I thought the generic was within a range of the brand for therapeutic equivalence and that range was within 80 to 120%. Maybe I read that wrong and someone can post the information. I can always tell when CVS changes generics brand for lisinopril and I feel different for a few days until I get use to the new medication even though the dose is the same.
Bio equivalency and therapeutic equivalency are different things.
Low therapeutic index drugs (synthroid) need the therapeutic equivalency for obvious reasons. Furthermore, the issue is dose titration. Even the branded drug will need dose titration. When switched to generic, it will also need some tweaking before it can work
Bio equivalency for high therapeutic window drugs will translate to clincial equivalency. The reason 80-125% works has to do with the fact that humans come in difference size shape and ethnicity. Drug response is a range and not a specific number. Even for a branded drug two individuals with same dose will have different AUC.
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