The ligand peptides are the same as those contained on the host cell. The only interaction is between the invasive viral particale and the targeting micelle.
The case you refer to attempted to use the same mechanism as the invasive virus. Of course it elicited an immune response. There have been chimeras produced that exploit the same mechanisms for RNA therapy. THey also run into problems.
As I said, it is as nontoxic as water and will be proven nontoxic.
Immunogenicity always occurs in foreign administration of native proteins (eg EPO HGH etc). Don't forget there is sparse data on degradation of 'nanoviricides'. Proteases/polymerases are ubiquitous and destroy polymer molecules like these quickly.
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