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Sunday, 12/23/2018 11:37:54 AM

Sunday, December 23, 2018 11:37:54 AM

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They found that control individuals had very low levels of titanium in the blood whereas titanium concentrations were significantly higher for all the patients with implants. The sensitivity of the method was such that the researchers were also able to show significant differences in titanium levels for different types of bone fixation devices. The more invasive implants shed more metallic debris into the blood than the external, superficial designs. The work also identified how the titanium from the implants is transported in the bloodstream and potentially distributed and accumulated.


https://www.sciencedaily.com/releases/2011/07/110725101257.htm

A product must do more good than harm is a basic moto in healthcare. Im not sure I agree with this moto. However when a safer product is on market the safer product should be the obvious choice. Hopefully the FDA will help set new standards for patient safety so this choice becomes more obvious.


Titanium is a high-strength, highly corrosion resistant, low allergic potential metal commonly used in stainless steels
as a stabilising element. Pure titanium and the alloy titanium-aluminium-vanadium (Ti–6Al–4V) are among the most
widely used for biomedical applications42. Although regarded as a relatively inert metal, accumulation of titanium
particles and ions can induce osteolytic cytokines and inhibit osteoblast collagen expression
in vitro. Raised serum
levels of titanium have been found within synovial fluid, serum and urine of patients after total hip and knee
arthroplasty and following instrumented spinal arthrodesis


https://www.researchgate.net/publication/279995715_Modern_Metal_Implant_Toxicity_and_Anaesthesia

Si3N4 (silicic acid) can inhibit osteoclasts and "activate" osteoblast expression. It would make sense to use it in conjunction to offset negative reactions to titanium. While Si3N4 can counter some negative effects, it cannot do anything to counter titanium ions in blood. However a Si3N4 glaze can reduce the amount of corrosive titanium ions.
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