![](http://investorshub.advfn.com/images/default_ih_profile2_4848.jpg?cb=0)
Sunday, December 23, 2018 11:37:54 AM
They found that control individuals had very low levels of titanium in the blood whereas titanium concentrations were significantly higher for all the patients with implants. The sensitivity of the method was such that the researchers were also able to show significant differences in titanium levels for different types of bone fixation devices. The more invasive implants shed more metallic debris into the blood than the external, superficial designs. The work also identified how the titanium from the implants is transported in the bloodstream and potentially distributed and accumulated.
https://www.sciencedaily.com/releases/2011/07/110725101257.htm
A product must do more good than harm is a basic moto in healthcare. Im not sure I agree with this moto. However when a safer product is on market the safer product should be the obvious choice. Hopefully the FDA will help set new standards for patient safety so this choice becomes more obvious.
Titanium is a high-strength, highly corrosion resistant, low allergic potential metal commonly used in stainless steels
as a stabilising element. Pure titanium and the alloy titanium-aluminium-vanadium (Ti–6Al–4V) are among the most
widely used for biomedical applications42. Although regarded as a relatively inert metal, accumulation of titanium
particles and ions can induce osteolytic cytokines and inhibit osteoblast collagen expression in vitro. Raised serum
levels of titanium have been found within synovial fluid, serum and urine of patients after total hip and knee
arthroplasty and following instrumented spinal arthrodesis
https://www.researchgate.net/publication/279995715_Modern_Metal_Implant_Toxicity_and_Anaesthesia
Si3N4 (silicic acid) can inhibit osteoclasts and "activate" osteoblast expression. It would make sense to use it in conjunction to offset negative reactions to titanium. While Si3N4 can counter some negative effects, it cannot do anything to counter titanium ions in blood. However a Si3N4 glaze can reduce the amount of corrosive titanium ions.
Recent SINT News
- SINTX Technologies to Explore Strategic Opportunities • GlobeNewswire Inc. • 06/18/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/12/2024 01:05:12 PM
- SINTX Technologies Regains Compliance with Nasdaq Bid Price Requirement • GlobeNewswire Inc. • 06/12/2024 01:00:00 PM
- SINTX Technologies Receives Additional SBIR Contract for 3D Printing Technology • GlobeNewswire Inc. • 06/06/2024 01:00:00 PM
- SINTX TECHNOLOGIES SIGNS AGREEMENT TO ENTER KOREAN TECHNICAL CERAMICS SECTOR • GlobeNewswire Inc. • 05/29/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/23/2024 01:10:13 PM
- SINTX TECHNOLOGIES ANNOUNCES REVERSE STOCK SPLIT EFFECTIVE MAY 28, 2024 • GlobeNewswire Inc. • 05/23/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/15/2024 01:00:29 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/13/2024 09:20:34 PM
- SINTX AND PRODWAYS AGREE ON CERAMIC SLURRY SUPPLY AND 3D PRINTING AGREEMENT • GlobeNewswire Inc. • 04/29/2024 01:14:20 PM
- SINTX Technologies Announces Pricing of $1.5 Million Public Offering of Common Stock • GlobeNewswire Inc. • 04/03/2024 01:00:00 PM
- SINTX Technologies Announces Proposed Public Offering of Common Stock • GlobeNewswire Inc. • 03/29/2024 08:00:00 PM
- SINTX Technologies Announces Pricing of $1.3 Million Public Offering of Common Stock • GlobeNewswire Inc. • 03/25/2024 01:00:00 PM
- SINTX Technologies Announces Proposed Public Offering of Common Stock • GlobeNewswire Inc. • 03/22/2024 12:30:00 PM
- SINTX TECHNOLOGIES ENTERS INTO A SECOND LONG TERM SUPPLY AGREEMENT FOR THE AEROSPACE MARKET • GlobeNewswire Inc. • 02/21/2024 02:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/14/2024 02:00:28 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 01:12:54 AM
- Form SC 13G - Statement of acquisition of beneficial ownership by individuals • Edgar (US Regulatory) • 02/07/2024 09:42:32 PM
- SINTX Technologies Announces Closing of $4.0 Million Public Offering • GlobeNewswire Inc. • 02/02/2024 07:33:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/02/2024 11:30:20 AM
- Form 424B4 - Prospectus [Rule 424(b)(4)] • Edgar (US Regulatory) • 02/01/2024 10:14:28 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 02/01/2024 05:15:22 AM
- SINTX Technologies Announces Pricing of $4.0 Million Public Offering • GlobeNewswire Inc. • 01/31/2024 02:20:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/31/2024 11:05:14 AM
- SINTX SUBSIDIARY TECHNOLOGY ASSESSMENT & TRANSFER TO DEVELOP 3D PRINTING AND CMCs WITH DEVCOM-ARMY RESEARCH LABORATORY • GlobeNewswire Inc. • 01/30/2024 09:01:00 PM
Mass Megawatts Announces $220,500 Debt Cancellation Agreement to Improve Financing and Sales of a New Product to be Announced on July 11 • MMMW • Jun 28, 2024 7:30 AM
VAYK Exited Caribbean Investments for $320,000 Profit • VAYK • Jun 27, 2024 9:00 AM
North Bay Resources Announces Successful Flotation Cell Test at Bishop Gold Mill, Inyo County, California • NBRI • Jun 27, 2024 9:00 AM
Branded Legacy, Inc. and Hemp Emu Announce Strategic Partnership to Enhance CBD Product Manufacturing • BLEG • Jun 27, 2024 8:30 AM
POET Wins "Best Optical AI Solution" in 2024 AI Breakthrough Awards Program • POET • Jun 26, 2024 10:09 AM
HealthLynked Promotes Bill Crupi to Chief Operating Officer • HLYK • Jun 26, 2024 8:00 AM