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They haven't updated the clinical trials web site because they don't care. They gave up on this trial a long time ago. It's over. It's done. It's a complete and total failure and they have known it for more than six years. They are using it as a red herring to keep your attention, but they are not focused on it at all. I mean, isn't that obvious? They are not the least bit concerned with releasing the data from this trial because that's not what they are working on right now.
In what absurdly delusional world would one have to live to actually believe they are focused on releasing this trial data? What else could possibly happen other than what is happening now to prove they are not? Put out a press release? I honestly think if they put out an official press release declaring this trial a total bust, there are many here who would simply refuse to believe it.
Just stop it already with the Merck buyouts. There are not going to be any Merck buyouts. This is a rinky-dink piece of s--- company that can't finish a 16-year-old Phase 3 trial and is run by total incompetents. The whole thing is a total disaster, a complete failure, and yet people will be on here years from now making excuses about why they still haven't released TLD and how Merck is quietly working on a $100 billion buyout. If there is one thing I can tell you with absolute 100-percent certainty, it's that the name Northwest Biotherapeutics has never come up in the Merck M&O department even once, much less the board room. Companies like Merck don't waste their time with losers like NWBO, and if they were ever going to buy the company they would have done it years ago. You really think they are sitting around waiting to buy NWBO so they can pay a huge premium following the release of earth-shattering data? That is so completely ridiculous it just doesn't even deserve comment. I've said it a thousand times - they could buy NWBO right now for next to nothing - it literally wouldn't even change one number on Merck's balance sheet. There is so much utter delusion about NWBO - some of it intentional, but some of it is just total ignorance. For some reason people think an interim data report from 2018 guarantees a successful trial, but all of these interpretations completely whiffed on that data report and what it left out. That report was not even close to complete, did not address the then-primary endpoint of the trial, and nobody even bothered to say "Whoa, wait, what's going on here?". That report was so bad that no credible journal would publish it, despite the company's desperate attempts to shop it around for months. They ended up having to pay to have it published with no peer review, and yet there's a whole contingency here who thinks that report is the Holy Grail because it was signed by a bunch of doctors, doctors who would put their name on anything as long as they get publication credit. Yeah, sure. The data in that interim report was so strong the company felt the need to change all the endpoints on the trial two years later! Ha! You can't make this stuff up. What a joke! They have nothing and that's why they are hiding the data now. They've been hiding the data for more than six years, since they did the secret efficacy interim assessment that showed the trial is A FAILURE! That's why everything changed, people. Don't you get it? Isn't that completely obvious to you like it should be? Everything changed after 2015. Don't you ever ask yourselves why? You think they just up and decided to change the whole focus of the trial on a careless whim? Maybe because the CEO was feeling frisky that day? I mean, seriously, why are allegedly smart people entertaining this nonsense? The clowns who run the company have lied to their shareholders over and over again (just like they did with that interim report) while they keep paying themselves and nobody has the least bit of concern, or even bothers to question what is really going on. What they did in 2020 by putting out multiple false deadlines was so outrageously, egregiously, and maliciously wrong it would have been scandalous if anyone actually cared about this company. It's mind-boggling. This has become a straight-up scam because the company is refusing to release the data on a trial where they locked data almost a full year ago. That just doesn't happen in the world of biotech. It means something is really, really wrong. It means they are hiding the data, plain and simple. There is no other explanation, and anyone with half a brain knows it. THEY ARE HIDING THE DATA BECAUSE IT IS A FAILURE!!!
This is almost entirely correct. The company gave up on this trial a long time ago. They have known it is a total failure for six years now, and they have kept playing games to drag things out as long as possible so they can keep paying themselves. And they have paid themselves very, very well. Their commitment to this Phase 3 trial is nothing beyond superficial words and going through the motions to make sure shareholders always believe something is coming, something is imminent, so stay tuned. It's all a lie. Since 2014, it's all been lies. How could any shareholder experience the broken promises of 2020, and the complete silence that followed, and not understand the scope of lies that constitute this entire operation? Dr. Liau disassociated herself from the company a long time ago, and is now committed to her own DCVax projects. She won't even mention Northwest Biotherapeutics or the CEO's name anymore. No love lost there. NWBO is a total failure, but they are going to drag this out until bitter end, until they are simply unable to get anyone else to give them money.
This is what happens emotion collides with science, and it is how science ends up corrupted. This Tweet is a sad reflection on what a disaster Scott Gottlieb was.
I could say the same for the NWBO fanboys and fangirls who are so wrapped up in the emotion of a cure for brain cancer that they can't see a corrupt company hiding the results of a failed trial. Oh, well. Everybody has to learn some way, somehow.
This is not an "extreme" speculation. After reviewing all the facts at hand, it is 100-percent reasonable and rational to conclude:
1) The Phase 3 DCVax-L trial failed, or was largely unsuccessful;
2) They are nearing certification on a new manufacturing facility;
3) They are holding off on announcing 1 until 2 is confirmed. That way they can temper the bad news with some good news.
Now, whether the certification of the manufacturing facility ends up benefiting NWBO shareholders remains to be seen. It is possible that it could, yes. But the company hasn't told us anything about how that will work and, more importantly, the Cognate precedent suggests otherwise. It is equally plausible that NWBO is about to become a manufacturing company, or that history will repeat itself i.e., Cognate and once again NWBO shareholders will be left holding the bag. I always go with precedent because once people show you who they are, you'd be a fool to not understand that's who they really are.
Regardless, the above scenario is far from an extreme outcome. It is perfectly reasonable and rational based on the facts we know. I believe this very scenario is about to reveal itself as soon as the manufacturing certification is in hand. The posters here are so obsessively focused on the DCVax-L trial, which is misguided because the company has known for six years that the trial is a bust, and both Dr. Liau and Dr. Ashkan gave up on it a long time ago. I believe NWBO has been 90+ percent focused on manufacturing for some time now.
Why is NWBO refusing to release the data from their Phase 3 trial when they locked the data before Oct. 5, 2020? (Hint: it doesn't have anything to do with COVID.)
flipper, you've always got some new hype to focus on. It's literally almost a weekly thing, and this has been going on for years. But none of the hype ever pans out. It never once has turned out that what you think they are up to is actually what they were up to. And the truth always turns out to be highly disappointing.
Even presuming the holdup is entirely tied to this definitional change, as you say, then why haven't they just told us that? I mean, why not? How much angst and doubt would that alleviate with one simple statement? Why won't they do that?
Well, I'll tell you why. Because it isn't true, that's why. Again, the point is quite simple and everyone here wants to over-complicate it. If the data had come out really good, they would have released it. It's that simple. You don't sit on good data. Nobody does. Nobody ever has. When you have good news, you want to share it with the world as quickly as possible. That's just human nature. Now, when you have bad news . . .
Every excuse that gets thrown on the table seems to be some proposed solution to inevitable bad data - whether it's endpoint changes, using historical comps, or waiting for a new definition of GBM. None of these excuses is about a successful trial. That's a fact, and we all know it. This company is scrambling to salvage something, anything, out of this failed trial. They are playing games, just like they always have. And worse, they are liars.
In a few weeks you'll be on to a new excuse. I can feel it now. Maybe SNO again? Could be. I appreciate the optimism, but the nonsensical nature of the excuse-making, when this company has shown us over and over again that they are never doing what we think they are doing or want them to be doing, is tiresome.
This company is just straight-up refusing to release TLD from a trial where they supposedly locked the data before Oct. 5, 2020. And nobody here even cares! It's just insane. The excuses just keep coming every day, pouring out, excuse after excuse after excuse. I am convinced this insane cycle will just go on forever. It's just bizarro-world. Nobody cares to even wonder why they are refusing to release the data. It's all about quiet periods, publications, COVID delays, and whatever myriad excuses are in this week, but no one really wants to ask the one simple but hard question. Why? If the data is good, then why are we waiting?
You people have been snowed so bad by a bunch of liars, and it's like you either don't know it, or you just don't even care.
Such a great response. Unfortunately, the insufferable struggle with only mildly subtle hints.
Amazing that we are still debating this and that some of you, to this day, are still denying they conducted an efficacy IA in 2015. It's ridiculous. She told us they were going to do one. It would have been completely irresponsible and negligent for them not to have done one. And, yet, some of you still think they did not. Why? Not because you have any evidence to suggest they didn't (whereas, yes, there is evidence they did and no denial from the CEO), but because you don't want to believe they did one because it destroys your whole narrative. And don't try to tell me about lawsuits that did not address the issue of an efficacy IA conducted in 2015.
The "Super Duper Double Secret Probation Efficacy IA" conducted in or around 2015 is central to this whole mess. It's a key piece of information that was withheld from shareholders, and I can tell you right now it is what is going to hang them in court when this debacle blows up. They disclosed the safety IA but not the efficacy IA? Hmmm, perhaps they will need to explain that one to the court.
It's all very interesting that they dragged this out another six years (at least) and made how much money? Would love to know how much the CEO has pocketed between 2015 and now off the notion that DCVax-L might work. I can tell you it's a lot of money. And I can tell you that the whole time she's been making that money she's known a lot of things about this trial that she hasn't shared with shareholders. Despicable, unethical, and disgraceful are the first words that come to mind.
This post wins the 2021 Purple Prose Award for fantasy writing.
Why are they refusing to release the data?
I'm not trying to scare you away from NWBO. You can do what you want, and I wish you the best. I sincerely hope you turn out to be right and I am wrong. But I would just caution you against the utter BS you read because almost none of it is true. This company lies to its shareholders, and that is not good. It's a really bad indicator. There are so many ominous signs here it's just not worth going over them again, so I would say just be very cautious and do not trust the people running this company.
My only objective is accountability. Only shareholders can hold these people accountable because the board of directors is clearly not interested in doing their job. At some point, I'm afraid, it's going to take a collective shareholder action to force an end to this perpetual game that NWBO is playing. When will that happen?
You have every reason to be spooked. The people running nwbo are a joke. They are incompetent and they are liars. People here think the data is a slam dunk to show efficacy, but for some reason the company keeps trying to move the goalposts closer by changing the endpoints on the trial and using historical comps instead of the trial’s own comparative data. Now why would they do that? You certainly wouldn’t make those moves if you think the data is a slam dunk. That’s just common sense.
But the most important reason you should be spooked is that the company is refusing to release the data, even after promising in writing they planned to release it 10 months ago. The fact that we are still sitting here with no explanation and no expectation for TLD anytime soon is a very bad sign. People want to overcomplicate things, but the simple truth is that if the data were good they wouldn’t be sitting on it. Everybody knows that. People are dying from GBM and yet people want you to believe nwbo hasn’t released game-changing data because they are waiting on a publication. Give me a break. It’s ridiculous, and it’s a lie.
And to those who still wonder why I am here, remember that in order to hold these people accountable, one must be a shareholder. That’s the way it works.
NWBO is an outright SCAM, and those of you who have big money tied up in this POS stock should seriously rethink what you are doing.
How long are you going to let them jerk you around like this?
How long will you let them lie to you over and over again?
What kind of company lies to its shareholders anyway? Seriously. It's amazing that we have to ask that question. What kind of company intentionally tells falsehoods to its shareholders? Because that's what this company does. So many try to excuse away their falsehoods and lies, but that is what they are. There can be only two explanations: 1) abject incompetence, or 2) they are liars. I think it's a combination.
What kind of company is so absurdly incompetent that it has its IR person put out multiple press releases announcing data lock and the release of TLD and then it fails to follow through on every one of those promises? I mean, my god, what they have done is so incredibly amateurish and unprofessional, and it's not the first time they have done something similar. Whether it's failing to submit their OTC registration on time because everybody had the flu, or the many times over the years they've made it seem like TLD was coming at any moment and then just pretended like, "Nah, we never said that", the incompetence and deceit is staggering. Now the IR person goes silent and says they're in a quiet period so he can't comment and can't provide any explanation for why they lied to shareholders. The only thing he can say is that now they don't expect TLD for many more months (years?)? Who does that? It's just beyond exasperating that anyone still has any hope for these stupid, incompetent people who lie with impunity and/or are so incompetent that they can't execute the most vital and critical aspects of corporate communications. Does anyone think this is a good sign for what's to come? OMG, this is such a joke!
No one is going to partner with these fools. The one credible person associated with this operation, Dr. LL, gave up on them some time ago because she knows what a joke they are. How long will you give them the benefit of the doubt when they give you no reason to continue believing anything they say? Are some shareholders just gluttons for punishment who like to be abused? Sure seems that way. What a sad, sad place to be.
WTF is going on here? Why aren't shareholders revolting against this absolutely insane treatment? Does no one care? Wake up!
That's why you can't trust anything you read here. Also, Dave Innes is absolutely useless. It's almost hard to imagine this, but of the three IR people NWBO has employed during my time as a shareholder, he is the worst. By putting out multiple false dates for data lock and TLD in 2020, the communications shitshow he orchestrated was one of the most embarrassing examples of corporate communications I have ever seen. Not to mention all the false hypes he put out ("Come to the shareholder meeting. It's going to be interesting!") completely coincidentally right as they were handing out a bunch of warrants, and the underhanded way he implies material information in personal phone calls with individual shareholders - information he knows will be relayed here. It really pushes the boundaries of ethical propriety.
I think the only effective thing he's done is hire Joan Lappin to pitch his propaganda. She was an odd choice, but the strategy actually showed some positive results - for a while anyway. But since the company has never followed through on anything she has written, her credibility is now shot. No one believes anything she writes about NWBO anymore, so she can thank the company for making her look like a fool. Hope she was paid enough to make it worth it.
I am still just flabbergasted at the idea a company would publicly put out the kinds of expectations NWBO did in 2020 and fail to deliver on all of them, and then leave shareholders twiddling their thumbs 10 months later with no explanation. It's just utterly mind-boggling. At the 2019 ASM, one of the board members talked about how excited he was to have a new IR person because in a short matter of time the company would be doing a much better job of telling its story to the world. But the truth is this company's communications program is worse than it's ever been, and that's really saying something. That seems to be management's goal, though, so I guess DI should be proud.
That's a phenomenal film. One of my favorites.
BTW, you still haven't showed me a single instance of LL mentioning NWBO or LP from anytime in the last couple of years. That's because she hasn't. The book excerpt you posted does not mention NWBO at all. Isn't that odd? Now ask yourself why that is.
Dr. Linda Liau's PowerPoint presentations don't have anything to do with Northwest Biotherapeutics's Phase 3 DCVax-L Trial for Treatment of Glioblastoma.
She's using DCVax-L in her own trial (though she doesn't call it by that name in the official trial description even as she did use other brand names), but otherwise her PowerPoint slides don't have anything to do with what NWBO is doing with DCVax-L. There is zero relation. Do you not understand that?
NWBO has taken 16 years to prove nothing, and Dr. Liau now knows that NWBO's godforsaken Phase 3 trial was a complete waste of time because it was mismanaged and is now unable to make a valid case for the efficacy of her invention. She also knows that the people in charge of NWBO have been milking it for six years, paying themselves handsome salaries and working on building out a manufacturing operation that in the end won't have anything to do with NWBO or DCVax-L. That's why you haven't seen Dr. Liau mention NWBO or its CEO at all in the last almost two years or so. There was a time when the two Lindas were chummy, and they talked about each other all the time. But not anymore. The long article about LL that someone posted yesterday doesn't mention NWBO even once. That's pretty weird, don't you think, to write such an extensive piece on the good doctor and not even mention the supposed flagship trial for her invention? I'm sure that was just an oversight by the reporter.
The thing that really digs is the suppressed knowledge that all of this is true. It causes a great flustering and results in single-word replies like "Nonsense", which is kind of sad when you think about it.
There's a bad smell in the air right now about NWBO. The CVM news yesterday didn't help, but I think everybody has a grim sense of what's coming.
There are many who claimed that the long delay between data lock and TLD is proof that the DCVax-L trial is a success. But CVM just showed that speculation to be nothing but lies. Add it to the list of falsehoods that are repeated incessantly.
Looking at the CVM halt this morning, I'm still wondering why Schwab put a Regulatory Circuit Breaker on NWBO last week. I can promise you it's not because they think the stock is going to skyrocket. Now why would Schwab have done that? Or, did someone ask them to do that?
So is anyone going to explain the "Regulatory Circuit Breaker" notation that is now next to the NWBO symbol, at least on Schwab? Is this really new? If so, are we just going to ignore it and vanish all references to it? What does it mean? Why is it there now but not before? Seems like this could possibly be a very concerning development for all invested, but, as usual, it just gets swept under the rug. I will accept any reasonable explanation because I have never seen it before, but if what I am reading is correct, this is yet another very troubling sign.