Biotech Values

[DewDiligence]

MNTA/M118 – Further to the lack of a drug interaction between M118 and aspirin or Plavix, M118 may have an edge vs LMWH’s such as Lovenox on this score. The FDA label for Lovenox cites a potential drug interaction with aspirin; although Plavix is not mentioned by name, the Lovenox label cites platelet inhibitors as a class:

http://www.fda.gov/cder/foi/label/2007/022138,020164s075lbl.pdf

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DRUG INTERACTIONS

Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid [aspirin], salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring.
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The bigger advantages of M118 vs Lovenox are FIIa inhibition and reversibility (#msg-26897124).


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