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Replies to #10850 on Biotech Values
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10nisman

05/20/05 3:44 PM

#11426 RE: DewDiligence #10850

Dew,

In regards to GTCB, what is your latest probability of EMEA approval? Just trying to determine if I should be buying more at the current levels.

Thanks,
10nis
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io_io

06/30/05 5:39 PM

#12723 RE: DewDiligence #10850

Pharming:

Is this the rumored partnership ?




Leiden, The Netherlands, June 30, 2005.

Pharming Group N.V. (“Pharming” or “the Company”) (Euronext: PHARM) (PHAR.AS) announced today a partnership with AgResearch Limited (“AgResearch”) on the production of recombinant human lactoferrin (“rhLF”). In addition, Pharming has granted AgResearch a research license to its proprietary protein production technology.

Pharming and AgResearch have partnered on the manufacturing of recombinant human lactoferrin. AgResearch will be responsible for the production of rhLF and will provide access to its purification as well as research capabilities for product development. AgResearch shall bear costs associated with the initial production of rhLF and support the commercialization of rhLF through its extensive network in the South Pacific and Asia.

“The alliance with AgResearch is in line with Pharming’s strategy to form partnerships for the manufacturing and commercialization of its products,” said Dr. Frank Pieper, CSO of Pharming. “In addition, Pharming is pleased to provide AgResearch a license to its protein production technology and expects further licensing of the technology for various applications.”

Pharming has granted AgResearch a research license to its proprietary technology for the production of recombinant proteins. In return, Pharming will have the first right to review new products arising out of AgResearch’s protein discovery and R&D projects. The commercial rights of Pharming will cover recombinant bovine and human proteins produced using its proprietary technology.

Pharming is currently preparing a filing on rhLF for Generally Recognized as Safe (“GRAS”) registration with the US Food and Drug Administration (“FDA”). Results from toxicology studies demonstrated that rhLF can be consumed orally at high amounts with no adverse effect.

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DewDiligence

07/16/05 5:21 PM

#13318 RE: DewDiligence #10850

GTCB ReadMeFirst

[Items in bold-face type are those
considered to be of greater interest.]



Annual shareholders meeting (5/25/05)
#msg-6478142 5/25/05 Webcast, slides, Q&A notations


Valuation and finances
#msg-6745233 Musings on valuation
#msg-6177856 Notes on the 1Q05 CC
#msg-6183031 Cash position
1Q05 CC link: http://tinyurl.com/dbdrg
#msg-6174965 1Q05 press release
2004 Annual Report: http://www.gtc-bio.com/investorinfo/annualreport2004.pdf (allow time for loading)


ATryn development program in Europe
#msg-6231451 EMEA to conduct inspection (stock was at 85 cents)
#msg-6151290 Now GTCB’s game to lose
#msg-6762063 Market opportunity
#msg-6887393 7/6/05 Press release (GTCB submits answers)


ATryn development program in U.S.
#msg-6632863 U.S. ATryn timeline
#msg-6542448 Market opportunity
#msg-6543884 Non-availability of competing antithrombin
#msg-5601222 U.S. trial uses pooled data
#msg-5607789 Efficacy endpoint is *clinical* DVT
#msg-5609005 Design of control arm
#msg-6632420 Patient eligibility and exclusions


General info on ATryn and plasma-based antithrombin
#msg-4372780 Risks of plasma-derived proteins
#msg-4988136 ATryn vs plasma antithrombin
#msg-6795394 Role of ATryn vis-à-vis oral anticoagulants


Musings on business model and protein production
#msg-4364077 (Urche)
#msg-4359874 (Dew)
#msg-6242807 (Poorgradstudent)
#msg-2820748 (Biowatch)
#msg-6240481 Other companies to watch


General IP and non-ATryn development programs
#msg-5054169 Human serum albumin
#msg-3007897 Preclinical cancer program
#msg-4316445 Bioterror contract with U.S. army
#msg-6532405 Remicade (JNJ)
#msg-6488263 Alpha-1 Antitrypsin market size
#msg-5027284 Nuclear-transfer IP (Geron)
#msg-4107224 IP license to Nexia


Miscellaneous topics
#msg-4787482 New high-pedigreed GTC directors
#msg-6493919 Sell-side analyst reports (5/05)


Articles about GTCB and transgenics
#msg-6806806 Wall St Transcript interview with Tom Newberry (6/05)
#msg-6775592 Newsweek special issue on healthcare (6/05)
#msg-6276428 Worcester, MA Telegram & Gazette (5/05)
#msg-4057315 The Economist (9/04)
#msg-3990950 Chemical Market Reporter (9/04)
#msg-3631094 Boston Herald on bioterror (7/04)