SiNtx Technologies Inc (SINT)

[boston745]

Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.

https://www.nature.com/articles/srep39612

Roughening Titanium surface to increase its osteointegration has the unintended consequence of releasing increased amounts pf particles especially at the nano level. It seems different roughening methods yeild different results. Regardless roughening titanium surfaces does increase surface area, corrosion, and the potential for biofilm formation. This is also an issue for PEEK implants with roughened surfaces.

Bacterial specimens (Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa) adhered more homogeneously to sandblasted implants compared with other treatments. This suggests that sandblasting may place the implant at risk of infection and reduce the strength of interaction with the surrounding soft tissues. The ability to tune the adhesion of cells to additively manufactured Ti-6Al-4V implants using postprocessing methods was demonstrated. Because the degree of tissue integration required of implants is application specific, these methods may be useful to tailor osseointegration. However, surface competition between mammalian and bacterial cells remains a challenge.

https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00336?journalCode=abseba