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just an update regarding statins....im not 100% sure combo is the way to go with amarin
ill explain why...as most of you know im a pharmacist in england and recently i posted an article here about statins causing corneal problems. Speaking to an optician friend of mine he relayed similar worries about statin use with his parents and this got me worried. Now in the pharmacy the other day 2 patients came in with worries about using their statins long term and asking for a risk benefit analaysis and honestly i explained its relatively new however im pretty sure in the short term the cardioprotective benefits of statins will outweigh the risks
however i wonder that once more research is done into this will statins eventually come under a full review here in the uk and possibly abroad?
Statin eyesight loss - new article
http://www.express.co.uk/news/health/430792/Thousands-at-risk-of-losing-their-eyesight-by-taking-statin-pills
and of that 60% probably less then 50% is actually utilised following first pass metabolism :)
NEW SA ARTICLE EXPLAINS COURTS SHOCKING RULING
http://seekingalpha.com/article/1692562-amarin-and-teva-the-court-ruling-and-amarins-outlook?source=google_news
Evidently, as argued, back in 1987 (more than a year before the patent application), Norsk Hydro (Pronova's former self) sent samples of their drug to a few scientists to gauge interest in the product. One of these three scientists consumed the product and gave it to a few colleagues to try as well. TEVA artfully argues that this specific act constitutes "public use" and thus invalidates the patent. And the appellate court agreed! If someone could have made this same technical argument at any time in the last 15 years, there would have been abundant generic Lovaza and GSK/Pronova would never have had their $1 billion fish oil pill. When you read the case, it is quite amusing.
Ell Oh Ell teva Ell oh Ell
excuse me?? not used very much anymore??
im a backer of vascepa but the the percent of people allergic to penicillin is roughly 0.01% in Europe (according to my British National formulary) and about 6.5% of people allergic to penicillin are allergic to cephs
penicillin is used HUGELY infact i get about 30-40 prescriptions a day of penicillin, not just normal penicillin but Penicillin V, Flucloxacillin, amoxicillin, co-amoxiclav and the list goes on
penicillin is extremely useful and a necessary drug which i do believe vascepa could become one day
awesome over 5k! good goin amarin
i understand your point in relation to NCE
but researchers already do this...for instance if we look at isomerism...i cant remember the compound but i remember reading about a full compound which contained 2 stereoisomers (E/Z) and the presence of one isomer negated the positive activity of the other...so they had to somehow remove and utilise only a single isomer which in essence is exactly the same compound just a mirror reflection of the other
prevention of ischemia via angiogenesis would be great particularly in the reduce-it study where it would be a big help against preventing cv issues - a myocardial infarction can occur where you have cloggings in the coronary arteries which thereby prevent oxygen getting to the myocardium cells causing cell death > MI
However angiogenesis is one of the main methods by which cancerous cells proliferate - tumorous cells releaves VegF stimulating angiogenesis allowing oxygen for proliferation
so.....ye positive + negative i guess
statins + vascepa if i remember correctly have acted synergystically (therefore improving the positive effects of each other).
Statins are extremely good at lowering cholesterol and are extremely important medicines (having been proven to lower cv events)
no dr in there right mind will completely stop the use of statins without some sort of evidence of it being a hazard...
Plus they are extremely cheap and therefore the cost to healthcare is reduced..this would be severely increased if patients were all switched to dual doses of vascepa
DHA not EPA is responsible for prostate cancer by Dr Nina Bailey
http://igennus.com/dha-not-epa-responsible-for-omega-3-prostate-cancer-risk-by-dr-nina-bailey/
hah this is exactly what i said yesterday :) good find
as a pharmacist ive read many articles to how fish oils can help reduce the effects of diabetes as well as risk factors
if you are a type 1 diabetic then diabetic medicine are really no use to you
however for type 2 diabetics the effects on skeletal muscle which will allow better response to insulin and a reduction in resistance to insulin effects are surely possible with EPA
haha ye it was from yhm from the_girl_with_the_dragon_tattoo posted
thought id share it with the lovely folks here
ONDON (ShareCast) - AstraZeneca (NYSE: AZN - news) 's Chief Financial Officer (CFO) Simon Lowth is stepping down to join oil and gas firm BG Group (LSE: BG.L - news) .
He will leave the pharmaceutical giant in October, after reporting third quarter results, and will start as BG Group's new CFO the following month.
looks like the buying of epanova was too much for him :D
for those people who dont know why "p53-induction" is important
p53 is what we call "the guardian of the genome" its basically the most important gene in your cell in terms of protecting you against cancer. The p53 in basic terms will cause genomic changes in cells to lead to apoptosis (death of the cell) and therefore prevents the mutated cell becoming cancerous (a cell is not cancerous until it undergoes a certain number of mutations depending on the time of cancer)
if EPA can induce p53 induction in skin and can reduce the Uvradiation effects then once vascepa is licensed for off-label use forget lovaza Vascepa will rule
great read glad to know that someone can show up the FDA's incompetence for once
lol calling JZ questionably deceitful when everything he said hed do he did??? when he said hed explain all script and quaterly results recently he did,,,when he said hed apply for snda he did...when he said hed apply for anchor he did.....the only thing deceitful is the amount of hate that JZ gets largely due to the incompetence of the FDA in providing a NCE decision
considering the small sales for of about 250 sales reps, and all the negative media lately by bashers like AF and quoth the raven, when you compare script growth to other CV drugs it is going perfectly
Tier 2 is still kicking in and should be in alot more flow come july so we should see even high script growth around then (because health insurances will cover the costs)
Also combo data and a actual combo drug will bring in a whole new revenue stream, and of course anchor in December will increase the market size about 10 fold i guess
for 6/7/2013
weekly trx = 2879
nrx growth rate = 28.06%
refills growth - 2.7%
Great week folks :)
williams being a pharmacist i actually understood all of what you said (i studied isomeric translation when i was doing organic chemistry at uni)
but saying that your DD astounds me as well as your knowledge on these subjects
thanks again
LP
extremely important conference today for AMARIN in regards to information on Anchor as well as combo news will be listening intently
Here in the UK we have mixes already of some of these medicines
for instance Nuromol is available OTC (paracetamol aka tylenol + ibuprofen) which is great particularly for migraine i find it works
Morphine OTC??? ive never heard of that lol im not sure about America but here in london its a controlled drug and no way is it OTC, in low doses its available as a CD4 i believe (oramorph 10mg/5ml) however its still nowhere near available OTC, closest you can get OTC is dihydrodocodeine
Tylenol is liver toxic in very high doses (some patients take 6g a day for severe migraine (however its a unlicensed dose) but at regular doses its fine
in regards to cholesterol your obviously going to have to look at fitness and obesity (the more obese the higher the fat storage in the apoproteins, therefore the more free LDL/cholesterol there will be lying about in the blood which is not going to be able to be uptaken by the liver
metabolism would be more to do with glucose...obviously diabetics would have a lack of metabolism as there is a lack of insulin release/utility so lack of uptake of glucose into skeletal muscle
from what i know the person who posted these results, its his mother in law whos results they are and they are currently taking a few other medicines, however those medicines are long term and these results are from the addition of vascepa, so most of the effects seen should be due to vascepa, if not a synergistic effect of vascepa working with the other medicines (which would be great for combo news tbh)
htxxs://twixter.com/lingkui/status/337981392048766976
replace the x with https and twitter (if u didnt know)
these are results from a patient taking vascepa for only 45 days and they are unbelievable
cholesterol - 207 - 154
Trigs: 254 - 154
LDL: 111 - 79
That LDL reduction is more then what statins would have done and without the risk of rhabdomyolysis
id love to see anyone put a spin on that
tbh that is important
However the info i just reported is even more important JL particularly in recent times because of the uncertainty over ANCHOR
this info i believe will almost certainly make anchor accepted
Vascepa 4 g/day, when added to optimized statin therapy for 12 weeks, significantly reduced median particle concentrations of total very-low-density lipoprotein (VLDL) by 12.2%, total low-density lipoprotein (LDL) by 7.7%, and small LDL particles by 13.5%
Btw this was done in Anchor (high trig patients) not MARINE (Very high trig patients)
Basically anchor will go through, but AF wont lose money because hes not short
if your looking at it from an analytical point of view there has been a drop albeit not a huge one, however dont forget that its not only a drs decision to come off of a drug, in a pharmaceutical environment healthcare professionals are advised to act in what we call concordance with a patient, decisions are mutual unless money becomes a huge issue (say if a branded item becomes generic and its the same drug a dr wont be required to inform the patient they are giving them the generic). Therefore if a patient is working well on lovaza particularly elderly patients then the dr would first have to convince them of the benefits of vascepa before switching
possible lack of numbers today
as we know everyones looking towards the script numbers here and i generally get my script numbers from 2 guys on ST namely pharmaguy and AAreturn. AAreturn seems to have left ST and pharmaguy is away today so may mean no script numbers...hopefully someone else gets it....otherwise well have to wait till monday/tuesday before we hear from AF with his IMS numbers
brilliant find kaylawa - shows intent from amarin to pursure anchor asap and also making AF's utterly laughable predictions of anchor denial less and less likely
lol this is the funniest load of rubbish ive read in years
"special fish oil" is on prescription, so tell me should so called "copy-cat drugs" for instance ramipril enalapril captopril be removed from the market too? because all they are are basically exactly the same drug with a minor modification which in turn increases a price by ridiculous amounts for possibly no change in efficacy?
you dont get that medicines no matter how small changes, no matter what the product, if it can cause a change in someones life and can improve their quality of life then its worth it and vascepa is definitely worth it no matter what the drug is at its core
IMS # = 2780, which is a 14.3% increase (again by pharmaguy) - numbers seem to be very different this week
updated script values
for week ending 5/3, TRx's = 2989 (as said by pharmaguy on ST)
h**p://w*w.fool.com/investing/general/2013/05/11/some-fish-oil-doesnt-help-some-patients-in-some-co.aspx
absolutely top quality article released by the fool (im sure some of you guys have read it) but it totally summed up my already known thoughts on that useless trial conducted in Italy
for one we over here in the UK use a book in pharmacy known as the BNF (also known as the british national formulary) it contains drug indications, side effects, dose regimens, safety information and interactions as well as recommendations from NICE (which determine first/second line treatments depending on what we call the cost:benefit ratio - aka is a drug worth the potential benefits)
anyway the main points that they derive from this study is firstly the awful way in which the patients were selected, infact some patients final outcome was so much higher then expected they had to change the endpoints midway in the trial
Also the trial was done in Italy whose dietary consumption, standard BMI and many other factors will hugely vary as opposed to Americans which is important because thats where Vascepa is targetting,
and finally the amount recommended in the BNF for Omacor (aka lovaza) is 4g daily, this study used "omega-3" fish oils at a dose of 1g daily - aka far below a therapeutic dose
therefore this study is useless
just my guess but "omega 3" fatty acids doesnt indicate use of EPA or DHA these are just any fatty acids with the structure fitting "omega 3" - and from what i know they have to form EPA and DHA through a form of reduction? or something like that
therefore its not exactly a test of vascepa whatsover
my thoughts exactly JL
also other cascades would be the kinase cascades which i did my thesis on - involving MAPK/ERK etc and involved in physiological metabolism etc
this doesnt take nanoseconds either, for instance when we look at things like apoptosis the decision for a cell to go into apoptosis will take at least a few seconds...which for the sake of argument would be 2x10^9 nanoseconds
im not a doctor but im a pharmacist and from what i know for severe back/nerve pain they can give a TCA like amitriptyline or Pregabalin (anti-epileptics work great in this instance)
also NSAIDs like ibuprofen 600mg three times daily will help
im not sure about vascepa...id consider these instances before epidurals
script numbers 2824 giving a 16.9% increase
great numbers for the week keep it up amarin
thanks for that very good note from aegis
thats a gd point, but i still think that script numbers will bring a bit of confidence back to investors and will also give BPs more of a reason to buy out amarin
so anyone who reads Stock twits, ihub and yahoo message boards wd be familiar with the script number convos going about
after the disappointing stock numbers last week, one of the yahoo msg board posters said he works in that kind of field and said he felt it was a delayed response to the tier changes as well as sNDA submission and a few other factors
i think hes right, not to forget that Lovaza also had a month where script numbers decreased during its launch, I do think this week scripts shud be up (i hope) and will keep rising specially since lovaza 3 month refills shud be coming to an end. Also i have a reservedness about listening to what IMS says but right now since amarin is not revealing any data i dont think we have much else to go on