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Compiled:GENETIC ISSUES - SEX and more 07/12/19

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Anavex Life Sciences Announces Achievement of Enrollment Target for the ANAVEX®2-73 (blarcamesine) Phase 2 Parkinson’s Dis... GlobeNewswire Inc. - 1/27/2020 7:00:10 AM
Anavex Life Sciences Issued New U.S. Patent for ANAVEX®2-73 Treatment of Neurodevelopmental Disorders including Rett Syndrom... GlobeNewswire Inc. - 1/8/2020 7:00:10 AM
Anavex Life Sciences Reports Fiscal Year 2019 Financial Results And Provides Clinical Study Updates GlobeNewswire Inc. - 12/16/2019 7:00:10 AM
Anavex Life Sciences to Announce Fiscal 2019 Year End Financial Results on Monday December 16, 2019 GlobeNewswire Inc. - 12/10/2019 7:00:10 AM
Citation Growth Corp. (OTCQX: CGOTF) Weathering the Cannabis Downturn InvestorsHub NewsWire - 12/9/2019 7:23:11 AM
Anavex Life Sciences Presents ANAVEX®2-73 (blarcamesine) Data at 12th Clinical Trials on Alzheimer's Disease (CTAD) 2019 Con... GlobeNewswire Inc. - 12/4/2019 7:00:10 AM
Anavex Life Sciences Receives Rare Pediatric Disease Designation from FDA for ANAVEX®2-73 (blarcamesine) for the Treatment o... GlobeNewswire Inc. - 11/14/2019 7:00:00 AM
Anavex Life Sciences Announces Publication of Foundational Data for ANAVEX®2-73 (blarcamesine) in Rett Syndrome GlobeNewswire Inc. - 11/6/2019 7:00:00 AM
Anavex Life Sciences Announces ATTENTION-AD ANAVEX®2-73 Extension Clinical Study in Early Alzheimer’s Disease GlobeNewswire Inc. - 10/9/2019 7:00:00 AM
Anavex Life Sciences Issued New U.S. Patent for Composition of Matter Covering ANAVEX®2-73 for the Treatment of Alzheimer’... GlobeNewswire Inc. - 10/2/2019 7:00:00 AM
Anavex Life Sciences Presented at the 6th Annual European Rett Syndrome Conference Preliminary Clinical Efficacy Data from th... GlobeNewswire Inc. - 9/27/2019 3:00:00 AM
Anavex Life Sciences to Present at the 2019 Cantor Fitzgerald Global Healthcare Conference GlobeNewswire Inc. - 9/26/2019 7:00:00 AM
Notice of Effectiveness (effect) Edgar (US Regulatory) - 9/23/2019 6:35:19 AM
Anavex Life Sciences to Present at the Ladenburg Thalmann 2019 Healthcare Conference GlobeNewswire Inc. - 9/18/2019 7:00:00 AM
Post-effective Amendment to Registration Statement (pos Am) Edgar (US Regulatory) - 9/17/2019 5:16:10 PM
CLS Holdings (CLSH) $1.15 Price Target - MASS Approval for Recreational License InvestorsHub NewsWire - 9/17/2019 7:17:00 AM
Withdrawal of Registration Statement (ammendment) (aw) Edgar (US Regulatory) - 9/16/2019 4:17:42 PM
Anavex Life Sciences Announces Preliminary Clinical Efficacy Data of its U.S. Phase 2 Clinical Trial of ANAVEX®2-73 in Patie... GlobeNewswire Inc. - 9/16/2019 7:00:00 AM
Current Report Filing (8-k) Edgar (US Regulatory) - 9/13/2019 5:11:08 PM
Prospectus Filed Pursuant to Rule 424(b)(5) (424b5) Edgar (US Regulatory) - 9/13/2019 5:07:24 PM
Securities Registration Statement (simplified Form) (s-3/a) Edgar (US Regulatory) - 9/13/2019 5:02:44 PM
Anavex Life Sciences to Present at the Janney Healthcare Conference 2019 GlobeNewswire Inc. - 9/5/2019 7:00:00 AM
Anavex Life Sciences Announces Initiation of the EXCELLENCE ANAVEX®2-73-RS-003 Clinical Study in Pediatric Patients with Ret... GlobeNewswire Inc. - 9/4/2019 7:00:00 AM
Quarterly Report (10-q) Edgar (US Regulatory) - 8/7/2019 4:07:28 PM
Anavex Life Sciences Reports Fiscal 2019 Third Quarter Financial Results And Provides Clinical Study Updates GlobeNewswire Inc. - 8/7/2019 7:00:00 AM
XenaLives Member Level  Friday, 07/12/19 02:40:07 PM
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Post # of 232801 
Compiled:GENETIC ISSUES - SEX and more 07/12/19

Genomic and epigenomic biomarkers are the key to precision medicine.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149763601
____________________________________________________________________________________________
GENETICS INFORMING TRIALS AND PRACTICE:

PHARMACOLOGY + GENOMIC = PHARMACOGENOMICS


The ideal pharmacogenomics test will be able to determine:

• Potential for a medication to be effective – for this person
• The best dose of a medication – for this person
• Avoid risk of serious side effects - for this person

https://www.anavex.com/wp-content/uploads/2019/04/Anavex-Presentation-April-2019.pdf
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149157245
- above is cut and pasted from a georgejjl post


Evolution of clinical trials in multiple sclerosis
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148140606

FDA is now testing Real-World Evidence and comparing to randomized controlled trials:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148145719

2018 Conference presentations on pharmacogenomics epidemiology:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148156807

____________________________________________________________________________________________
GENETICS:

CRISPER discovery of likely MOA for 2-73:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144274561

DNA and BIOMARKERS (From Mikesc)
https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-016-0284-4

Apoe4 and Alzheimer's
https://medicalxpress.com/news/2016-08-scientists-reveal-people-apoe4-gene.html
https://www.snpedia.com/index.php/APOE

Anavex 2-73 Won’t Be “Gene Therapy;” Better (from falconer66a)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147087396

Health Conditions Related to Genetic Changes
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636445

____________________________________________________________________________________________
EPIGENETICS:

Epigenetics and Autoimmune disease:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149317433
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149317468

Anavex sigma-1 receptor agonists may treat epigenetic damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147090448

Mitochondrial dysfunction, disease pathology and epigenetics:
https://learn.genetics.utah.edu/content/epigenetics/inheritance/

Epigenetics and Rett Syndrome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147643763

Epigenetic change:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148594441
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147910951
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147927639
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147906404
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147900786
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142496828

Why SSRI's are a FAIL:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039

Fluoride, Epigenetic change and Alzheimer's
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147640105

Importance of the COMT gene:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147635325
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636055

Childhood abuse, the COMT gene and anger:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039

____________________________________________________________________________________________
SEX DIFFERENCES:

Men, Women, Alzheimer's and gene expression - (from raja45185)
https://www.asianage.com/life/health/060519/new-drugs-to-target-alzheimers.html

Do women have "younger" brains? (from baltimorebullet)
https://www.mprnews.org/story/2019/02/05/npr-scans-show-womens-brains-remain-youthful-as-male-brains-wind-down

Women and Alzheimers:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934418/
https://www.alz.co.uk/sites/default/files/pdfs/Women-and-Dementia.pdf

Sex hormones and womens' mental health:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148139054

Genetic Mutations & Estrogen Metabolism (COMT)
https://peacewithendo.com/2015/04/genetic-mutations-estrogen-dominance.html

The elegance of the progesterone theory:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147783390

The benefits of HRT, if initiated early enough in healthy women, are far greater than the potential adverse effects.
https://www.mja.com.au/journal/2009/190/6/benefits-oestrogen-following-menopause-why-hormone-replacement-therapy-should-be

More on hormone replacement history:
https://www.forbes.com/sites/forbesbooksauthors/2017/04/16/the-long-and-misunderstood-history-of-hormone-replacement-therapy/#47999b23667c

Progesterone:
https://investorshub.advfn.com/boards/read_msgs.aspx?board_id=11474&NextStart=175189&BatchSize=20

Women and Benzodiazepiens:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145578631

Women and choline:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146528112
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146530875

MS and gender bias
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145789105





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