Replies to post #233340 on Anavex Life Sciences Corp (AVXL)

[anders2211]

Has he not set the expectation that trial participants can have a strong indication that they are receiving the Active drug if they develop dizziness?

Im really at a loss here. Its already known for years that a symptom of improvement is dizzyness, the whole max dozing stated by Missling etc.
Now patients can read and google, therefore figuring out for themselves if they are on the drug or on placebo if dizzy or not. What rule did Macfarlane violate again by repeating this public known secret...?

[512]

Are you saying people that agree to be in the trial are not made aware of the possible side effects of the drug?

[georgejjl]

Has he not set the expectation that trial participants can have a strong indication that they are receiving the Active drug if they develop dizziness? Has he influenced the occurrence of dizziness from placebo patients who might not otherwise have reported that symptom?

He has NOT set the expectation that trial participants.

The information regarding dizziness has been public information for the Anavex trials and other Alzheimer's trials for years. This is NOT new information with this article.

Tolerability: Maximum tolerated dose (MTD) of ANAVEX 2-73 was defined as 55mg. Observed adverse events at doses above the MTD included dizziness and headache, which were moderate in severity and reversible. These side effects are often seen with drugs that target CNS conditions, including Alzheimer’s disease.

https://www.anavex.com/anavex-announces-positive-phase-1-data-for-anavex-2-73-lead-candidate-for-the-treatment-of-alzheimers/

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Aricept (donepezil hydrochloride) is a cholinesterase inhibitor that reduces or prevents acetylcholine breakdown in brain tissue. Aricept is used to treat mild to moderate dementia like that found in patients with Alzheimer's disease. Aricept is not a cure; it reduces symptoms. Aricept is available as a generic. Common side effects of Aricept include

feeling unwell (malaise),
appetite loss,
weight loss,
sleep problems (insomnia),
muscle cramps,
tiredness,
drowsiness,
dizziness,
weakness,
shakiness (tremor),
itchy skin,
nausea,
vomiting, or
diarrhea.

Good luck and GOD bless,

[frrol]

Yes. Happens. Rarely, thankfully.

[Gernee20]

The patients are told about possible side effects as these are safety trials as well