Replies to post #12768 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

Auxiliary Reference List of Antithrombin Papers

[Added Cuomo abstract.]


Cardiovascular/stroke
#msg-31305782 AT reduces ischemic volume (Cuomo)
#msg-30287557 Elevation of AT in arteriosclerosis
#msg-29955598 Coronary revascularization
#msg-27074358 Acquired AT deficiency increases risk
#msg-25952778 AT treatment after cardiac surgery
#msg-24268577 Stroke (preclinical)
#msg-13345041 Thrombin increases cardiomyocyte death


DIC / Sepsis
(A separate post accessible from the ‘ReadMeFirst’
contains the primary scientific support for ATryn in
DIC/sepsis, including analysis of the KyberSept study.)
#msg-29423778 AT MoA in sepsis (full paper)
#msg-27419164 How the ISTH DIC score is calculated
#msg-27215812 Scripps paper on sepsis MoA
#msg-29874443 AT works best in medium-risk patients
#msg-26018349 Animal model of gram-positive septicemia
#msg-25907502 Pct of sepsis patients with DIC
#msg-25907331 Hemostatic changes
#msg-25511473 Ditto
#msg-25480768 Anti-inflammatory MoA
#msg-24523875 AT experience in ICU
#msg-24518865 SIRS
#msg-23829730 Animal model
#msg-14277430 Thrombomodulin in DIC
#msg-29874324 Meta-analysis
#msg-13512229 Meta-analysis
#msg-13150691 Animal model
#msg-13102302 Review re AT and APC
#msg-12975208 AT level has predictive value
#msg-12960346 Coagulation vs inflammation pathways
#msg-12743571 Animal model
#msg-12681781 ISTH score for DIC
#msg-11211288 Animal model of AT with tPA
#msg-10232620 Hemostatic changes
#msg-8452794 Reduction of D-dimer levels
#msg-7268415 ATryn itself effective in small study


Adverse outcomes during pregnancy
#msg-26421404 Severe pre-eclampsia
#msg-25630072 DVT
#msg-22037334
#msg-9327646
#msg-8988372
#msg-8256536
#msg-7834418
#msg-7050226


Hereditary deficiency
#msg-25630072 DVT rate (acute)
#msg-24140012 Lovenox doesn’t work in HD
#msg-6794514 DVT rate (chronic)


Cancer
#msg-18991235 Pediatric ALL
#msg-12476761 Coagulation in cancer
#msg-12181584 Acute lymphoblastic leukemia
#msg-11804544 Use of anti-thrombotics in cancer
#msg-9460320 Liver mets in colon cancer
AT fragment in lung-cancer model


Chemistry and pharmacokinetics
#msg-13173404 Covalent linkage between AT and heparin
#msg-12100172 PK of AT from CHO cells
#msg-11801772 PK of ATryn vs plasma AT
#msg-30027881 Ditto
#msg-7669971 AT glycosylation
#msg-6995560 AT glycosylation


Miscellaneous
#msg-30028400 Human nephrotic syndrome
#msg-28267133 VOD
#msg-27074306 FVIII deficiency
#msg-26018345 Burns
#msg-25590840 Increasing AT yield from CHO cells
#msg-25481215 Acute lung injury (preclinical)
#msg-25291011 Ditto
#msg-20210837 ARDS
#msg-15039853 Burns
#msg-14277297 Polymicrobial peritonitis
#msg-14199820 Platelet adhesion
#msg-13292817 Pediatric ECMO
#msg-12714409 Retinal vein occlusion
#msg-11611213 VOD combo treatment with defibrotide
#msg-11609770 SPK transplantation
#msg-10969504 Recurrent thromboembolism risk
#msg-10321740 Aneurysm surgery