SiNtx Technologies Inc (SINT)

[boston745]

Subsequently, a cross-sectional study was completed in which sterile or MRSA contaminated as-fired and machined Si3 N4 implants were inserted into the tibiae of 8-week old female Balb/c mice, and harvested on day 1, 3, 5, 7, 10, or 14 post-operatively for SEM. The findings demonstrated that the antimicrobial activity of the as-fired implants resulted from macrophage clearance of the bacteria during biofilm formation on day 1, followed by osseointegration through the apparent recruitment of mesenchymal stem cells on days 3-5, which differentiated into osteoblasts on days 7-14.

https://www.ncbi.nlm.nih.gov/m/pubmed/28865177/

PRESENTATION OF CASES: Presented here are two case studies of lumbar pyogenic discitis associated with Escherichia coli and Candida albicans infections. Both required single-level anterior discectomy followed by spinal fusion using an antimicrobial silicon nitride (Si3N4) spacer for stabilization without instrumentation. Localized antibiotics were used for only one of the patients. Follow-up CT and MRI scans showed that the infections had been resolved with no recurrence of symptoms.

https://www.ncbi.nlm.nih.gov/m/pubmed/29462728/


Live case study showing 2 cases where Si3N4 interbody devices were implanted with current infections. Pne patient was treated with antibiotics but in the end both patients walked away with no infections. Meaning Si3N4 killed both the bacteria & Candida.