Replies to post #48498 on NanoViricides Inc. (NNVC)

[BonelessCat]

PEG-interferon makes my point. Interferon is the toxic part; the PEG makes it tolerable and usable.

>>"It's just a delivery tool. PEG by itself does nothing--it's inert pharmacologically."

Exactly. Even your best example only demonstrates that PEG renders toxic drugs usable. The PEG platform is the part that is safe as mother's milk.

[Ubertino]

PEG is one of the safest things known to man.
PEG-irinotecan would be one example of a not so safe PEG drug. You can add PEG to anything. PEG-interferon is the most commonly used drug. It is quite toxic. PEG does reduce peak blood levels of drug which lowers toxicity. It's a great invention for biotech based drugs and increasingly Nektar and Enzon (the PEG companies) have been able to attach them to small molecules. It's just a delivery tool. PEG by itself does nothing--it's inert pharmacologically.

And that is one reason for FDA tox testing!