Biotech Values

[biomsmdawg]

When you compare Entecavir/Telbivudine 1 year data, they look pretty close. All are nucleoside naive pts.

From the pIII Telbivudine trial (GLOBE) @ 52 wks:
VL redn (HbeAg+): T-6.4 log vs Lamiv -5.5 log
VL redn (HbeAg-): T-5.2 log vs Lamiv -4.4 log
VL < 400(HBeAg+): T 60% vs L 40%
VL < 400(HBeAg-): T 88% vs L 71%
ALT normalization (HBeAg+): T 77 vs L 75%
ALT normalization (HBeAg-): T 74 vs L 79%

From the pIII Entecavir trials (AI463-022,AI463-027) @ 48 wks:
VL redn (HBeAg+): E -6.98 log, Lamiv -5.46 log
VL redn (HbeAg-): T-5.2 log vs Lamiv -4.4 log
VL < 400(HBeAg+): E 67% vs L 36%
VL < 400(HbeAg-): E 91% vs L 73%
ALT normalization (HBeAg+): E 78% vs L 70%
ALT normalization (HBeAg-): T 89% vs L 84%

These numbers are from my db, but I believe they're accurate. Based on the above, considering the similar responses to Lamivudine, you'd need to run a very large head to head trial to see any distinction at one year.