Replies to post #1661 on GTC Biotherapeutics (fka GTCB)

[gfp927z]

Dew, Sepsis has always been a graveyard for pharma development. I wonder if reliance on this program is one of the reasons for GTCB's overall weakness?

[DewDiligence]

GTCB ReadMeFirst

[Updated re competing programs in
DIC/sepsis; miscellaneous minor changes.]


What is GTC’s business all about?
#msg-11412472 The new GTC!
#msg-11432468 FAQ
#msg-9243634 Jan 2006 interview with CEO, Geoff Cox
#msg-9352093 2002 interview with Tom Newberry (dated, but informative)
#msg-13171505 “Production of Recombinant Therapeutic Proteins in the Milk of Transgenic Animals” (recommended for the more technical reader)


Valuation and finances
#msg-14474900 Latest financial results and cash guidance
#msg-14509476 Addendum on cash usage and future financing
#msg-11409187 Rodman & Renshaw $4 target
#msg-11037571 Valuation comparator: MRK paid $400M for GlycoFi
#msg-13731209 Effective share count for valuation purposes
#msg-13849491 ‘Enterprise value’


Upcoming events
#msg-14496600 Possible/probable 2006-07 news flow


BoD composition and insider shareholdings
#msg-14202968 Composition of Board of Directors
#msg-14203089 Current insider shareholdings


ATryn hereditary-deficiency program in Europe
#msg-11752181 Why ATryn?
#msg-11399356 ATryn approved by EMEA
#msg-11399033 ATryn Q&A from the EMEA
#msg-12399714 EU Commission clears ATryn for marketing
#msg-8316050 Leo Pharma partnership announcement
#msg-12430822 Economics of the Leo partnership
#msg-14545343 HD sales projection
http://www.atiii.com What is hereditary AT deficiency? (simple)
http://tinyurl.com/yb9hl5 What is hereditary AT deficiency? (technical)
http://tinyurl.com/yh8g2k Official product label


ATryn hereditary-deficiency program in U.S.
#msg-14545317 U.S. ATryn timeline
#msg-6543884 Non-availability of competing antithrombin
#msg-5607789 Efficacy endpoint is clinical DVT
#msg-5609005 Design of control arm
#msg-11410659 Likelihood of success
#msg-6632420 Patient eligibility and exclusions
#msg-11511614 Musings on a U.S. partnership


ATryn DIC/sepsis program in Europe
#msg-14363831 Rationale for pursuing DIC/sepsis indication
#msg-14516396 How sepsis causes DIC
#msg-12483101 Existing therapeutic options are weak (Xigris)
#msg-12480268 Surprising sepsis factoids
#msg-8316050 Leo Pharma partnership announcement
#msg-12430822 Economics of the Leo partnership
#msg-12511434 Phase-3 timeline
#msg-14495208 When will GTC receive milestone payments?


Miscellaneous info on ATryn and antithrombin
#msg-7306242 Which antithrombin will doctors prescribe?
#msg-4372780 Risks of plasma-derived proteins
#msg-13209941 Risks of plasma-derived proteins (addendum)
#msg-9502819 A patient’s story
#msg-14363731 Reference list of AT abstracts and articles


GTC-LFB program in Factor VIIa (and other therapies)
#msg-13731860 Who is LFB?
#msg-13956439 Who is LFB? (addendum)
#msg-13708619 Partnership terms (press release)
#msg-13817609 Partnership terms (SEC filing)
#msg-13782980 Overall framework is 50/50 cost and profit split
#msg-13763244 Size of addressable Factor VIIa market
#msg-13712057 Uses of Factor VIIa (see below for more on NovoSeven)
#msg-13873990 Musings on LFB deal (Dew)
#msg-13845005 Musings on LFB deal (‘chatalinda’)


NovoSeven (recombinant FVIIa from Novo-Nordisk)
NovoSeven website: http://www.novoseven-us.com
#msg-13980605 Price of NovoSeven
#msg-14084250 NovoSeven for acquired hemophilia
#msg-13925693 NovoSeven for trauma


Miscellaneous research and development programs
Capsule summaries: http://www.transgenics.com/products/prod.html
#msg-14493025 Timeline chart of in-house and partnered programs
#msg-13797351 Grant for CD137 antibody program
#msg-8163705 Merrimack program in RA
#msg-10727170 Merrimack program in psoriasis
#msg-8111599 Economics of Merrimack relationship
#msg-7136629 Collaboration with Scancell
#msg-4316445 ATryn research contract with U.S. army


Intellectual property
#msg-9174865 Production (“milk”) patent
#msg-7179529 Purification patent
#msg-14493913 Pending patent applications
#msg-13154218 Nuclear-transfer IP from Geron
#msg-4107224 IP license to PharmAthene (formerly Nexia) for Protexia
#msg-14110344 Government grant for Protexia


Existing and potential competition
(See separate heading above for NovoSeven.)
#msg-7221666 Price and availability of commercial plasma-derived AT
#msg-11909951 Thrombate AT from Talecris
#msg-14524596 Artisan Pharma thrombomodulin
#msg-14527640 Comments on Artisan’s program
#msg-14536810 Tifacogin for sepsis (NVS)
#msg-14176380 AM-Pharma program in sepsis
#msg-14499024 AZN/Protherics program in sepsis
#msg-13763492 ‘Enhanced’ rFVIIa from Roche, Maxygen
#msg-11829819 Talecris AAT
#msg-6488263 PurelyProteins AAT (market-size info)
#msg-13169472 GlycoFi/MRK (humanized yeast glycosylation)
#msg-13222976 More on the GlycoFi story
#msg-7542154 Origen’s transgenic chickens
#msg-10846766 Biolex Therapeutics (Locteron)
#msg-5919466 Biolex ‘plantibody’ patent
#msg-12155688 SemBioSys Genetics
#msg-14191540 Prairie Plant Systems
#msg-8863527 Companies to watch (Drug Discovery & Development)


Feature stories on GTCB and transgenics
#msg-13365243 Times of London (9/06)
#msg-13152292 Nature.com (9/06)
#msg-14278650 Biotechnology Healthcare (8/06)
#msg-12573463 Nature Biotechnology (8/06)
#msg-12273566 Boston Globe profiles Dr. Harry Meade (7/06)
#msg-11635041 Framingham, Mass. Daily News (6/06)
#msg-9243634 Red Herring (1/06)
#msg-9143261 Business Week (1/06)
#msg-8162424 Scientific American (11/05)
#msg-6806806 Wall St Transcript interview with Tom Newberry (6/05)
#msg-6775592 Newsweek special issue on healthcare (6/05)
#msg-6276428 Worcester, MA Telegram & Gazette (5/05)
#msg-7431316 Nature Biotechnology (10/04)
#msg-4057315 The Economist (9/04)