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DewDiligence

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DewDiligence

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Re: DewDiligence post# 6244

Friday, 12/21/2007 9:06:18 AM

Friday, December 21, 2007 9:06:18 AM

Post# of 19309
Here’s another preclinical study of AT in lung injury:

http://tinyurl.com/2ef8vn

>>
Antithrombin Inhibits Bronchoalveolar Activation of Coagulation and Limits Lung Injury During Streptococcus Pneumonia In Rats

Crit Care Med. 2007 Oct 23.

Choi G, Hofstra JJ, Roelofs JJ, Rijneveld AW, Bresser P, van der Zee JS, Florquin S, van der Poll T, Levi M, Schultz MJ.

Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

OBJECTIVE: Alveolar fibrin deposition is a hallmark of pneumonia. It has been proposed that natural inhibitors of coagulation, including activated protein C, antithrombin, and tissue factor pathway inhibitor, exert lung-protective effects via anticoagulant and possibly anti-inflammatory pathways. We investigated the role of these natural anticoagulants in Streptococcus pneumoniae pneumonia.

SUBJECTS: Total of 98 male Sprague-Dawley rats.

INTERVENTIONS: Rats were challenged intratracheally with S. pneumoniae (serotype 3, 10 colony forming units), inducing pneumonia. Rats were randomized to intravenous treatment with normal saline, activated protein C, antithrombin, tissue factor pathway inhibitor, heparin, or tissue-type plasminogen activator.

MEASUREMENTS AND MAIN RESULTS: Rats infected with S. pneumoniae had increased thrombin-antithrombin complexes in bronchoalveolar lavage fluid, with decreased levels of antithrombin activity and fibrin degradation products. Administration of activated protein C, antithrombin, and tissue factor pathway inhibitor significantly limited these procoagulant changes. Furthermore, antithrombin treatment resulted in less bacterial outgrowth of S. pneumoniae and less histopathologic damage in lungs.

CONCLUSIONS: Anticoagulant treatment attenuates pulmonary coagulopathy during S. pneumoniae pneumonia. Antithrombin seems to exert significant lung-protective effects in pneumococcal pneumonia in rats.
<<

“The efficient-market hypothesis may be
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