SiNtx Technologies Inc (SINT)

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Titanium implants and silent inflammation in jawbone—a critical interplay of dissolved titanium particles and cytokines TNF-a and RANTES/CCL5 on overall health?

Such changes in areas of the JB may lead to hyperactivated signaling pathways of TNF-a induced R/C overexpression, and result in unrecognized sources of silent inflammation. This may contribute to disease patterns like rheumatic arthritis, multiple sclerosis, and other systemic-inflammatory diseases, which is widely discussed in scientific papers.

Conclusion
From a systemic perspective, we recommend that more attention be paid to the cytokine cross-talk that is provoked by dissolved Ti particles from DTI in medicine and dentistry.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107454/


Cross-sectional observational study exploring clinical risk of titanium allergy caused by dental implants

Conclusion
The prevalence of allergy-positive reactions to titanium allergens was lower than for other metal allergens. However, the results of the present study showed that titanium allergy exists. The findings of this study deny the null hypothesis that there is no titanium allergy in patients caused by dental implants. We suggest an examination of pre-implant patients who have a history of hypersensitivity reactions to metals.

https://www.sciencedirect.com/science/article/pii/S1883195818300148


The Effect of Titanium Implant on Oral Mucosal Epithelium

Cytomorphometric changes could be the earliest indicators of cellular alterations. There is progressive decrease in cellular diameter, increase in nuclear diameter in addition to increase in the formation of micronucleus and cluster sheet of epithelium in smears from all implant sites, as compared to normal adjacent teeth. This indicates that titanium implant could have a genotoxic effect on oral epithelium that causes cellular alteration.

http://www.oralhealth.ro/volumes/2017/volume-4/Paper988.pdf