Biotech Values

[DewDiligence]

IDIX ReadMeFirst

[Updated for latest Sustiva and Baraclude sales.]


What is IDIX’s business all about?
Business description from latest 10K filing
#msg-26915852 IDIX’s drug portfolio
#msg-25899731 What’s not to like?
#msg-26915744 Addressable markets for antiviral drugs
#msg-29979703 Notes from Needham webcast (6/12/08)


Valuation and finances
#msg-28886425 1Q08 financial results
#msg-25870940 IDIX vs VRUS (based on 1/9/08 valuations)
#msg-30937598 Recent biotech buyouts with a large premium


Upcoming events
#msg-29019233 2008-2009 clinical goals


Officers, directors, and major shareholders
#msg-28869752 Composition of Board of Directors
Capsule résumés of executive officers (click on a name)
#msg-29876323 Largest shareholders
#msg-29157548 Standstill agreement with NVS has expired
#msg-27682782 Insider Transactions During Past 24 Months
#msg-29876308 Current insider shareholdings


HIV program: economic rationale
#msg-28959639 Musings on size of an HIV partnership
#msg-29985807 When and how NVS may get involved
#msg-26915744 HIV addressable market
#msg-26220473 HIV market in Europe’s Big-5 countries
#msg-26915314 IDX899 seeks to supersede Sustiva
#msg-27344078 Economics of the first-line setting
#msg-30944437 Sustiva sells more than $1.1B/yr
#msg-30787392 Market size and share info from GILD CC
#msg-24139072 Increased HIV screening will expand market


HIV program: clinical rationale
#msg-29959114 7-day monotherapy data (PR)
#msg-29979516 7-day monotherapy data (chart)
#msg-26915885 Flowchart for IDX899 development
#msg-29985830 Design of a late-stage HIV trial
#msg-26800695 Why is IDIX testing lower doses?
#msg-24329960 IDX899 has no cross-resistance to Sustiva


HIV program: competition
#msg-24673329 HIV competitive landscape
#msg-28555106 Colossal importance of qD dosing
#msg-26126733 FDA approves Intelence (TMC125)
#msg-26643515 Intelence 48w data in NNRTI-refractory HIV
#msg-30789106 TMC278 enters phase-3
#msg-26610262 Pfizer’s UK 453,061
#msg-30255144 Ardea’s RDEA806
#msg-23282517 Miscellaneous early-stage NNRTI’s


HCV program
#msg-28715477 IDX184 data from EASL
#msg-26915921 How is IDX184 better than NM283?
#msg-26915744 HCV addressable market
#msg-29018192 Factoids re US patient pool
#msg-30190435 Devastating risk of undertreating HCV
#msg-29496053 HCV competitive landscape for new agents
#msg-28863807 Telaprevir vs Boceprevir
#msg-29196186 Musings on future combination therapy


HBV program: economics
#msg-23242360 Restructuring of Tyzeka relationship with NVS
#msg-24405569 Twelve different royalty tiers
#msg-23249593 Conjecture on the royalty rates
#msg-26915744 HBV addressable market
#msg-23785846 Status of European launch
#msg-23434932 Treating asymptomatic e- patients will boost market
#msg-11099728 Asian immigrants are largely untreated
#msg-21358606 Why a slow sales ramp for new HBV drugs?
#msg-21388028 Bearish opinion by ‘gofishmarko’
#msg-30142390 Tyzeka US scripts


HBV program: clinical data
#msg-14377860 Two-year data from GLOBE trial
#msg-22771520 Tyzeka studies in progress
#msg-12271882 Tyzeka resistance data
#msg-14404551 Tyzeka’s efficacy comparable to Baraclude’s (1)
#msg-18389527 Tyzeka’s efficacy comparable to Baraclude’s (2)
http://www.fda.gov/cder/foi/label/2006/022011lbl.pdf FDA product label


HBV program: competition
#msg-21652956 Prices of HBV drugs
Baraclude:
#msg-30936931 Current Baraclude sales
#msg-30936953 Baraclude sales ramp 2005-present
#msg-22555240 Baraclude studies in progress
#msg-21652925 Baraclude’s black-box warning for HIV/HBV co-infection
#msg-21678801 Tyzeka’s edge in pre-menopausal women
#msg-23241377 Baraclude resistance data
Viread/Truvada/Hepsera:
#msg-27780508 Viread approved for HBV in EU
#msg-21460468 GILD to cease promotion of Hepsera
#msg-24255644 Phase-3 Viread data
#msg-22555241 Viread/Truvada studies in progress
Clevudine:
#msg-23309283 Global phase-3 program
#msg-28925042 Musings on sustained virologic response (SVR)
#msg-14328142 Clinical results from Korea
#msg-20218516 Clevudine, Tyzeka are structurally similar


Reference links
http://www.idenix.com/hiv/about
http://www.aidsmeds.com/list.shtml
http://www.idenix.com/hepc/about
http://www.hcvdrugs.com/
http://www.hivandhepatitis.com
http://www.cdc.gov/ncidod/diseases/hepatitis/b/fact.htm
http://www.who.int/mediacentre/factsheets/fs204/en
http://www.idenix.com/about/media/Glossary_of_terms.pdf