Replies to post #233333 on Anavex Life Sciences Corp (AVXL)

[rayovacAAA]

EXPECT THE TRIFECTA EXTREMELY VERY SOON!!!!!



GOOD LUCK AND GOD BLESS!!!!

[F1ash]

Professor Macfarlane has NOT violated any protocol for this trial. Professor Macfarlane has made logical inferences from observation and experience that subjects that are responding much better than normal over time and mention that they have minor dizziness at times are most probably taking the active drug in this case Anavex 2-73 than just taking a placebo. That is NOT a violation of the blinding protocol of the trial. That is a logical inference from an experienced health care provider.

The “issue”, if indeed it does prove to become an “issue”, is not that Dr. M made the logical inference. Imho, It’s that he disclosed that inference in the very same article that is also requesting interested parties to enroll in the trial at issue.



“People living with very early and early stages of Alzheimer’s disease in Sydney and Melbourne and are up to the age of 85 interested in participating in the study can email [e-mail] ”



“Participants getting side effects, such as dizziness, suggest improvements from the drug, he said.”

https://www.australianageingagenda.com.au/2020/01/31/early-findings-of-alzheimers-drug-trial-show-promise/?unapproved=10398&moderation-hash=3e16534a9c96875ff72e335e7d85f72d#comment-10398

Has he not set the expectation that trial participants can have a strong indication that they are receiving the Active drug if they develop dizziness? Has he influenced the occurrence of dizziness from placebo patients who might not otherwise have reported that symptom?

Looks like a possible unforced error imho.

[frrol]

No. There are no thought police making sure no one involved in a trial is making inferences, logical or nonsense, about drug effects. He can do all the inferences (and his have logical basis) he wants, for hours on end. So can anyone.

The issue we're talking about is publicly stating them as a trial agent. There are even restrictions on privately stating them among each other. Those restrictions are not absolute, but they are extensive and based on important reasons having to do with maintaining blinds and minimizing bias.