SiNtx Technologies Inc (SINT)

[boston745]

The degree of peri-implant osteolysis induced by PEEK, CoCrMo, and HXLPE wear particles: a study based on a porous Ti6Al4V implant in a rabbit model

PEEK, CoCrMo, and HXLPE wear particles (approximately having the same size and doses) induce peri-implant osteolysis to a different degree: HXLPE particles induce peri-implant osteolysis to a mild degree, while PEEK and CoCrMo particles caused significant peri-implant osteolysis. In case of a porous implant, osteolysis occurred primarily in the peripheral region, rather than in the porous structures.

the average size of almost 90% of the wear particles was <?5.0 µm in diameter, and the particles were in similar shapes. Macrophages play a pivotal role in wear particle recognition and in the cascade of biological events leading to implant failure. The interaction of macrophages with wear debris triggers the release of pro-inflammatory factors, such as TNF-a and IL-1; pro-osteoclastic factors, such as RANKL (receptor activator of nuclear factor ?? ligand); and chemokines, such as MCP-1 (monocyte chemotactic protein-1), all being crucial to the recruitment, migration, differentiation, and ultimate activation of bone-resorbing osteoclasts

https://josr-online.biomedcentral.com/articles/10.1186/s13018-018-0736-y