Doc: No one doubts that PEG is safe, the potential problem is from the peptide ligand on the micelles. You mentioned 10x16 micelles/cc, each of which will have peptide ligands. That's a lot of protein, against which an immune response can be generated. A case in point is that a while ago, adenoviral vectors were used for gene therapy at a titer of millions of particles/mL, the main problem turned out to be the host immune response. For this reason, I dont buy the idea that the CIDES are completely non-toxic, especially if repeat administration will be required, eg for HIV.
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