Compiled:GENETIC ISSUES - SEX and more 07/12/19 Genomic and epigenomic biomarkers are the key to precision medicine. https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149763601 ____________________________________________________________________________________________ GENETICS INFORMING TRIALS AND PRACTICE: PHARMACOLOGY + GENOMIC = PHARMACOGENOMICS The ideal pharmacogenomics test will be able to determine: • Potential for a medication to be effective – for this person • The best dose of a medication – for this person • Avoid risk of serious side effects - for this person https://www.anavex.com/wp-content/uploads/2019/04/Anavex-Presentation-April-2019.pdf https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149157245 - above is cut and pasted from a georgejjl post Evolution of clinical trials in multiple sclerosis https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148140606 FDA is now testing Real-World Evidence and comparing to randomized controlled trials: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148145719 2018 Conference presentations on pharmacogenomics epidemiology: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148156807 ____________________________________________________________________________________________ GENETICS: CRISPER discovery of likely MOA for 2-73: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144274561 DNA and BIOMARKERS (From Mikesc) https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-016-0284-4 Apoe4 and Alzheimer's https://medicalxpress.com/news/2016-08-scientists-reveal-people-apoe4-gene.html https://www.snpedia.com/index.php/APOE Anavex 2-73 Won’t Be “Gene Therapy;” Better (from falconer66a) https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147087396 Health Conditions Related to Genetic Changes https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636445 ____________________________________________________________________________________________ EPIGENETICS: Epigenetics and Autoimmune disease: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149317433 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149317468 Anavex sigma-1 receptor agonists may treat epigenetic damage: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147090448 Mitochondrial dysfunction, disease pathology and epigenetics: https://learn.genetics.utah.edu/content/epigenetics/inheritance/ Epigenetics and Rett Syndrome: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147643763 Epigenetic change: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148594441 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147910951 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147927639 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147906404 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147900786 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142496828 Why SSRI's are a FAIL: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039 Fluoride, Epigenetic change and Alzheimer's https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147640105 Importance of the COMT gene: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147635325 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147636055 Childhood abuse, the COMT gene and anger: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147637039 ____________________________________________________________________________________________ SEX DIFFERENCES: Men, Women, Alzheimer's and gene expression - (from raja45185) https://www.asianage.com/life/health/060519/new-drugs-to-target-alzheimers.html Do women have "younger" brains? (from baltimorebullet) https://www.mprnews.org/story/2019/02/05/npr-scans-show-womens-brains-remain-youthful-as-male-brains-wind-down Women and Alzheimers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934418/ https://www.alz.co.uk/sites/default/files/pdfs/Women-and-Dementia.pdf Sex hormones and womens' mental health: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148139054 Genetic Mutations & Estrogen Metabolism (COMT) https://peacewithendo.com/2015/04/genetic-mutations-estrogen-dominance.html The elegance of the progesterone theory: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147783390 The benefits of HRT, if initiated early enough in healthy women, are far greater than the potential adverse effects. https://www.mja.com.au/journal/2009/190/6/benefits-oestrogen-following-menopause-why-hormone-replacement-therapy-should-be More on hormone replacement history: https://www.forbes.com/sites/forbesbooksauthors/2017/04/16/the-long-and-misunderstood-history-of-hormone-replacement-therapy/#47999b23667c Progesterone: https://investorshub.advfn.com/boards/read_msgs.aspx?board_id=11474&NextStart=175189&BatchSize=20 Women and Benzodiazepiens: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145578631 Women and choline: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146528112 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146530875 MS and gender bias https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145789105
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