Replies to post #439347 on NorthWest Biotherapeutics Inc (NWBO)

[hoffmann6383]

good post flipper

[eagle8]

Great post flipper.
Thanks for the total picture.

GLTU

[newman2021]

Amen Amen Amen!!!! Thanks flipper, you are the eyeopener for many here.

[Doc logic]

flipper44,

Yep to keep interference from the outside to a minimum they continued making slow, steady, silent progress or pretty much something like that ; ). Best wishes.

[BerkyBaller1947]

Thank you for your invaluable insights, now, and in the past. You strengthen the resolve of many and fortify our spirits as we look to a bright future in the battle against cancer.

[sukus]

Very informative Flipper. Thanks.

[CaptainObvious]

You get the Post-of-month parking spot.

This timeline makes it apparent that there has been an inexorable march forward

[highwayman4life]

[flipper44]

Pardon. “Grand round”, not “ground round.” Must have been a typo confounded further by auto spell check.

[hoffmann6383]

Thanks again Flipper. Question for you. Something I've never understood, but I'm probably missing something really simple.

I understand how the WHO redefinition of GBM to exclude proneural tumors helps NWBO's data as our vaccine shows as more effective in mesenchymal/classical tumors. (side question, is the WHO definition also accepted by the FDA?)

You didn't state this here, but I've seen it from other posters that the redefinition actually increases the potential market of dcvax-L.

My question is, wouldn't this redefinition and LL's comments lead you to believe the potential market is actually being cut in half?

TIA

[survivor1x]

Sticky this one!

For the Johny come lately's. Flipper laid out years of DD and history on this.

There is always risk in investing but this reminds me why I am invested.

[jimmy667]

Wow! Bravo Flipper! Excellent summation of the brilliant work of NWBO to get this important cancer treatment litterally to the very door step not only of approval but wide spread availability to patients and Doctors/Hospitals.

[The Danish Dude]

What a great resumé flipper! I lack emojis!!!!!! Yes sticky!!!

[Bob_LobLaw]

this post needs to be stickied. well done sir!

[sentiment_stocks]

Great job lining up a quick synopsis of where we are now, and key events that have led us to this point.

Interesting how, if you think about it, the stars have somewhat aligned for DCVax-L as time has passed, making, of course (IMO) an eventual approval and getting this to patients that much more likely.

[Chiugray]

Flipper, Thanks for compiling and sharing these 22 points. I can literally now see that all ducks are in a row, and perhaps a lot more!


I think the cloud of dust building up in the background are new investors. :-)

[MI Dendream]

Flipper…amazing puzzle piece fitting. You put that all together and what do you get… a plan that began with the ingredients pulled together 8 years ago, the preparation done 7 to 2 years ago, the baking over the past 2 years and the masterpiece revealed very very soon filling our cornucopias for generations.

This all reminds me of a leadership development game that was used to learn about the importance role players and specialists… the Viking Legacy.

You do a personality test,one that was not Jungean based. Then teams of about a dozen get divided, two with all similar types, but one yin and one yang. Then a third with Yin, Yang and a collection of the unique specialists. I am Pioneer and an Omega. I lead from the back of the room, not the front where Alphas play.

Anyway there are like 800 cards with like 200 of value. They contain facts, dates, pathways, etc. You need to identify where the viking hoard began, what route they took, what were the dates of the journey, and where did they settle. The third group ALWAYS crushes the first two, sometimes hours ahead, sometimes the first groups can’t even finish.

This board is the third group. The A-type team usually looses to the analytical types who take forever.

[foxhound02]

Question, how in the hell do you “buy” over a half decade of time to develop Dendritic Cell commercial manufacturing method before you take a trial to data lock?

Am I reading this right? Are you saying they stalled the trial for years waiting on manufacturing?

Are you serious?

[MI Dendream]

Remember this date? It looks a little different since Bigger and others dropped that Kaboom of a government investigation now, doesn’t it?

Imagine where Direct would have…BTW… when will they give us final or updated Direct phase I data?

19
OCT
2015
NW Bio Issues Statement on Highly Unusual Trading Activity
Reiterates Encouraging Clinical Data;
Sees Coordinated Shorting Campaign

BETHESDA, MD, October 19, 2015 – Northwest Biotherapeutics (NASDAQ: NWBO) (“NW Bio”), a U.S. biotechnology company developing DCVax® personalized immune therapies for solid tumor cancers, today issued the following statement addressing the recent highly unusual trading activity in the Company’s stock:

NW Bio is not aware of any fundamental reason for the substantial decline in the price of the Company’s stock on Friday, October 16. Indeed, NW Bio presented encouraging clinical data at scientific conferences in London and New York as recently as mid-September.

The Company’s clinical data update included promising ongoing interim survival data from both the Phase I trial of DCVax-Direct in 13 diverse cancers, and the Information Arm of 51 patients who were unable to enroll in the Phase III trial of DCVax-L for newly diagnosed Glioblastoma multiforme (GBM) brain cancer because of apparent early tumor recurrence.

In the DCVax-Direct trial for patients with multiple inoperable metastatic tumors who had failed standard treatments (including multiple different chemotherapy regimens), half of these patients are still alive with survival times now ranging up to 22 months, exceeding expected survival times.

In the DCVax-L Information Arm, for the 25 GBM patients with apparent early tumor recurrence at one of two time points, 40% of the patients have now reached or exceeded approximately 3 years’ survival. This substantially exceeds the expected survival time of about 15 months even for regular GBM patients without early tumor recurrence.

NW Bio noted that the Company’s shares have experienced highly unusual trading activity since the September release of positive data, including especially on Friday, October 16, when more than 2.9 million NW Bio shares were traded, representing five times its recent average daily trading volume. The Company believes this activity is part of an ongoing effort to drive its stock price lower through an orchestrated campaign, including questionable short selling activity. The Company is intensifying its investigation and gathering of evidence.

[MI Dendream]

Flipper, thank you! BTW… eye opening.

This was my favorite one because…I did not even know this much less put them all together. I must have skipped those days. If you have a link, please share.

12. Dr. Liau recently acknowledged (2022) cell immunotherapies have been challenging in the past to manufacture. A year prior, she stated we’ve got to find a way to get this treatment to patients.

You know, his name fits great into a cheer.

Shashi Murthy…dun, dun…dun dun dun…Sashi Murthy… dun, dun,…dun dun dun…Sashi Murthy

Why didn’t we have pep rallies for really smart people too?

[Mionaer1]

Brilliant once again.

[dmb2]

flipper44,

thx much for the capture, makes one desiring to purchase more shares

It is my opinion and hopes that NWBO used the time to complete their automated process qualification work, but that the wait for 5 year survival data was the driver of the timeline and not the mfg process. Maybe it was both who knows for sure. I think they could have moved ahead with 3 year data but the K-M chart would not have been as positive at the 5 yr time point if they went with 3 yr survival data. And, no doubt they have made much mfg process progress in the last 2 yrs.

GLTA

[Dr Bala]

Great post. The sequence of events speaks of good data reveal. Thanks, Flip.