Replies to post #203564 on Anavex Life Sciences Corp (AVXL)

[XenaLives]

I don't believe that is a valid inference or conclusion -

Slide 14. Replace "ANAVEX 2-73 Treated" with "Alzheimer's" -

Perhaps they are testing the P2b folks more frequently in order to get more info. I think "chicken or egg" is the best analysis at this time.

[TempePhil]

Regarding the gut bio vs cns cause/effect question (chicken/egg), Investor and tradeherpete have been discussing.

I read the publication several times looking for which was the cause and which was the effect. This would be very important information! I agree the wording is vague, and certainly not clear to me which is the cause.

I think the writers intentionally did not specify this cause/effect because they did not know. Certainly in a science publication, like this, they would love to break that kind of news. But when one does not know the cause, just publish the data. That is what I think we have here.

To their credit they are studying some of the first data available and they do not have all answers and mechanisms understood yet.

[tradeherpete]

The analysis says that when patient have a higher abundance of those two families of bacteria they respond better to A2-73.

It does not say that A2-73 raises the abundance of those bacteria families.

There is a difference!

Well, the conclusion does and I'll give you, it's a stretch. But so was that post. The tone was less than boilerplate scientific.

So yes, good catch.

The point of my post is also unsubstantiated by the data which is:
Our microbiota is an intimate part of who we are, has a lot to do with who we are and we are just becoming acquainted with it. And suggesting we begin acting more graciously with our new friends. Who might as well be alien beings.