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[DewDiligence]

Two Successful Pregnancies following
Eight Miscarriages in a Patient with
Antithrombin Deficiency:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_...

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Gynecol Obstet Invest. 2005 Oct 21;61(2):111-114 [Epub ahead of print]

Szilagyi A, Nagy A, Tamas P, Vizer M, Szabo I, Losonczy H.

Department of Obstetrics and Gynecology, University of Pecs, Pecs, Hungary.

Inherited thrombophilias are associated with an increased risk of maternal thromboembolism and certain adverse pregnancy outcomes, including second- and third-trimester fetal loss, placental abruption, severe intrauterine growth restriction, and early-onset, severe preeclampsia. Pregnant patients with severe thrombophilias, especially antithrombinopathies are at very high risk for both thromboembolism and adverse pregnancy outcomes.

A case of a patient with antithrombin deficiency is reported, who had two successful pregnancies after eight miscarriages. Our case shows that a combined treatment with antithrombin substitution and a prophylactic, body-weight-adjusted dose of low-molecular-weight heparin may be successful in preventing pregnancy loss and thromboembolism in antithrombin deficiency during pregnancy, although other complications, such as preeclampsia and intrauterine growth restriction cannot always be prevented.
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