Replies to post #48472 on NanoViricides Inc (NNVC)

[NNVClover]

PEG is one of the safest things known to man.
PEG-irinotecan would be one example of a not so safe PEG drug. You can add PEG to anything. PEG-interferon is the most commonly used drug. It is quite toxic. PEG does reduce peak blood levels of drug which lowers toxicity. It's a great invention for biotech based drugs and increasingly Nektar and Enzon (the PEG companies) have been able to attach them to small molecules. It's just a delivery tool. PEG by itself does nothing--it's inert pharmacologically.

[mdphd1]

Doc: No one doubts that PEG is safe, the potential problem is from the peptide ligand on the micelles. You mentioned 10x16 micelles/cc, each of which will have peptide ligands. That's a lot of protein, against which an immune response can be generated. A case in point is that a while ago, adenoviral vectors were used for gene therapy at a titer of millions of particles/mL, the main problem turned out to be the host immune response. For this reason, I dont buy the idea that the CIDES are completely non-toxic, especially if repeat administration will be required, eg for HIV.