Replies to post #175857 on Anavex Life Sciences Corp (AVXL)

[Steady_T]

Affinity for a receptor is not the same as activation strength of that receptor.

There are many factors interacting in this complex chemical/biological system.

If that were not the case the causes of AD would be well known by now.

What we are discussing is one detail in a complex system. Mostly because it is one of the few things that we know about to discuss.

This is not a complete black box, but much of what is happening with AD and 2-73 is opaque.

[Investor2014]

Progesterone is a potent antagonist of S1R.

Using an S1R antagonist can block out the effect of an S1R agonists, which is the way that a preclinical study can filter out the effects of e.g. DZP S1R agonism to see if the drug continues to have a particular effect or not.

In a previous post I referenced a study that found the therapeutic effect of DZP disappeared when murines were S1R antagonised to block the equivalent DZP agonistic effect.