Replies to post #203561 on Anavex Life Sciences Corp (AVXL)

[georgejjl]

A Walnut-Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial

The abundance of Ruminococcaceae and Bifidobacteria increased significantly (p < 0.02) while Clostridium sp. cluster XIVa species (Blautia; Anaerostipes) decreased significantly (p < 0.05) during walnut consumption. The effect of walnut consumption on the microbiome only marginally depended on whether subjects replaced fat, carbohydrates or both while on walnuts. Daily intake of 43 g walnuts over eight weeks significantly affects the gut microbiome by enhancing probiotic- and butyric acid-producing species in healthy individuals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852820/

[Investor2014]

I can see the wording could at a stretch be misleading, perhaps sloppily or deliberately so.

Slide 14. Replace "ANAVEX 2-73 Treated" with "Alzheimer's" - Patients have higher Abundance of Bacteroidetes and Firmicutes Phyla in Gut Microbiota.

The implication being that a messed up gut, perhaps through decades of poor diet and lifestyle choices, characterises people who ends up with AD.

Slide 15, say that if a patient have those to bacteria families in higher abundance they respond better to A2-73. It does not say A2-73 caused that higher abundance.

Slide 16, I find that statement inscrutable or just highly speculative. Like what came first the chicken or the egg.