News Focus
News Focus
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md1225

11/30/16 4:34 PM

#85690 RE: Rkmatters #85687

Ughhh great stuff RK now I'm thinking about adding more to my next article....

That's already finished!
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flipper44

11/30/16 4:40 PM

#85691 RE: Rkmatters #85687

Thank you so much RK. I had not read that before. Everything was very interesting, and I found this somewhat telling.

The interaction between T cells and dendritic cells is a cognate interaction in which T cells recognize the specific antigen being displayed by the dendritic cell. -- https://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/steinman_lecture.pdf

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CherryTree1

11/30/16 6:52 PM

#85702 RE: Rkmatters #85687

I am all for Ralph Steinan being nominated for discovering dendritic cells, but Linda Liau should also be nominated for advances in figuring out how to make the work against cancer.
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Tadasana

11/30/16 8:14 PM

#85704 RE: Rkmatters #85687

Wow! That's some Grapefruit Juice! I'll take some of that, please. Rk another big thank you! Great read! We are building on some great discoveries! Decades in the making, really close now. Put things in perspective when you see where it all started and how long the process has been. Progress and change are slow, the Universe is 14 Billion years old? and it gets revised all the time. Go NWBO!
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eagle8

12/01/16 8:59 AM

#85752 RE: Rkmatters #85687


Thank you so much RK for sharing this article with us.
Very, very interesting ofcourse.

GLTU
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doingmybest

12/01/16 9:28 AM

#85754 RE: Rkmatters #85687

Rk, thx for this article. So interesting to trace the history of something so important. I am always so curious to understand why BP jumped into a breakthrough or not and if not, why not. A lot can be said about why BP focuses where they do. Alzheimers research had some channeling of thought it appears and it looks like after decades of trying they are back to the drawing board on that one. It will probably take a small lab to make the Alzheimers breakthrough needed. Dendritic cell research may have been bucketed into cell therapy and somewhat discounted, or, maybe the IP was not considered satisfactorily protective of large scale investment, or, maybe it was seen as less potent. But, it is starting to emerge that BP, at least to date, has missed the boat with DC therapy. Good for all that NWBO took the all in approach. Now BP will partner it or buy it depending.

I saw the commentary on the Sawston facility being paused. It is key to pause a large scale capital project intelligently and with foresight to avoid major complications in contracts and timing and cost. I guess they have accomplished that and in my guess will probably lose around 6 mos from where they could be in site development. It will cost a little more but if the main use of the capacity was actually for Direct and that has been delayed it will not be a major issue in timing. Given their financial challenges there is a need to take drastic steps and this may just be one of them. As I have said before a site project like this, basically from the ground, is a good 3 year project to startup, could be a little longer depending. It will take them a year to qualify the plant once all construction and equipment installation is done and technical staff is on the grounds. It sounds like they are about halfway done, which may be great for the long term plan.

Good to have P3 data in hand soon.