Replies to post #140839 on Anavex Life Sciences Corp (AVXL)

[georgesk]

I think he's adjusting for body mass (Rett is targeting children).

I have no idea if that math is right or wrong however. Not my expertise. Would love a 2nd opinion from someone who understands drug effects VS body mass.

[OFP]

That makes no sense considering that the company has said the minimum effective dose is 14 mg.

If you revisit where the 14mg number came from you will see that it no longer holds any relevance. You'll notice the company has not dared repeat that silliness in years.

[F1ash]

That makes no sense considering that the company has said the minimum effective dose is 14 mg.

Further the data indicates that higher doses than that are required to get blood concentrations up to desired levels

The numbers you quoted come from data related to possible Alzheimer’s efficacy.

I was trying to get folks to calculate their own estimates for Rett dosing. It’s not bashing or pumping, just something that I believe can be helpful if one is investing in biotech’s. I don’t claim to be expert at it, so perhaps others can give it a go?

Companies use preclinical data (mouse models in this case) to find a dose that produces the results they are hoping to see, then they translate that dose into a “human equivalent dose” (HED)

“Therefore, I thought I'd post here the details regarding precisely how the HED can be calculated.

In short, the relevant formula is as follows:

HED (mg/kg) = Animal Dose (mg/kg) x [Animal Km / Human Km]

Human Km = 37

Mouse Km = 3

Rat Km = 6

EXAMPLE:

Say a STUDY conducted on MICE reports that a dosage of 5mg/kg was used; what is the HED?

By calculation, the HUMAN EQUIVALENT DOSE (HED) = 5 x [3 / 37] = 0.405 mg/kg “

http://www.longecity.org/forum/topic/58082-how-to-convert-dose-from-animal-to-human/

More details at the following link:

https://www.fda.gov/downloads/drugs/guidances/ucm078932.pdf

Now here is the Preclinical mouse data for A2-73 in Rett.

See page 6 for seizure related mouse dosage for example.

http://www.anavex.com/my_uploads/Assessment-of-Anavex-2-73-in-a-MECP2-Rett-Syndrome-Mouse-Model.pdf

Anyone care to to solve the math problem and put their work up on the board?