Replies to post #11044 on NorthWest Biotherapeutics Inc (NWBO)

[terry hallinan]

Doktor,

Just scanning some of the abstracts on temozolomide toxicity, I came across this stray:

Case presentation

We report the case of severe liver toxicity with jaundice during radiochemotherapy with temozolomide likely due to interaction with a popular Chinese herbal formula after surgery for glioblastoma. After cessation of the herbal formula as well as the chemotherapy liver enzymes slowly normalized. Due to tumor progression the patient was retreated with temozolomide for 5 cycles without toxicity. Because of further progression combination treatment of bevacizumab and irinotecan was started and again no liver toxicity was observed.

http://www.biomedcentral.com/1472-6882/14/115

The thought occurs that temozolomide is a popular choice for treating brain cancer with radiotherapy, assuming it is, because of its low toxity but that something else may interfere as in the above case.

Isn't it awful that people have to be subjects of medical experiments? Some day that may not be necessary.

Best, Terry