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Post# of 19309
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DewDiligence

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DewDiligence

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Re: None

Monday, 08/28/2006 1:24:56 PM

Monday, August 28, 2006 1:24:56 PM

Post# of 19309
One reason antithrombin has been used
to treat sepsis is that sepsis has both an
inflammatory and a coagulative component.
This abstract reports that the pathways
inherent in these two disease components
do not overlap.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&l...

>>
No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats.

Crit Care Med. 2006 Aug 22.

Ontachi Y, Asakura H, Takahashi Y, Hayashi T, Arahata M, Kadohira Y, Maekawa M, Omote M, Yoshida T, Yamazaki M, Morishita E, Miyamoto KI, Nakao S.

Department of Internal Medicine (III) (YO, HA, TH, MA, YK, MM, MY, EM, SN), Hospital Pharmacy (YT, KM), and Department of Laboratory Medicine (MO, TY), Kanazawa University School of Medicine, Japan.

OBJECTIVE: Previous reports have suggested an interplay between the pathways mediating coagulation and inflammation in endotoxemia and sepsis. The present study was designed to examine whether cross-signaling between the pathways mediating coagulation and inflammation occurs, as suggested by the pattern of cytokine production observed following tissue-factor (TF)-induced disseminated intravascular coagulation (DIC).

INTERVENTIONS: Male Wistar rats aged 6-7 wks and weighing 160-170 g were administered TF (3.75 units/kg every 4 hrs), TF, and tranexamic acid (TA; 50 mg/kg every 4.5 hrs) or lipopolysaccharide (30 mg/kg every 4 hrs) via the tail vein, and blood was sampled at 0, 4, 8 and 12 hrs.

MEASUREMENTS AND MAIN RESULTS: Subsequent alterations in thrombin-antithrombin complex and fibrinogen levels, as well as platelet counts, indicated that the severity of both types of experimental DIC (TF-induced and lipopolysaccharide-induced) was similar with respect to hemostatic activation and development of consumption coagulopathy. In lipopolysaccharide-induced DIC, a sharp increase in plasma tumor necrosis factor levels was observed at 4 hrs, after which a sharp decline was noted. Plasma levels of interleukin-6 were markedly increased at 4 hrs, after which a sustained elevation was observed for the duration of the experimental period (tumor necrosis factor, 1270 +/- 280, 180 +/- 40, and 120 +/- 30 pg/mL at 4, 8 and 12 hrs, respectively; interleukin-6, 5810 +/- 1320, 4850 +/- 730, and 5230 +/- 1280 pg/mL at 4, 8 and 12 hrs, respectively). On the other hand, tumor necrosis factor and interleukin-6 were not detected following TF-induced DIC (0 +/- 0 at 4, 8, and 12 hrs for both tumor necrosis factor and interleukin-6). In the TF+TA group, significant increases in tumor necrosis factor and interleukin-6 were observed, compared with the TF group.

CONCLUSIONS: There is no overt interplay between the pathways mediating coagulation and inflammation in TF-induced DIC, as observed in lipopolysaccharide-induced DIC.
<<

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
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