Replies to post #5876 on Amarin Corp Plc (AMRN)

[Chabojilo]

How does he define 'plain ol fish oil'? 425mgEPA 425mgDHA and filler? Fine, that probably won't help at risk cardio patients...

How about a PlusEPA which is 90% EPA at 500mg, what if you take 2 pills of PlusEPA a day? How about 4 or 8 pills???

Topol says dose doesn't matter? That can't be concluded from this study when you didn't run comparison doses.

[jessellivermore]

North...

"The recommended dosages of Vascepa[2x2/day] may well be different---certainly not to be equated with fish oil"

The good Dr. Topol needs to educate himself, as does the New England Journal of Medicine, JAMA, and probably most PCPs and cardiolodists (and yes I am an MD)

A gram of garden variety fish oil you buy at GNC, or Whole Foods averages around 175mg of EPA per tablet. Most people are taking one a day...The principal effect of the omega-3s in fish oils, on CVDs (and other degenerative diseases) is to counter the chronic inflammation related to high AA levels resulting from diets high in Omega-6s and fast acting carbs..

EPA provides most of the anti-inflammatory effect, by slowing the conversion of omega-6s into AA, and by competing with AA for cell membrane receptors which control chronic inflammation..This competition means the effects of EPA are highly dose dependent. Taking one or two fish oil pills a day does not provide adequate EPA to produce a significant effect...

":>) JL