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Replies to #69549 on Biotech Values
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masterlongevity

12/05/08 12:41 PM

#69550 RE: DewDiligence #69549

Hi Dew, Can we get a new survey? Worst biotech exec of 2008..

II would suggest Kelly Martin from Elan on the list for his ashamedly pre-promtion of bapineuzimab prior to negative results. Thus, the preciptious drop from $37 to single digits. The people on the IV board are also creating revisionist history by blaming the share price on the credit markets. However, the stock dropped to single digists prior to market meltdown.
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DewDiligence

12/11/08 1:13 AM

#69901 RE: DewDiligence #69549

MNTA ReadMeFirst

[Updates:
Anticoagulant index (competition);
musings on MRK’s standing in FoB arena;
a single new post on the likelihood of a Lovenox ‘authorized’ generic
has replaced a makeshift section of the old ReadMeFirst on this topic.]



What is MNTA’s business all about?
#msg-31026200 Transcript from 2Q08 CC
#msg-28748329 MNTA helps FDA with contaminated heparin
#msg-33978205 Post-mortem on above story
#msg-32450075 2008-2009 news flow
#msg-25473104 Capsule explanation of proprietary technology
#msg-33867074 2003 article from Signals (still a good read)
#msg-19626947 Sugars, peptides and glycoproteins, in that order
#msg-24624700 Apropos to above (2005 PR)
#msg-28865474 Characterizing a compound by “ruling out” structures
#msg-33498974 Tidbits from 11/11/08 DB webcast
#msg-29053373 Tidbits from 5/5/08 DB webcast


Valuation and finances
#msg-33301993 3Q08 financial results
#msg-33862924 $95M cash balance is more than sufficient
#msg-29008722 Musings on valuation
#msg-3397119 IPO 21-Jun-2004 @6.50/sh
#msg-8410708 Poison pill adopted (11/8/05)
#msg-25377212 Standstill agreement with NVS expired on 7/25/08
#msg-33880685 Table of recent biotech buyouts


Management and BoD
#msg-12824293 CEO, Craig Wheeler, hired from Chiron
#msg-33979910 James Sulat appointed Chairman of Board
#msg-33986175 Composition of Board of Directors
#msg-33986764 Insider shareholdings
#msg-28899840 Largest shareholders
#msg-27338039 James Roach appointed CMO


Generic Lovenox program
[See section below re ‘authorized’ generic from Sanofi.]
#msg-32449872 Sandoz submits response to FDA
#msg-33862924 Sandoz pays the freight
#msg-33839164 Profit split depends on # of generics
#msg-33892399 Musings on MNTA’s slice of Lovenox pie
#msg-34007446 Sanofi likely to launch an ‘authorized’ generic
#msg-33858393 What about ANDA’s from Teva and Amphastar?
#msg-33960572 HSP filed ANDA for vial only
#msg-33311968 Amphastar’s 180-day clock has started
#msg-33839413 Estimated royalty if multiple generics
#msg-12685766 Royalty payable to MIT
#msg-33246663 Lovenox sells $3.2B/yr, 59% in US
#msg-28934793 Could be largest-selling generic of all time
#msg-26739674 Lovenox US market share
#msg-28936334 What indications do Lovenox sales come from?
#msg-12222305 2006 agreement extends partnership to EU
#msg-29728035 How generic Rx’s are written in EU
#msg-29698599 Competition from new oral anticoagulants


M118 (proprietary anticoagulant) program
#msg-26897124 “Checklist” rationale for M118 program
#msg-26900300 M118 has blockbuster potential
#msg-32382532 Program update from UBS webcast (9/23/08)
#msg-29698599 M118 vs new oral anticoagulants
#msg-27272430 Meeting an unmet need
#msg-26898084 How M118 binds both FIIa and FXa (graphic)
#msg-32382585 M118 clinical trials
#msg-31029674 Musings on lack of drug interactions


Generic Copaxone program
#msg-30621490 FDA accepts Copaxone ANDA for review
#msg-30938608 MNTA/Sandoz have first-filer status
#msg-33580867 MNTA/Sandoz allege inequitable conduct
#msg-30960930 List of Copaxone patents being challenged
#msg-30649453 Notes from 7/11/08 Copaxone conference call
#msg-26893858 Musings on upside of Copaxone program
#msg-30647865 “Controlled Chaos” (reverse engineering)
#msg-12222305 Copaxone falls under 2006 collaboration
#msg-33370803 Copaxone sales keep growing
#msg-31152081 Copaxone is world’s biggest MS drug
#msg-32316091 Copaxone data in CIS
#msg-31249570 Tysabri forecasts unrealistic, analysts say
#msg-29902618 Mylan enters the fray—sort of.
#msg-30498483 Teva’s trial with 40mg dose fails
#msg-31515145 FTY720 setback
#msg-31519342 MS drugs in phase-2 or phase-3


Follow-on Biologics (FoB) programs
#msg-27114485 US FoB’s are a question of when not if
#msg-33759265 Rep. Dingell’s ouster good for FoB prospects
#msg-26837144 Salient FoB quote from MNTA’s CEO
#msg-12222305 2006 partnership includes two FoB’s
#msg-25514154 Speculation on the FoB’s to be developed
#msg-20699044 Largest-selling biologics by class
#msg-34108345 Musings on MRK’s standing in FoB arena
#msg-33866262 Reference website for FoB’s


Competition
#msg-34108304 Anticoagulant index
#msg-29698599 Competition from new oral anticoagulants
#msg-33839321 Procognia is not a serious competitor
#msg-33630772 CHEST 2008 study on Lovenox vs Arixtra
#msg-33597614 Also-ran companies in the FoB arena


Feature stories on MNTA and related topics
#msg-27286206 Boston Globe (3/08)
#msg-25160571 WSJ (12/07)
#msg-25933221 Bioworld (11/07)
#msg-23005127 Nature (9/07)
#msg-20308884 Lab Technologist (6/07)
#msg-25803923 The Pink Sheet (3/07)
#msg-13119848 Chemical & Engineering News (9/06)
#msg-12686142 Boston Globe (8/06)
#msg-7370282 WSJ (8/05)
#msg-25779774 Boston Globe re IPO (11/04)
#msg-2220442 Boston Globe (1/04)
#msg-33867074 Signals (9/03)