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And let's not forget that these great results were from Phase 1 SAFETY trials, they were not even optimized as to dosage size and schedule.
Here is a Phase 1 trial definition, for those who are DD-impaired.
Not only the gift of life, but with few or no side effects, based on what data we have so far.
Compare that to regular chemotherapy.
4 clinical trials, 4 different applications. What else needs to be said?
If you were taken out on a stop, presumably it was higher than here. You can get back in for less than your stop-out point.
If you believe that the FDA, a world-class research institution, and any number of other doctors and scientists are more credible than a stockbroker who hides behind a silly name to write a malicious, libelous bashing article -- then why would you not want to invest in a company like this?
Not investment advice, of course. But there must have been some reason why you bought the stock in the first place. Has the science changed for the worse since then?
I had the same thoughts about a mortgage, which shows how absurd this is getting.
Vast fortunes have been made by the short gang. I use the term advisedly and literally. It will pale in comparison to what is made on the long side.
Characterizing something as a "fortuitous bit of clinical happenstance" is disingenuous.
The CEO of the company has far more data than he can publicly disclose. The fact that he chose to disclose that, after probably being inundated by shareholder queries, indicates his confidence that the data will prove to be meaningful.
This company has possible treatments or perhaps even cures in 4 ongoing human trials, for:
cancer
resistant infections
oral mucositis
psoriasis
Anyone who thinks that a stock should be trading at this low market cap when it has this number of clinical trials, QIDP designation from the FDA, trials being run by one of the most prestigious research centers in the world, and an entirely NEW family of antibiotics (the first since 1987) -- well, I can't even find words to express my disbelief that anyone could actually believe that, much less write it with a straight face.
Clearly you do not understand the pipeline. This is far from a "garbage company" -- it has just been attacked by garbage article writers. I use the plural because I do not believe Mako is smart enough to have written that by himself.
You were calling for a low price for entry for a very long time. I have had some of my best trades when I got into a biotech too early, and then doubled down. Think about it. (not investment advice)
I did that with the other stock many of us are in and have profited greatly from it.
We have been torpedoed by a malicious article and continuing market maker shenanigans. When I put in a bid above the ask and still can't get a fill, does that tell you anything?
A long term hold strategy is EXACTLY what is needed here. The absolute lies that were stated, panicking the ignorant who did not understand what the company did, are the cause of this falling price. There is NOTHING wrong with the science of this company.
The other stock that many of us are in fell off the cliff several years ago. Those who doubled down (well, actually they would have to at least triple down) are now whole on their investment, and that company is significantly behind CTIX in getting to a Phase 3 trial and submission for approval.
I absolutely believe that those who have the courage to buy now in the face of this idiocy will be rewarded richly.
I did not correctly credit Sox for the list of catalysts to be expected in the near future.
Here is SOX's list again:
Catalyst!
Re-Posting:
Q3 Milestones / Upcoming Catalysts
- Start of B-ABSSSI (Phase 3)
- Start of K + cytarabine (Phase 2)
- Completion of K (Phase 1)
- 10-K (mid-September)
- NASDAQ uplisting
Past Milestones
- QIDP designation for B-ABSSSI
- K orphan drug designation for ovarian cancer
- Start of B-OM (Phase 2)
- Start of P (Phase 2)
- B-ABSSSI positive Phase 2b top-line & bottom line data
- Completion of cohort 10 (450 mg/m2)
- P (Phase 1) primary endpoint met
- Stable formulation of B at room temperature
- Signed agreement for testing B in implanted devices (after FDA approval)
Clinical Trials
1. P (Phase 2, recruiting): https://clinicaltrials.gov/ct2/show/NCT02494479?term=cellceutix&rank=1
1. P (Phase 1, completed): https://clinicaltrials.gov/ct2/show/NCT02101216?term=cellceutix&rank=2
2. B-OM (Phase 2, recruiting): https://clinicaltrials.gov/ct2/show/NCT02324335?term=cellceutix&rank=3
3. K (Phase 1, recruiting): https://clinicaltrials.gov/ct2/show/NCT01664000?term=cellceutix&rank=4
4. B-ABSSSI (Phase 2, completed): https://clinicaltrials.gov/ct2/show/NCT02052388?term=cellceutix&rank=5
Abbreviations
K – Kevetrin
B – Brilacidin
P – Prurisol
OM – oral mucositis
ABSSSI – acute bacterial skin and skin structure infections
QIDP – qualified infectious disease product
You are very wrong about the news items that could be released in the very near future.
List compliments of daydreaming2
Catalyst!
Re-Posting:
Q3 Milestones / Upcoming Catalysts
- Start of B-ABSSSI (Phase 3)
- Start of K + cytarabine (Phase 2)
- Completion of K (Phase 1)
- 10-K (mid-September)
- NASDAQ uplisting
Past Milestones
- QIDP designation for B-ABSSSI
- K orphan drug designation for ovarian cancer
- Start of B-OM (Phase 2)
- Start of P (Phase 2)
- B-ABSSSI positive Phase 2b top-line & bottom line data
- Completion of cohort 10 (450 mg/m2)
- P (Phase 1) primary endpoint met
- Stable formulation of B at room temperature
- Signed agreement for testing B in implanted devices (after FDA approval)
Clinical Trials
1. P (Phase 2, recruiting): https://clinicaltrials.gov/ct2/show/NCT02494479?term=cellceutix&rank=1
1. P (Phase 1, completed): https://clinicaltrials.gov/ct2/show/NCT02101216?term=cellceutix&rank=2
2. B-OM (Phase 2, recruiting): https://clinicaltrials.gov/ct2/show/NCT02324335?term=cellceutix&rank=3
3. K (Phase 1, recruiting): https://clinicaltrials.gov/ct2/show/NCT01664000?term=cellceutix&rank=4
4. B-ABSSSI (Phase 2, completed): https://clinicaltrials.gov/ct2/show/NCT02052388?term=cellceutix&rank=5
Abbreviations
K – Kevetrin
B – Brilacidin
P – Prurisol
OM – oral mucositis
ABSSSI – acute bacterial skin and skin structure infections
QIDP – qualified infectious disease product
I had the same thing happen, can't get a fill even when going in ABOVE the ask.
Sickening.
I disagree completely. You have made your position very clear.
I love how people attack a company for trying to overcome a malicious article that was filled with lies, which damaged the company.
It's kind of like telling a mugging victim that if they report the mugger, the victim is at fault.
EDIT: by the way, I feel fine saying that the article was malicious and filled with lies, because the defense against libel is truth. That article has no such defense.
ORPHAN DRUG designation -- you don't get much rarer than 400 cases a year.
I don't know, don't you think when CTIX announces that Mako was identified and is being sued, that ought to help the stock?
You don't understand -- people were buying at 32 and 40 and 55 -- THEY got slaughtered.
It's a pump and dump for most who bought. Except a lot took losses, or even worse are still holding it with huge losses. It was trading at an absolutely crazy valuation this morning -- THREE TIMES what it closed at. How is that good for most of the people who bought and lost money? Am I missing your point?
I bought stock all day. This company is absurdly underpriced for even ONE clinical trial -- and it has clinical trials for 4 different applications, with 3 different drugs, any one of which could be a blockbuster. I find it difficult to envision a circumstance that would prevent approval for Brilacidin (antibiotic, for those who are new).
A treatment or cure for some forms of cancer; a novel class of antibiotics (first new class since 1987) that is as or more effective than the current standard of care; a novel treatment/preventive for debilitating oral mucositis; a possible treatment or cure for psoriasis.
On the business side, possible grants or partnerships.
Progress on any one of the drugs, and anything on the business end, and we should achieve new highs.
In my opinion this stock is currently trading at 1/4 its value, at most.
So tell us, if the New York Times prints something untrue, it prints a correction. It does not leave the article uncorrected on its website.
What do you think of a website that is informed multiple times by many readers that it has posted inaccurate and even libelous claims that are easily refuted with facts -- links to which we attach to our emails -- and yet the website refuses to remove the article? What do you think that says?
I disagree, I think that the other stock shows what determined pumping and mass mania can do. Think how those idiots who bought at 55 feel about its close at 18+. Or even the people who bought at 32, thinking it had bottomed.
I know first-hand that a couple of private traders' rooms were gaming it.
Take a look at what the company does, do a little DD, and you will see how totally stupid and manipulated that action was. Another one for the Efficient Markets Theory Hall of Fame.
They are going to try to close this under 2. I hope that some have some dry powder left for the close.
Why would I do that? I like you and want you to make a lot of money!
I have been buying all day and will continue to do so.
Given that the animals were what we euphemistically call "sacrificed" and pinned to an exhibit board (remember those pictures?) I think we can safely say that their condition has not worsened. LOL !
I hope for the sake of those people who got burned on the other that it DOES go up hugely. That would also make me feel good, since the people who dumped it would feel stupid.
I'm really sick of being accused of bashing. If people would actually read my posts without a knee-jerk response perhaps they would understand.
Good luck to all of you who are genuinely long, and goodbye.
Sarcasm overkill, removed by poster.
I'm selling other stock to buy more CTIX tomorrow. It is sickening to think of profiting from the actions of the shorter's syndicate, so I will publicly pledge here that the massive profits I will be making from my new shares will be going to charity.
Thanks for the large amount of time you must have spent researching those allegations. Excellent work.
When mud is flung, some of the stain remains even after the mud is cleaned off. We've seen these kinds of unscrupulous actions by media many times. Hopefully there will be some new data soon that will squelch this.
There's a difference in what happened to the two stocks you mentioned. TPIV was pumped by the traders' gangs and just as quickly fell back to earth when they grabbed their profits (at the expense of the naive, and the less-quick traders) and ran.
CTIX has been torpedoed by what appears to be a well-funded shorting group. Many of us here are CTIX investors. I remain confident that the incredible science and pipeline that CTIX has will give me amazing financial returns someday, as well as alleviating human suffering in at least 2 or 3 distinctly different areas.
I also think that AVXL has an incredibly promising possibility here, especially because (as I have said here ad nauseam) they are the ONLY company that has shown promising data from NOT following the conventional wisdom, said "wisdom" having proved to be an abject failure.
HOWEVER: to think that AVXL is immune from the actions of the traders' gangs is just foolish. If someone posts an article filled with libelous, untrue allegations (as they did with CTIX) in concert with a shorters' gang, they could do the same thing to AVXL. Or if the traders' gangs pull out of their positions, the stock could fall (and then they'll appear here again, pumping away after they re-load).
I plan to hold tight to my AVXL core position, and I am NOT going to panic and sell if it goes down. I'm also not going to assume that it's going to be at 5 bucks in a couple of months -- as much as that would make me, and my account, happy. I'm in for the long haul.
Please don't call me a basher again, either, if you've been reading you know I've been presenting all kinds of stuff in support of this company.
That's another motive for the attack, for any who wondered.
"Opinion" does not include calling people thieves who will steal in the future. Nor does it include taking pictures of an office with pitch-black windows (clearly at night) and claiming they are taken during office hours and thus proof that the office is abandoned. Nor does saying that the office building is abandoned. Nor is if "opinion" to refer to a company 17 times as a "shell" company when by no stretch of definition, even colloquialism, can the company be called a shell. Nor does saying that no one answers the phones, and that if one gets the message, that there is no way to leave a message (but the receptionist sounds "drunk"). That latter may be the one item that is "opinion" but a reasonable person (the standard used for juries to make their decisions) could in NO way agree that the crisp, professional message sounds "drunk." I've heard the message. That claim is defamation, pure and simple.
There are many other things like that which are not part of the science, but they are also provably untrue.
I sure hope that everyone understands that the anonymity of the internet is not enough to allow you to make defamatory comments if someone gets mad enough to sue. We've seen cases before where people went after anonymous people on the internet, and it may happen again in the VERY near future.
But we don't have results for the full cohort yet. When we do, if they are as good as these preliminary results, I say it's party time, major bigtime.
It is not difficult to understand that even though opinions are protected, it is not allowed under law to accuse someone of being a thief who is going to steal from a company. Defamation is a bit more slippery but in this case would actually be easier to prove, because the company and the individuals involved have written an article which states as truth things that are provably untrue, makes allegations about the character of the "insiders" when accusing them of being "likely" to commit future crimes, and clearly HAS caused financial damage on the basis of these allegations. This is clearly proven by the statement of the ambulance-chaser firm, which said that the article "revealed" these allegations (and thus claimed them as truth although minimal investigation would have shown their falsity.)
A libel/defamation lawyer would have a field day. I hope that the company pursues it although I doubt that they will. Sometimes it's worth it to lose money on legal fees in the interests of pursuing justice.
That is incorrect. Someone can't say "it's my opinion that so-and-so is a thief who is going to steal from the company." That CAN be refuted, and it is libel. It is not an opinion that is protected speech. It is an allegation of future wrong-doing, and is actionable in a court of law.
Unfortunately most of the time libeled parties do not go after the libelers, both because doing so causes even more attention to those statements, and because the time and aggravation is usually not worth it to the victim.
12 IS a small sample. It doesn't matter how many more will be in the trial eventually, the number mentioned for these very encouraging preliminary results is a small sample.
Alzheimer's is a difficult disease to quantify because measures of cognitive function are open to interpretation. Some of the tests may measure something, but changes of cognition observed by caregivers who are very familiar with the patient's capabilities before and after the drug is administered are of more use (because quantified measures of cognition can be very deceptive, if they're not measuring the right thing).
So yes, the BEST data we have, the impressions of the caregivers, are in fact anecdotal. And we also have the problem of the "wishful thinking" bias aka the placebo effect. Desperate people are anxious for any sign of improvement in their loved ones. As great as these first results seem to be, we need results from MORE patients, when we have some idea of what the optimal dose is. That's why we have clinical trials.
I am extremely encouraged by the results. I have said for years that Alzheimer's drugs were going after the wrong target, and I invested in AVXL (yay!) and PRAN (sigh) because they were the only companies that seemed to be researching in OTHER directions.
I am bullish on this stock, I own a ton of shares, and frankly I am disgusted at the reactions of some of the posters on this site who become irate if someone doesn't either cheerlead the stock, or bash it, depending on what they'd like to read.
Boy, no one seems to understand what I'm saying. Everyone has a knee-jerk reaction that any post that implies the stock might ever go down is bashing it.
Quite the contrary. I am warning people DO NOT BE A SUCKER.
Don't let these guys scare you out of your stock. That's what they do -- they take the stock down far enough that the pain gets people to sell. Then when the stock goes back up, people are so mad and scared that they don't get in again. But guess who DOES have shares and adds? Yep, the very people who scared the suckers out of their stock.
I am in NO way criticizing those who traded the stock based on share price movement, and did not dishonestly try to talk the naive into either jumping on board, or selling, whichever they needed. That's trading and that's fine.
What galls me is the traders who talk the stock up or down, purely for the point of manipulating the price of a (well, until recently) thinly traded stock.
Govorchin may have been right when she first suggested that Leo called Dana-Farber and said that he had to release a small nugget early to staunch the bleeding.
I am going to be buying tomorrow. More than loaded to the gills already, but this is the opportunity of a lifetime -- for which I still detest the shorters' gang that did this.
Think about how Martha Stewart went to jail for a small thing -- and these criminals who have cheated people out of millions of dollars walk away scot free. Sickening.
Excellent find, Minotaur. It should also be noted that autopsies of healthy older people have revealed that many also have significant amyloid plaques BUT they had NO Alzheimer's symptoms.
Decades of wasted research, chasing the wrong target. Just imagine if no one had ever research the germ theory, because all they focused on what the "humors" that supposedly caused disease. That's where we are with Alzheimer's right now -- except for AVXL and, sadly, PRAN.
Why didn't SA remove the comment about crayons etc.? More to the point, why didn't they remove the article entirely, since many of us reported the complete factual inaccuracy, with proof? (At least I did, and others have said they did too.)
IMO, anyone who buys CTIX here will do VERY well financially in the not too distant future.
I suggest that people save some energy because I expect the heretofore absent bears will be in full force tonight, trying to panic people so that they can try to run the stock down tomorrow to take out more stops.
Once again:
DO NOT PUT STOPS IN A SMALL BIOTECH.
The market makers WILL take you out. I suspect that the reason the stock took that very very brief dive to 1.36 on Friday was that someone had put a stop there, and got taken out. Remember that market makers can SEE your stops on their order book and they WILL take you out if they can, when they expect the stock to go up.
When a friend told me that he had put a stop on a large-cap stock for his 1,000 shares, and that a market maker had swooped down 80 cents to take him out -- I scoffed (mentally). (This was a stock that typically had spreads of one cent between bid and ask.)
Then it happened to me. More than once -- I'm a slow learner.
If you feel that you just MUST have a stop, use a "trailing stop" which is linked to the price where the stock is trading (either by cents or by percentage) and which only your broker knows about -- NOT the market makers. You still may get taken out but at least you're not making it easy for them. Talk to your online broker's representative if you don't know how to use a trailing stop. Better yet, ride this out and don't let yourself get stopped out at all.