants

Zirconia phase transformation in retrieved, wear simulated, and artificially aged ceramic femoral heads

Ceramic prosthesis surfaces induce an inflammatory cell response and fibrotic tissue changes

Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys

Zirconia Nanoparticles-Induced Toxic Effects in Osteoblast-Like 3T3-E1 Cells - TiO2 NP exhibited similar toxic effect

Cobalt Toxicity, An overlooked Cause of Hypothyroidism - patient with Ceramic-on-Ceramic right Hip Implant and a large amount of metal debris


Cobalt-Chromium

Stephen Tower - Wear & Corrosion of Chrome-Cobalt Hip Implants

PET Brain Imaging in Cobalt Induced Chronic Toxic Encephalopathy Associated With Chromium Cobalt Hip Implants

Investigation of metal deposition in organs after joint replacement

Metallosis after metal-on-polyethylene total hip arthroplasty

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

The Bleeding Edge: behind the terrifying new Netflix documentary


Silicon Nitride Biomaterial, the Future

List of current/potential Si3N4 based products by market application:

List of 5 human studies utilizing Silicon Nitride Spinal Implants

Reciprocity between Si3N4 and living cells

Human osteoblasts grow transitional Si/N apatite in quickly osteointegrated Si3N4 cervical insert.

Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy

Silicon Nitride - Antimicrobial

AMEDICA ANNOUNCES FILING OF KEY PATENT APPLICATION RELATING TO THE ANTI-VIRAL EFFECT OF ITS SILICON NITRIDE - Study has yet to be published

Development of a SiYAlON glaze for improved osteoconductivity of implantable medical devices.

Quote:
Wear debris generated from SiNx coatings was round in shape, with a mean size of 40 nm, and ranged between 10 and 500 nm. Model particles, similar in size and shape as the wear debris, were soluble in simulated body fluid. The dissolution rate was higher than the expected rate of debris generation.


Dissolution behaviour of silicon nitride coatings for joint replacements

Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Bioceramics are Not Bioinert: The Role of Oxide and Non-Oxide Bioceramics on the Oxidation of UHMWPE Components in Artificial Joints


A pictures worth a thousand words


Reactions to Metals



The effects on bone cells of metal ions released from orthopaedic implants. A review


Reaction to Silica released/scavenged from Si3N4 implant surfaces



Silicon: The evolution of its use in biomaterials


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