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Post# of 253567
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DewDiligence

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DewDiligence

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Sunday, 06/26/2005 3:57:15 PM

Sunday, June 26, 2005 3:57:15 PM

Post# of 253567
GTCB: New article discusses long-term
DVT recurrence rates for individuals with
antithrombin HD and related disorders:

[The DVT recurrence rates cited in this abstract are long-term “background” rates for individuals who did not undergo medical procedures. As stated in #msg-6652758, the acute DVT rate for individuals with antithrombin deficiency who undergo elective surgery or Caesarian childbirth without antithrombin augmentation (ATryn) is as high as 30%.]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_...

>>
Arterioscler Thromb Vasc Biol. 2005 Jun 23

Recurrence Rate After a First Venous Thrombosis in Patients With Familial Thrombophilia.

Vossen CY, Walker ID, Svensson P, Souto JC, Scharrer I, Preston FE, Palareti G, Pabinger I, van der Meer FJ, Makris M, Fontcuberta J, Conard J, Rosendaal FR.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; the Department of Haematology, Glasgow Royal Infirmary, Glasgow, UK; the Department for Coagulation Disorders, University Hospital, Malmo, Sweden; the Department of Haematology J.C.S., J.F.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; the Department of Internal Medicine, University Hospital, Frankfurt/Main, Germany; the Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK; the Department of Angiology and Blood Coagulation, University Hospital S. Orsola, Bologna, Italy; the Department of Haematology and Haemostaseology, University Hospital Vienna, Vienna, Austria; the Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands; and the Department of Biological Haematology, Hotel-Dieu Hospital, Paris, France.

OBJECTIVE: Few comprehensive data are available on the recurrence rate of venous thrombosis in carriers of thrombophilic defects from thrombophilic families. We prospectively determined the recurrence rate after a first venous thrombotic event in patients with familial thrombophilia attributable to factor V Leiden or deficiencies of protein C, S, or antithrombin.

METHODS AND RESULTS: Data were gathered during follow-up on the occurrence of risk situations, anticoagulation treatment, and events (eg, venous thrombosis, hemorrhage). Over a mean follow-up period of 5.6 years, 44 of the 180 patients with familial thrombophilia who did not use long-term anticoagulation experienced a recurrent venous thromboembolic event (5.0%/year; 95% CI 3.6 to 6.7) compared with 7 of the 124 patients on long-term anticoagulation (1.1%/year; 95% CI 0.4 to 2.2). Spontaneous events occurred less often in patients on long-term anticoagulation (57%) than in patients without long-term anticoagulation (75%). The highest recurrence rate was found among men with a deficiency in natural anticoagulants or multiple defects and women with antithrombin deficiency. Although long-term anticoagulation treatment decreased the incidence of recurrent events by 80%, it also resulted in a risk of major hemorrhage of 0.8% per year.

CONCLUSIONS: Extra care after a first event is required for men with a deficiency in natural anticoagulants or multiple defects and women with antithrombin deficiency.

PMID: 15976329 [PubMed - as supplied by publisher]
<<

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