<b> Largest Biopharmaceutical Classes </b> (Sales figures are worldwide for 2006.) 01* EPO <b>$11.9B</b> (Aranesp, Epogen, Procrit, NeoRecormon) 02. Cancer mAbs <b>$10.6B</b> (Rituxan, Avastin, Herceptin, Erbitux, etc.) 03. TNF-a <b>$10.3B</b> (Remicade, Enbrel, Humira) 04. Insulin and analogs <b>$10.0B</b> (many products) 05. Recombinant plasma proteins <b>$4.7B</b> (e.g. NovoSeven) 06. Interferon beta <b>$4.4B</b> (Avonex, Rebif, Beteseron) 07. G-CSF <b>$4.4B</b> (Neupogen, Neulasta) 08* hGH <b>$2.5B</b> (many products) 09. Interferon alpha <b>$2.3B</b> (Pegasys, Peg-Intron) 10. Enzyme replacement <b>$1.7B</b> (e.g. Cerezyme) 11. Antiviral mAb <b>$1.1B</b> (Synagis) 12. FSH <b>$1.0B</b> (Gonal-f, Puregon) Total 2006 sales of these classes: approximately <b>$65B</b>. *Follow-on biologic has been approved. Source: <A HREF="http://www.pipelinereview.com/Top_20_Biologics_by_La_Merie.pdf" target="_blank">http://www.pipelinereview.com/Top_20_Biologics_by_La_Merie.pdf</A>